(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Music
Definition:
(n.) The science and the art of tones, or musical sounds, i. e., sounds of higher or lower pitch, begotten of uniform and synchronous vibrations, as of a string at various degrees of tension; the science of harmonical tones which treats of the principles of harmony, or the properties, dependences, and relations of tones to each other; the art of combining tones in a manner to please the ear.
(n.) Melody; a rhythmical and otherwise agreeable succession of tones.
(n.) Harmony; an accordant combination of simultaneous tones.
(n.) The written and printed notation of a musical composition; the score.
(n.) Love of music; capacity of enjoying music.
(n.) A more or less musical sound made by many of the lower animals. See Stridulation.
Example Sentences:
(1) National policy on the longer-term future of the services will not be known until the government publishes a national music plan later this term.
(2) This week MediaGuardian 25, our survey of Britain's most important media companies, covering TV, radio, newspapers, magazines, music and digital, looks at BSkyB.
(3) Living by the "Big River" as a child, Cash soaked up work songs, church music, and country & western from radio station WMPS in Memphis, or the broadcasts from Nashville's Grand Ole Opry on Friday and Saturday evenings.
(4) Subjects' musical backgrounds were evaluated with a survey questionnaire.
(5) On raw music scores a sex-linked, time-of-day-induced priming effect was due to the prior presentation of CVs--that is, cognitive priming.
(6) Lady Gaga is not the first big music star to make a new album available early to mobile customers.
(7) He had links to networks including the Hammerskin Nation and was involved in an underground music scene often referred to as "white power music" or "hate rock".
(8) Strict fundamentalists oppose music in any form as a sensual distraction - the Taliban, of course, banned music in Afghanistan.
(9) Amplitude of the musical vibrations decreased by inhalation of amyl nitrite, but increased by infusion of methoxamine.
(10) While a clearcut relationship cannot be established between heavy metal music and destructive behavior, evidence shows that such music promotes and supports patterns of drug abuse, promiscuous sexual activity, and violence.
(11) For Burroughs, who had been publishing ground-breaking books for 20 years without much appreciable financial return, it was association with fame and the music industry, as well as the possible benefits: a wider readership, film hook-ups and more money.
(12) Much of the week's music isn't actually sanctioned by the festival, with evenings hosted by blogs, brands, magazines, labels and, for some reason, Cirque du Soleil .
(13) The musical would begin previews in Chicago on December 21, and move to Broadway in February.
(14) His coding talent attracted attention early: a music-recommendation program he wrote as a teenager brought approaches from both Microsoft and AOL.
(15) Thanks to the groundbreaking technology and heavy investment of a new breed of entertainment retailers offering access services, we are witnessing a revolution in the entertainment industry, benefitting consumers, creators and content owners alike.” ERA acts as a forum for the physical and digital retail sectors of music, and represents over 90% of the of the UK’s entertainment retail market.
(16) In film, music videos and TV shows, especially those traditionally consumed by a young demographic, we are used to seeing women stripping and frolicking with one another.
(17) If we’ve a duty to pass folk music on, we should also bring it up to date and make it relevant to our times,” he says.
(18) Changes to the Mac Pro desktop computer are also expected, as is a new music streaming service .
(19) "What this proves is that the way Bowie engineered his comeback was a stroke of genius," said music writer Simon Price.
(20) Was that misreading the mood music of the referendum?” He claimed that many Tories had expressed their anger directly to Rudd about the controversial policy, which has since been watered down.