(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Mill
Definition:
(n.) A money of account of the United States, having the value of the tenth of a cent, or the thousandth of a dollar.
(n.) A machine for grinding or comminuting any substance, as grain, by rubbing and crushing it between two hard, rough, or intented surfaces; as, a gristmill, a coffee mill; a bone mill.
(n.) A machine used for expelling the juice, sap, etc., from vegetable tissues by pressure, or by pressure in combination with a grinding, or cutting process; as, a cider mill; a cane mill.
(n.) A machine for grinding and polishing; as, a lapidary mill.
(n.) A common name for various machines which produce a manufactured product, or change the form of a raw material by the continuous repetition of some simple action; as, a sawmill; a stamping mill, etc.
(n.) A building or collection of buildings with machinery by which the processes of manufacturing are carried on; as, a cotton mill; a powder mill; a rolling mill.
(n.) A hardened steel roller having a design in relief, used for imprinting a reversed copy of the design in a softer metal, as copper.
(n.) An excavation in rock, transverse to the workings, from which material for filling is obtained.
(n.) A passage underground through which ore is shot.
(n.) A milling cutter. See Illust. under Milling.
(n.) A pugilistic.
(n.) To reduce to fine particles, or to small pieces, in a mill; to grind; to comminute.
(n.) To shape, finish, or transform by passing through a machine; specifically, to shape or dress, as metal, by means of a rotary cutter.
(n.) To make a raised border around the edges of, or to cut fine grooves or indentations across the edges of, as of a coin, or a screw head; also, to stamp in a coining press; to coin.
(n.) To pass through a fulling mill; to full, as cloth.
(n.) To beat with the fists.
(n.) To roll into bars, as steel.
(v. i.) To swim under water; -- said of air-breathing creatures.
Example Sentences:
(1) The only sign of life was excavators loading trees on to barges to take to pulp mills.
(2) When reformist industrialist Robert Owen set about creating a new community among the workers in his New Lanark cotton-spinning mills at the turn of the nineteenth century, it was called socialism, not corporate social responsibility.
(3) The Cambridge-based couple felt ignored when tried to raise the alarm about the way their business – publisher Zenith – was treated by Lynden Scourfield, the former HBOS banker jailed last week, and David Mills’ Quayside Corporate Services.
(4) This is a report on a male patient of 71 years of age who had been a graphite mill worker for about 14 years.
(5) What seems beyond doubt is that Koussa has long represented the old guard which for decades was close to Gaddafi, but which – if the Tripoli rumour mill is to be believed – has recently been pushed aside by Gaddafi's competing sons.
(6) It obviously helps to have a waterfront, red bricks and cotton mills,” said Professor Karel Williams at Manchester Business School.
(7) Airborne endotoxin also was estimated in the different work places of the mill.
(8) 800,000 U and 1.5 mill U SK recanalized infarct-related arteries at a rate of 78%.
(9) A cross-sectional study of 315 animal feed workers was undertaken in 14 animal feed mills in the Netherlands.
(10) A study was conducted to estimate the exposure-response relationship for tremolite-actinolite fiber exposure and radiographic findings among 184 men employed at a Montana vermiculite mine and mill.
(11) Mills said the operators' maps, which he copied, showed the mark was to be the site of a detonation.
(12) Two hundred and seventy-one men seen in 1963, who worked in a pulp and a paper mill, were followed up ten years later, in 1973.
(13) No significant changes in respiratory function or bronchial responsiveness related to exposure to hydrogen sulphide in the pulp mill workers were found.
(14) This was caused by ingestion of branches of the alder buckthorn (Frangula alnus (mill.)
(15) To create a new bank, which we understand is an option, which could be called Glyn Mills, is ridiculously back to the future.
(16) Under an abandoned flour mill and in a "howling, freezing" power station, he had "eaten sandwiches and coffee coated thick with dust".
(17) Non-occupational exposure of the population living in the vicinity of the serpentine mining and processing mill in Nasławice was assessed.
(18) The concentration of hyaluronan was measured in the bronchoalveolar lavage fluid (BALF) of 18 control subjects and 27 workers from the asbestos mills and mines of Québec, 9 without asbestosis and 18 with asbestosis.
(19) The erythrocytic stages of Plasmodium falciparum from Aotus trivirgatus were grown in Mill Hill medium.
(20) Video of flooding in Barcombe Mills, East Sussex 12.07pm GMT Lord Smith of the Environment Agency due to speak from Somerset soon.