(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Location
Definition:
(n.) The act or process of locating.
(n.) Situation; place; locality.
(n.) That which is located; a tract of land designated in place.
(n.) A leasing on rent.
(n.) A contract for the use of a thing, or service of a person, for hire.
(n.) The marking out of the boundaries, or identifying the place or site of, a piece of land, according to the description given in an entry, plan, map, etc.
Example Sentences:
(1) First results let us assume that clinically silent TIAs also (in analogy to clinically silent brain infarctions) could be detected and located.
(2) Phospholipid methylation in human EGMs is distinctly different from that in rat EGMs (Hirata and Axelrod 1980) in that the human activity is not Mg++-dependent, and apparent methyltransferase I activity is located in the external membrane surface.
(3) An unsaturated fatty acid auxotroph of Escherichia coli was grown with a series of cis-octadecenoate isomers in which the location of the double bond varied from positions 3 to 17.
(4) Two small populations of GLY + neurons were observed outside of the named nuclei of the SOC; one was located dorsal to the LSO, near its dorsal hilus, and the other was identified near the medial pole of the LSO.
(5) Brain damage may be followed by a number of dynamic events including reactive synaptogenesis, rerouting of axons to unusual locations and altered axon retraction processes.
(6) Bipolar derivations with the maximum PSE always included the locations with the maximum PSE obtained from a linked ears reference.
(7) Until recently, the control was thought to be governed by single, dominant genes, located within the I region of the H-2 complex.
(8) Univariate and multivariate analyses indicated previous LBP or back pain in another location of the spine were strongly associated with LBP during the study year.
(9) Other DNase I hypersensitive sites located adjacent to the S14 cap site at -65 to -265 base pairs (Hss-1) or upstream at -1.3 kb (Hss-2), -2.1 kb (Hss-3'), -5.3 kb (Hss-4), and -6.2 kb (Hss-5) remained unaffected by changes in S14 gene transcription.
(10) On the basis of primary sequence homology with other known Pseudomonas lipases, a number of putative active site residues located in conserved areas were found.
(11) Likewise, they had little or no effects on the fluorescence anisotropy of TMA-DPH, which is also thought to be located in the interfacial region of the lipid bilayer, either when the probe was located in the outer layer of the plasma membrane or when the probe was located in the inner membrane compartment.
(12) Females were killed at various times after the onset of mating or artificial insemination, oviducts were fixed and sectioned serially, and spermatozoa were counted individually as to their location in the oviduct.
(13) The masses were solitary and located in the retroperitoneum (five cases), mediastinum (one case), and axilla (one case).
(14) The family history and associated anomalies were recorded and particular attention was paid to temperature gradients and neurocirculatory deficits with respect to band location.
(15) The gene, which is located at chromosome XIII, is transcribed as a mRNA of about 2.7 kilobases, and the amount of message has been found to increase 3- to 4-fold during the culture.
(16) The first experiment gave good results, although only one participant had any previous experience of hinge axis location, and it is debatable whether or not this experience is necessary before satisfactory results can be obtained.
(17) The hypothalamic VIP mRNA was located mainly in the SCN.
(18) Comparisons of ICR locations were made between flexion and extension, between left and right limbs, and between living and dead dogs, using analysis of variance.
(19) The fine needle aspiration cytology features of twelve peripherally located bronchioloalveolar cell carcinomas of the lung diagnosed by fine needle aspiration biopsy are described.
(20) Thirteen patients had had a posterior dislocation with an associated fracture of the femoral head located either caudad or cephalad to the fovea centralis (Pipkin Type-I or Type-II injury), one had had a posterior dislocation with associated fractures of the femoral head and neck (Pipkin Type III), two had had a posterior dislocation with associated fractures of the femoral head and the acetabular rim (Pipkin Type IV), and three had had a fracture-dislocation that we could not categorize according to the Pipkin classification.