(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Hollow
Definition:
(a.) Having an empty space or cavity, natural or artificial, within a solid substance; not solid; excavated in the interior; as, a hollow tree; a hollow sphere.
(a.) Depressed; concave; gaunt; sunken.
(a.) Reverberated from a cavity, or resembling such a sound; deep; muffled; as, a hollow roar.
(a.) Not sincere or faithful; false; deceitful; not sound; as, a hollow heart; a hollow friend.
(n.) A cavity, natural or artificial; an unfilled space within anything; a hole, a cavern; an excavation; as the hollow of the hand or of a tree.
(n.) A low spot surrounded by elevations; a depressed part of a surface; a concavity; a channel.
(v. t.) To make hollow, as by digging, cutting, or engraving; to excavate.
(adv.) Wholly; completely; utterly; -- chiefly after the verb to beat, and often with all; as, this story beats the other all hollow. See All, adv.
(interj.) Hollo.
(v. i.) To shout; to hollo.
(v. t.) To urge or call by shouting.
Example Sentences:
(1) No evidence for consumptive coagulopathy was noted in the absence of heparin during hemodialysis with cuprophane hollow fiber dialyzers.
(2) The buccal glands of adults of the Southern Hemisphere lamprey Geotria australis consist of a pair of small, bean-shaped, hollow sacs, embedded within the basilaris muscle in the region below the eyes and to either side of the piston cartilage.
(3) The whole thing has made me feel hollow inside,” says one Tory MP.
(4) "The hollow words of praise from the home secretary are meaningless today.
(5) In order to clarify the role of dialyzer geometry, the effect of hollow-fiber versus flat-sheet dialyzers and of different surface areas on C3a generation and leukocyte degranulation was investigated.
(6) A significant improvement in the precision of the hollow cathode as an emission source is reported.
(7) These include a redistribution of the neurons that originally were in barrel sides; a reduction in the neuropil between the neurons that originally were within hollows; and differential growth of layer IV dendrites.
(8) In layer IV high NMDA receptor densities were specifically confined to the barrel hollows.
(9) This study presents results from in vitro and in vivo experiments in rodents by the use of a PEEK-hollow fiber.
(10) Pathogenetic and etiologic points of view of the perforation of dermoid cysts of the small pelvis into adjacent hollow organs are discussed in short.
(11) This article describes the presurgical evaluation and surgical procedures for the treatment of partially edentulous patients with ITI hollow-screw implants.
(12) B43 MoAb was produced in vitro by hollow fiber technology and purified to homogeneity by affinity chromatography.
(13) Despite a 30% rate of luminal blockage in stents retrieved after indwelling times up to 3 months, the incidence of clinical obstruction in stented tracts up to 3 months was 4%, confirming other reports that significant urine flow occurs around rather than through hollow, vented stents.
(14) attack of pain, retroperitoneal hematoma, hemoperitoneum, rupture into a hollow viscus, infective aneurysm.
(15) Produced by Morrissey and Johnny Marr with Stephen Street, MIM sounds more full-blooded than anything they had previously recorded – notably Hatful of Hollow , the compilation that preceded it.
(16) Hollowing out legacy media’s revenues while using its content, “ digital colonialism ” and issues of censorship have plagued the company in 2016.
(17) In one clothes shop, with racks of discounted Calvin Klein and DKNY, the manager, Sav, explains what's happened: "In this crisis, the middle classes have been hollowed out."
(18) We also show that the laminin-derived synthetic peptide YIGSR contains sufficient information to induce single endothelial cells to form ring-like structures surrounding a hollow lumen, the basic putative unit in the formation of capillaries.
(19) The story of the past 30 years has been the relentless hollowing-out of industrial Britain, the single biggest change to the British economy in the postwar era.
(20) At the basis of each pilus, a cell wall differentiation was observed appearing, in face-on-view, as a ring-like structure made up of subunits, and in side-on view as a hollow cylinder penetrating through the cell wall.