(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Hole
Definition:
(a.) Whole.
(n.) A hollow place or cavity; an excavation; a pit; an opening in or through a solid body, a fabric, etc.; a perforation; a rent; a fissure.
(n.) An excavation in the ground, made by an animal to live in, or a natural cavity inhabited by an animal; hence, a low, narrow, or dark lodging or place; a mean habitation.
(n.) To cut, dig, or bore a hole or holes in; as, to hole a post for the insertion of rails or bars.
(n.) To drive into a hole, as an animal, or a billiard ball.
(v. i.) To go or get into a hole.
Example Sentences:
(1) But the wounding charge in 2010 has become Brown's creation of a structural hole in the budget, more serious than the cyclical hit which the recession made in tax receipts, at least 4% of GDP.
(2) Undaunted by the sickening swell of the ocean and wrapped up against the chilly wind, Straneo, of Woods Hole Oceanographic Institution, one of the world's leading oceanographic research centres, continues to take measurements from the waters as the long Arctic dusk falls.
(3) The speed of visiting holes and the development of a preferred pattern of hole-visits did not influence spatial discrimination performance.
(4) Macular holes, formerly believed to be rare in these injuries, were found in two of the five patients.
(5) Jane's life clearly still has a massive Spike-shaped hole in it.
(6) It would cost their own businesses hundreds of millions of pounds in transaction costs, it would blow a massive hole in their balance of payments, it would leave them having to pick up the entirety of UK debt.
(7) Bar manager Joe Mattheisen, 66, who has worked at the hole-in-the-wall bar since 1997, said the bar has attracted younger, straighter crowds in recent years.
(8) Guzmán was sent to Altiplano high-security prison, 56 miles outside Mexico City, but in July 2015, he absconded again, squeezing through a hole in his shower floor then fleeing on a modified motorbike through a mile-long tunnel fitted with lights and a ventilation system.
(9) If the attacker's plan was to make important ideas disappear down the memory hole, it looks as if it has backfired spectacularly.
(10) In contrast, eyes with macular holes had a greater reduction in the steady-state VEP amplitude than eyes with optic neuritis.
(11) An 8-French right Judkins guiding catheter with a single side hole (USCI), a 3.0 mm balloon dilatation catheter (ACS), and a 0.018 high torque floppy guide wire (ACS) were used.
(12) Four hours p.i., a clustering of the p60 antigen and, 12 h p.i., a formation of finger-like holes, penetrating the nucleus, occurred.
(13) Campbell, Ann E. (Woods Hole Oceanographic Institution, Woods Hole, Mass.
(14) We don't whip homeless vagrants out of town any more, or burn big holes in their ears, as in the brutish 16th century.
(15) The chancellor deliberately made cautious assumptions for the deficit in the budget, but the 5.6% contraction in the economy has blown an even bigger hole in the public finances than feared in April.
(16) He avoided everyone he didn't want to see when he was in Hong Kong, the first place he escaped to, and for several weeks he remained beyond the reach of the world's media, and doubtless a small army of spies, while holed up in a hotel room in the transit area of Moscow's Sheremetyevo airport.
(17) There were no thromboses among infants with long end-hole catheters while infants with short end-hole catheters had thrombosis in 26%, long side-hole catheters in 33% and short side-hole catheters in 64%.
(18) The animal model was induced by left frontal burr hole opening and inoculation of a small piece of G-XII glioma tissue to 6- to 8-week-old rats.
(19) In February last year the BBC was forced to apologise to the Mexican ambassador after a joke made by the three presenters that the nation's cars were like the people "lazy, feckless, flatulent, overweight, leaning against a fence asleep looking at a cactus with a blanket with a hole in the middle on as a coat".
(20) Thus, VP2 and VP5 together form a continuous layer around the inner shell except for holes on the 5-fold axis.