(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Grove
Definition:
(v.) A smaller group of trees than a forest, and without underwood, planted, or growing naturally as if arranged by art; a wood of small extent.
Example Sentences:
(1) Biological monitoring was performed for one year at the site of an orange grove on the left bank of the river.
(2) Where to stay: Beachside bungalows at Coco Grove Beach Resort cost £19 per person.
(3) In Gove's groves of academe, high achievers will be more clearly set apart, laurels for the winners in his regime of fact and rote, 1950s grammar schools reprised, rewarding those who already thrive under any system.
(4) In the (dpTpA)2:NQO and (dpApT)2NQO complexes, the NO2 seems to project into the minor grove and the NQO benzenoid ring is over the purine imidazole ring.
(5) The applicability to these data of the Groves and Thompson (1970) Dual-Process Model of Habituation is discussed.
(6) In the palm grove, transmission was ensured by 2 effective vectors during the rainy season (October to May).
(7) Schad was sentenced to death for killing Lorimer "Leroy" Grove, whose body was found 9 August 1978, in underbrush off the shoulder of US 89 south of Prescott.
(8) Perched in a grove of poplars and with prayer flags stretching away on all sides, Muktinath is Nepal's second-most sacred site for Hindus after Pashupatinath , which in comparison lies rather forlornly at the end of Kathmandu's international airport runway.
(9) The spark for the longest-running protest in modern Tunisian history was lit on 17 December in the town of Sidi Bouzid, in the rural interior of Tunisia, a region of olive groves and agriculture which is racked by vast unemployment, repression and poverty a world away from the riches of the Tunisian tourist coast and the propaganda of Tunisia's "economic miracle".
(10) James Clapper , the director of national intelligence, is said to talk nearly every day with the head of US Central Command’s intelligence wing, Army Major General Steven Grove – “which is highly, highly unusual”, according to a former intelligence official.
(11) So I say to them: ‘Your challenge, guys, is actually to play it straight.’” At Highbury Grove the experiment is in its early stages.
(12) The principal catching site was a palm grove surrounded by forest 3 km from the village.
(13) Previous studies from this laboratory have demonstrated that the electrical excitability of nigro-striatal dopaminergic terminals is reduced by the dopaminomimetics apomorphine and amphetamine and is increased by the dopamine antagonists haloperidol, fluphenazine and sulpiride (Groves, Fenster, Tepper, Nakamura, and Young 1981; Tepper, Nakamura, Young and Groves 1984).
(14) Biological monitoring was performed for one year at the site of a sugar cane grove on the left bank of the river.
(15) The widespread use of herbicides in Florida citrus groves raises the possibility of residue accumulation following repeated applications.
(16) At Ladbroke Grove, shortly after the flame had passed from the bus to relay runners, it was almost wrestled from the hands of TV presenter Konnie Huq.
(17) Two men in balaclavas stood in an olive grove, firing shot after earsplitting shot into the air, their M16s angled a bit too low for comfort.
(18) According to his agent Jonathan Groves, he conducted there "every year since he made his debut in 1952 until his final appearances with Rigoletto in 2005".
(19) However, the political debate fails to reflect that contemporary reality in any meaningful way.” The report , by Ford and Ruth Grove-White from the Migrants’ Rights Network, is published on Thursday and based on an analysis of data from the census in 2001 and 2011 and the national statistics agency.
(20) Rotblat overheard the military director of the Manhattan Project, Lieutenant General Richard Groves, say at a wartime dinner party: "You realise of course that the main purpose of this project is to subdue the Russkies."