(1) The data were grouped to determine differences between the experimental and the newly revised formats of the GRE-A measure, in addition to any differences among programs.
(2) However, a purified recombinant fragment of the GR which contained essentially only its DNA binding domain was unable to bind at the GME although it interacted strongly with a consensus GRE sequence.
(3) Although GRE images rapidly demonstrated flow in vascular intracranial lesions as high intensity, the vascular nature of these lesions was also clearly evident on SE images in most cases.
(4) We have used cloned rat glucocorticoid-receptor coding sequences to produce and characterize a novel class of receptor mutants that elicit GRE enhancer function in transfected cells even in the absence of hormone.
(5) The MR appearance of thrombosis of the portal vein and its branches using gradient echo (GRE) sequences is described.
(6) Assuming that function as a GRE reflects binding of glucocorticoid receptor, our activity data are consistent with the recognition of the GRE as two hexamer half-sites, each half-site recognized by a single subunit of a receptor dimer, probably in a cooperative fashion.
(7) The sequence recognition by the glucocorticoid receptor at the different defined glucocorticoid regulatory elements (GRE) is discussed and a consensus sequence formulated.
(8) We found that the promoter is extremely G + C rich (72% GC content) and contains a "TAATA" and a "CAT" box, eight "GGGCGG", three "CCGCCC" and two "CACCC" motifs and a motif similar to the glucocorticoid responsive element (GRE) which included two interchanged nucleotides "TCTTGT".
(9) Gel retardation analysis demonstrates that bacterially expressed c-Jun disrupts GR-GRE complexes.
(10) These results demonstrate the importance of GRE consensus sequences in glucocorticoid receptor interactions with DNA, and further identify a cause for high background binding observed when pBR322 DNA is used as a negative control in studies of glucocorticoid receptor-DNA interactions.
(11) Given the "time of flight" effect of GRE sequences, a scan plane perpendicular to the direction of flow was used to obtain maximal signal enhancement of flowing blood.
(12) All pRagCAT constructs in which the 5'-region contained at least one of the two GRE consensus sequences were stimulated by dexamethasone.
(13) Oversaturation (2.0 mumol Fe for SE sequences, greater than or equal to 1.0 mumol Fe for GRE sequences) led to image distortion and did not allow assessment of lymph node morphology.
(14) To accommodate the observed biphasic dose-response curve for highly specific glucocorticoids, and the shift-to-the-left for both classes of effector, we have proposed a model of a single "turn-on" nuclear acceptor site for glucocorticoid receptors (glucocorticoid regulatory element: GRE) and multiple, pre-emptive "turn-off" GREs, occupancy of any one of which will abrogate transcription; for progestins, we propose that all the GRE are alternate "turn-off" sites.
(15) A moderately repetitive DNA sequence, containing a TATA box, a GRE consensus, a Z-DNA forming sequence and two imperfect direct repeats at the extremities, is present a few nucleotides 5' of the human PAI-1 gene transcription start site, raising the possibility that this gene could have been activated by DNA insertion during evolution.
(16) In vitro transcription experiments using a Xenopus laevis cell-free extract have demonstrated that a DNA fragment containing a glucocorticoid response element (GRE) significantly enhances the expression of a methionine tRNA gene.
(17) R1881-activated transcription of a GRE-tk-CAT reporter gene construct was strongly diminished by both mutant receptors and was only partially restored using a 100-fold higher concentration of ligand compared with wild-type receptor.
(18) New cine GRE imaging techniques provide a noninvasive means for quantification of valvular as well as ventricular function.
(19) To investigate the detection of vascular extension of tumor with the GRE technique, findings in the preoperative GRE MR images of 26 patients with renal adenocarcinoma were compared with findings at surgery and pathologic examination.
(20) Our results demonstrate that in-plane GRE imaging and MR angiography can potentially be used as noninvasive methods for evaluating vascular patency in the presence of MR-compatible endovascular devices.
Ure
Definition:
(n.) The urus.
(n.) Use; practice; exercise.
(v. t.) To use; to exercise; to inure; to accustom by practice.
Example Sentences:
(1) In addition, the URE appears to play a role in promoting the replication of polyoma DNA as determined through two different experimental approaches.
(2) Each open reading frame was preceded by a ribosome-binding site, with the exception of ureE.
(3) The results of short-term tests (uring adriamycin, daunorubicin, and dactinomycin) in roughly 100 human tumors were compared with data in the literature on therapy with the same cytostatic agents.
(4) However, in females exposed to female uring during the first 7 days of VC this effect was absent.
(5) It starts to feel like it’s a process where if you give money you solve the problem, and really sometimes giving money creates another problem.” When he was told there was just one African-born performer on the track, he said: “That’s great, just a few more would be nice and also maybe go there – all those people who are making that.” Ultravox’s Midge Ure said the song was by no means a masterpiece, but is more about getting people as engaged with the fight against Ebola as they were in 1984, when a total of £8m was raised.
(6) Diagnosis depends on detection of persistent bacteriuria by careful screening and culture of properly collected uring specimens.
(7) The rIL-2 infusion caused a reversible fall in ures and a non-reversible rise in creatinine.
(8) The experimental evidence suggests that either the repression associated with the URE sequence is mediated by a direct, one-to-one interaction between the proteins recognizing the URE and GCRE, or alternatively, that there is a direct interaction between the activator and repressor for a general transcription factor.
(9) Furthermore, repression is seen when the URE is separated from the UAS by up to 214 bp.
(10) This suggests that either a different accessory element and cognate protein interacts with the horse URE to provide placenta-specific expression or that a completely different set of regulatory elements is required for placenta-specific expression in horses.
(11) A polyacrylamide gel electrophoresis, without sodium dodecyl sulfate-uree, of the total serum allowed after incubation with the N-acetyl-beta-D-glucosaminide (6-bromo-2-hydroxy-3-naphthoyl-O-anisidine) coupled with the diazonium salt of O-amino-azotoluene to localise two zones of enzymatic activity.
(12) The predicted UreE and UreG polypeptides exhibit some degree of similarity with the respective polypeptides encoded by the accessory genes of the Klebsiella aerogenes urease operon (33 and 92% similarity, respectively, taking into account conservative amino acid changes), whereas this homology was restricted to a domain of the UreF polypeptide (44% similarity for the last 73 amino acids of the K. aerogenes UreF polypeptide).
(13) We have cloned ivoB which codes for a conidiophore-specific phenol oxidase (AHTase) via the adjacent selectable ureD gene.
(14) Nuclear proteins extracted from JEG-3 choriocarcinoma cells bind specifically to oligonucleotides corresponding to both the URE and CRE domains as well as to a downstream domain (-99 to -72) that contains consensus CCAAT motifs on both the sense and antisense strands.
(15) Thus, one or more of the ureE, ureF, or ureG gene products are involved in nickel incorporation into urease.
(16) Adult DDE and URE were induced to express seminal cytodifferentiation and produced the complete spectrum of major seminal vesicle secretory (SVS) proteins.
(17) Perinatal exposure of mice to URE has been found to result in increased tumor induction compared to exposure of adult animals.
(18) In transient expression assays, the upstream and downstream domains of the URE were shown to independently enhance CRE-mediated transcription of the alpha gene.
(19) Binding to this multisite DNA fragment is readily disrupted using the URE sequence, but not the CRE sequence as a competitor, suggesting that the URE binding factor may stabilize DNA-protein interactions in these adjacent complexes.
(20) This new regulatory element is highly conserved across species and contains a palindromic binding site for a 50-kDa nuclear factor(s) which is distinct from the factors that bind the URE, CRE, and CCAAT box of the alpha subunit gene.