(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Long
Definition:
(superl.) Drawn out in a line, or in the direction of length; protracted; extended; as, a long line; -- opposed to short, and distinguished from broad or wide.
(superl.) Drawn out or extended in time; continued through a considerable tine, or to a great length; as, a long series of events; a long debate; a long drama; a long history; a long book.
(superl.) Slow in passing; causing weariness by length or duration; lingering; as, long hours of watching.
(superl.) Occurring or coming after an extended interval; distant in time; far away.
(superl.) Extended to any specified measure; of a specified length; as, a span long; a yard long; a mile long, that is, extended to the measure of a mile, etc.
(superl.) Far-reaching; extensive.
(superl.) Prolonged, or relatively more prolonged, in utterance; -- said of vowels and syllables. See Short, a., 13, and Guide to Pronunciation, // 22, 30.
(n.) A note formerly used in music, one half the length of a large, twice that of a breve.
(n.) A long sound, syllable, or vowel.
(n.) The longest dimension; the greatest extent; -- in the phrase, the long and the short of it, that is, the sum and substance of it.
(adv.) To a great extent in apace; as, a long drawn out line.
(adv.) To a great extent in time; during a long time.
(adv.) At a point of duration far distant, either prior or posterior; as, not long before; not long after; long before the foundation of Rome; long after the Conquest.
(adv.) Through the whole extent or duration.
(adv.) Through an extent of time, more or less; -- only in question; as, how long will you be gone?
(prep.) By means of; by the fault of; because of.
(a.) To feel a strong or morbid desire or craving; to wish for something with eagerness; -- followed by an infinitive, or by after or for.
(a.) To belong; -- used with to, unto, or for.
Example Sentences:
(1) A 2.5-month-old child with cyanotic heart disease who required long-term PGE1 infusions; developed widespread periosteal reactions during the course of therapy.
(2) Arda Turan's deflected long-range strike puts Atlético back in control.
(3) Both the vitellogenesis and the GtH cell activity are restored in the fish exposed to short photoperiod if it is followed by a long photoperiod.
(4) Participants (n=165) entering a week-long outpatient education program completed a protocol measuring self-care patterns, glycosylated hemoglobin levels, and emotional well-being.
(5) The half-life of 45Ca in the various calcium fractions of both types of bone was 72 hours in both the control and malnourished groups except the calcium complex portion of the long bone of the control group, which was about 100 hours.
(6) Under blood preservation conditions the difference of the rates of ATP-production and -consumption is the most important factor for a high ATP-level over long periods.
(7) The origins of aging of higher forms of life, particularly humans, is presented as the consequence of an evolved balance between 4 specific kinds of dysfunction-producing events and 4 kinds of evolved counteracting effects in long-lived forms.
(8) The International Monetary Fund, which has long urged Nigeria to remove the subsidy, supports the move.
(9) Arthrotomy with continuous irrigation appears to be more effective in decreasing long-term residual effects than arthrotomy alone.
(10) A significant correlation was found between the amplitude ratio of the R2 and the sensitivity ratio of the rapid off-response at short and long wavelengths.
(11) Taken together these results are consistent with the view that primary CTL, as well as long term cloned CTL cell lines, exercise their cytolytic activity by means of perforin.
(12) A novel prostaglandin E2 analogue, CL 115347, can be administered transdermally on a long-term basis.
(13) Michael Caine was his understudy for the 1959 play The Long and the Short and the Tall at the Royal Court Theatre.
(14) In the German Democratic Republic, patients with scleroderma and history of long term silica exposure are recognized as patients with occupational disease even though pneumoconiosis is not clearly demonstrated on X-ray film.
(15) But that's just it - they need to be viable in the long term.
(16) Several interpretations of the results are examined including the possibility that the effects of Valium use were short-lived rather than long-term and that Valium may have been taken in anticipation of anxiety rather than after its occurrence.
(17) Variables included an ego-delay measure obtained from temporal estimations, perceptions of temporal dominance and relatedness obtained from Cottle's Circles Test, Ss' ages, and a measure of long-term posthospital adjustment.
(18) However, used effectively, credit can help you to make the most of your money - so long as you are careful!
(19) Since 1979, patients started on long-term lithium treatment at the Psychiatric Hospital in Risskov have been followed systematically with recording of clinical and laboratory variables before the start of treatment, after 6 and 12 months of treatment, and thereafter at yearly intervals.
(20) Compared with conservative management, better long-term success (determined by return of athletic soundness and less evidence of degenerative joint disease) was achieved with surgical curettage of elbow subchondral cystic lesions.