(Compar.) Of forbidding or fear-inspiring aspect; fierce; stern; surly; cruel; frightful; horrible.
Example Sentences:
(1) This is the grim Fury on a rainy winter morning in Cannes.
(2) The level of prescribing of opioid painkillers – Percocet in Geni’s case – has soared, and with it the incidence of addiction, and addiction’s grim best friend: fatal overdoses.
(3) Patients with anti-NC1 antibodies were characterised by linear immune deposits along the glomerular basement membrane and the clinical outcome was invariably grim.
(4) The Mail branded the deal "a grim day for all who value freedom" and, like the Times, accused David Cameron of crossing the Rubicon and threatening press freedom for the first time since newspapers were licensed in the 17th century.
(5) ARD TV showing grim-faced FDP cadres: could this be the first time they fall out of national parliament in 60 years?
(6) It has said a better productivity performance and rising North Sea oil revenues will make the budgetary position less grim.
(7) Shields accepted that the Irish appeared more inclined to send up their grim fiscal situation than go out and riot.
(8) Inside the Islamic State ‘capital’: no end in sight to its grim rule Read more The Kurdish People’s Protection Units (YPG) militia and an alliance of rebels known as the “Euphrates Volcano” – backed US-led coalition air strikes – have seized swaths of territory from Isis, including the strategic border town of Tal Abyad .
(9) Yet, if that flurry of form pepped optimism, the injuries and displays in recent friendlies have provided a grim reality check.
(10) The dark, luxury air in the silent bedrooms of empty riverside apartments, their identical curving blocks clustered in threes and fours, grim and silent as gill slits, will be theirs.
(11) Chinese media and bloggers published images of three young children in blue school uniforms lying dead on the pavement – a grim echo of the high casualty rate at poorly constructed schools in Sichuan in 2008, when a bigger quake killed 87,000 people.
(12) The BCC survey represents a turnround from the end of last year, when it was predicting stagflation – a grim combination of zero growth and inflation.
(13) The human rights organisation, which has produced a series of in-depth reports detailing the grim working conditions of many of the 1.5 million migrant labourers engaged in a huge construction boom, said “little has changed in law, policy and practice” since the government promised limited reforms 12 months ago.
(14) Carcinoma of unknown histogenesis or primary site is an increasingly recognized syndrome regarded by most physicians as having a grim prognosis.
(15) "There are times when a swingeing sentence can act as a deterrent", as the judge at the trial was grimly to pronounce.
(16) The footage beamed back from the liberated districts of Ramadi is grim: a ghost town littered with debris and smashed concrete, destroyed storefronts, plumes of smoke, the sound of gunfire piercing the air as Iraqi soldiers speak on camera.
(17) It was my shortcomings as coach that caused this result,” said a grim-faced South Korea manager, Hong Myung-bo, who spent most of the post-match press-conference scratching his nose in apparent distress and deflecting comments about whether he would stay on as manager until next year’s Asian Cup.
(18) After grim news on the recession, at least one thing should become clearer: going back to where we were is no longer an option.
(19) While deplorable and to a degree self-defeating, this insouciant defiance also makes a grim kind of sense, both historically and reinforced by recent events.
(20) The entity carries a grim visual prognosis, as all ten eyes initially had no perception of light; improvement to light perception occurred in one instance.
Severe
Definition:
(superl.) Serious in feeeling or manner; sedate; grave; austere; not light, lively, or cheerful.
(superl.) Very strict in judgment, discipline, or government; harsh; not mild or indulgent; rigorous; as, severe criticism; severe punishment.
(superl.) Rigidly methodical, or adherent to rule or principle; exactly conformed to a standard; not allowing or employing unneccessary ornament, amplification, etc.; strict; -- said of style, argument, etc.
(superl.) Sharp; afflictive; distressing; violent; extreme; as, severe pain, anguish, fortune; severe cold.
(superl.) Difficult to be endured; exact; critical; rigorous; as, a severe test.
Example Sentences:
(1) We used the polymerase chain reaction (PCR) to amplify the breakpoint area of alpha-thalassemia-1 of Southeast Asia type and several parts of the alpha-globin gene cluster to make a differential diagnosis between alpha-thalassemia-1 and Hb Bart's hydrops fetalis.
(2) The newborn with critical AS typically presents with severe cardiac failure and the infant with moderate failure, whereas children may be asymptomatic.
(3) The low affinity of several N1-alkylpyrroleethylamines suggests that the benzene portion of the alpha-methyltryptamines is necessary for significant affinity.
(4) The main clinical features pertaining to the concept of the "psycho-organic syndrome" (POS) were investigated in a sample of children who suffered from severe craniocerebral trauma.
(5) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(6) Collins said she asked Sullivan several questions, including who the women were.
(7) Single-case experimental designs are presented and discussed from several points of view: Historical antecedents, assessment of the dependent variable, internal and external validity and pre-experimental vs experimental single-case designs.
(8) During and after the infusion of 5HTP, none of the patients showed an increase in anxiety or depressive symptoms, despite the presence of severe side effects.
(9) Histological studies showed that the resulting pancreatitis was usually mild to moderate, being severe only in association with sepsis.
(10) An “out” vote would severely disrupt our lives, in an economic sense and a private sense.
(11) No consistent relationship could be found between the time interval from SAH to operation and the severity of vasospasm.
(12) Also we found that the lipid deposition in the glomeruli of patients with Alagille syndrome is related to an abnormal lipid metabolism, which is the consequence of severe cholestasis.
(13) Sixteen patients in whom schizophrenia was initially diagnosed and who were treated with fluphenazine enanthate or decanoate developed severe depression for a short period after the injection.
(14) Concentrations of several gastrointestinal hormonal peptides were measured in lymph from the cisterna chyli and in arterial plasma; in healthy, conscious pigs during ingestion of a meal.
(15) In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
(16) Based on several previous studies, which demonstrated that sorbitol accumulation in human red blood cells (RBCs) was a function of ambient glucose concentrations, either in vitro or in vivo, our investigations were conducted to determine if RBC sorbitol accumulation would correlate with sorbitol accumulation in lens and nerve tissue of diabetic rats; the effect of sorbinil in reducing sorbitol levels in lens and nerve tissue of diabetic rats would be reflected by changes in RBC sorbitol; and sorbinil would reduce RBC sorbitol in diabetic man.
(17) The severity and site of hypertrophy is important in determining the clinical picture and the natural history of hypertrophic cardiomyopathy (HCM).
(18) After a discussion of the therapeutic relationship, several coping strategies which have been used successfully by many women are described and therapeutic applications are offered.
(19) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(20) Moreover, in DCVC-treated cells the mitochondria could not be stained with rhodamine-123, indicating severe mitochondrial damage and loss of membrane potential.