(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Moat
Definition:
(n.) A deep trench around the rampart of a castle or other fortified place, sometimes filled with water; a ditch.
(v. t.) To surround with a moat.
Example Sentences:
(1) Khao Soi Khun Yai, Sri Poom Road, next to Wat Kuan Kama, Old City, North Moat; meal for two £1.60-£3 Warorot evening market Facebook Twitter Pinterest You could pick other food markets (Sompet, Thanin, Chiang Mai Gate, Chang Phuak Gate) and be as deliriously sated, but the night-time street food at Warorot remains special to me.
(2) When you read of such sentences, remember that this is the same country in which – just a few years ago – over 300 parliamentarians were found to have claimed expenses to which they weren’t entitled; hundreds of thousands handed over to some of the richest people in the country for duck houses, moat repairs and heating their stables.
(3) Bars and cages are out; moats and discreet electric fences are in.
(4) He stepped down from contesting the 2010 election after it emerged he had claimed £2,200 for the cleaning of the moat at his 13th-century manor house.
(5) It is believed that they went across the small moat to the north of the centre, and got as far as the car park, where they shouted "Our world is not for sale" before being arrested.
(6) An Englishman's home is his castle, and that castle now includes a moat to keep the peasants out.
(7) He informed the housing association retrospectively, and Moat says it "reluctantly" gave permission for the sub-let to run its two-year term, which ends on 13 February.
(8) It sits, forlorn, in a moat of open space, like a lone domino.
(9) Douglas Hogg , who was ordered by the Tory party leadership to repay the £2,200 cost of clearing his moat, politely declined.
(10) Missing correspondence between MPs and Commons officials must have given most of the game away regarding Tory expense claims for moat cleaning and duck houses.
(11) Yet I recall influential voices – including in cabinet – arguing that rather than confront the problem (under IMF supervision), Britain should pull up the drawbridge behind the moat of the English Channel.
(12) Facebook, which still has sites eulogising murderer Raoul Moat and Holocaust deniers, said it drew the line on groups that attack others, a bold move considering the site's WikiLeaks page boasts more than 1.3 million supporters.
(13) We get lost on our way out and end up standing in the darkness, trapped by a maze of brutalist architecture and a large moat, laughing at our inability to navigate one of the most iconic structures in London.
(14) Minimal bodily adjustment was necessary for free foraging, whereas discrete food presentations on land (DFP-land) and in a moat (DFP-moat) promoted a gross reorientation of the animal's entire body.
(15) "Is it really true that a Romanian side once built a moat filled with crocodiles to stop the crowd from invading the pitch?"
(16) And they have dug a legal moat around the charmed circle, criminalising, for example, the squatting of empty buildings and most forms of peaceful protest.
(17) Activists tried a variety of methods to enter the conference centre, approaching in large groups from several directions and, at one point, sending several hundred people running with seven giant lilos to bridge a moat next to the centre.
(18) Elizabeth Austerberry, the chief executive of Moat, said: “These people are not going to go away.
(19) The couple can't understand why Moat won't allow them to continue sub-letting for a further period.
(20) When he wasn't writing, he was usually swimming, most often in his moat, or wallowing in the massive cast-iron bath that lived at the back of the house.