(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Narrow
Definition:
(superl.) Of little breadth; not wide or broad; having little distance from side to side; as, a narrow board; a narrow street; a narrow hem.
(superl.) Of little extent; very limited; circumscribed.
(superl.) Having but a little margin; having barely sufficient space, time, or number, etc.; close; near; -- with special reference to some peril or misfortune; as, a narrow shot; a narrow escape; a narrow majority.
(superl.) Limited as to means; straitened; pinching; as, narrow circumstances.
(superl.) Contracted; of limited scope; illiberal; bigoted; as, a narrow mind; narrow views.
(superl.) Scrutinizing in detail; close; accurate; exact.
(superl.) Formed (as a vowel) by a close position of some part of the tongue in relation to the palate; or (according to Bell) by a tense condition of the pharynx; -- distinguished from wide; as e (eve) and / (f/d), etc., from i (ill) and / (f/t), etc. See Guide to Pronunciation, / 13.
(n.) A narrow passage; esp., a contracted part of a stream, lake, or sea; a strait connecting two bodies of water; -- usually in the plural; as, The Narrows of New York harbor.
(v. t.) To lessen the breadth of; to contract; to draw into a smaller compass; to reduce the width or extent of.
(v. t.) To contract the reach or sphere of; to make less liberal or more selfish; to limit; to confine; to restrict; as, to narrow one's views or knowledge; to narrow a question in discussion.
(v. t.) To contract the size of, as a stocking, by taking two stitches into one.
(v. i.) To become less broad; to contract; to become narrower; as, the sea narrows into a strait.
(v. i.) Not to step out enough to the one hand or the other; as, a horse narrows.
(v. i.) To contract the size of a stocking or other knit article, by taking two stitches into one.
Example Sentences:
(1) The PSB dioxygenase system displayed a narrow substrate range: none of 18 sulphonated or non-sulphonated analogues of PSB showed significant substrate-dependent O2 uptake.
(2) Comparison of developmental series of D. merriami and T. bottae revealed that the decline of the artery in the latter species is preceded by a greater degree of arterial coarctation, or narrowing, as it passes though the developing stapes.
(3) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(4) In all immunized rabbits the antisera obtained with the 7 alpha-derivative had a higher affinity and a narrower specificity than the antiserum obtained with the 7 beta-derivative.
(5) That is, he believes, to look at massively difficult, interlocking problems through too narrow a lens.
(6) Photograph: AP Reasons for wavering • State relies on coal-fired electricity • Poor prospects for wind power • Conservative Democrat • Represents conservative district in conservative state and was elected on narrow margins Campaign support from fossil fuel interests in 2008 • $93,743 G K Butterfield (North Carolina) GK Butterfield, North Carolina.
(7) Their narrowed processes pass at a common site through the muscle layer and above this layer again slightly widen and project above the neighbouring tegument.
(8) These patients did not have narrow anterior chamber angles preoperatively, and several were aphakix with surgical iris colobomas.
(9) The linewidths of the methionine Cepsilon resonances are narrowed by increasing temperature according to an Arrhenius energy of activation of nearly 3 kcal.
(10) The detergent lauryl maltoside abolishes respiratory control and proton ejection by cytochrome c oxidase-containing proteoliposomes over a narrow concentration range.
(11) Per-rotational nystagmus was recorded in rabbits with unilaterally narrowed vertebral arteries or following unilateral cervical sympathectomies.
(12) However, the narrow range of the ED50 suggests relatively little variation in the response of the different isolates in vivo and similarly small variation was also noted in some of the tests in vitro.
(13) Eight patients had glaucoma only in one eye; three narrow-angle glaucoma, three primary open-angle glaucoma and two secondary glaucoma.
(14) In the fifth case the vein was too narrow to allow catheterization.
(15) It was found that within the dorsal part of the well known pressor area there is a narrow strip, 2.5 mm lateral from the mid line, starting ventral to the inferior colliculus and ending in the medulla close to the floor of the IV ventricle, from which vasodilatation in skeletal muscles is selectively obtained.
(16) Each border was within a region of 11 nucleotides and gave rise to a narrow size range (1248-1261 nucleotides) for the population of 22 subgenomic DNAs.
(17) These factors include narrowing of septal arteries and the artery to the atrioventricular node, preservation of fetal anatomy with dispersion in the atrioventricular node and His bundle, fibrosis of the sinus node, clefts in the septum, multiple atrioventricular pathways and massive myocardial infarction.
(18) Time suggests that the FBI inquiry has been extended from a relatively narrow look at alleged malpractices by News Corp in America into a more general inquiry into whether the company used possibly illegal strongarm tactics to browbeat rival firms, following allegations of computer hacking made by retail advertising company Floorgraphics.
(19) These three activities, appearing within a narrow range of molecular weights, different from those of other known lymphokines, suggest the existence of a distinct class of lymphokine mediators with the common function of influencing functional properties of tumor cells.
(20) The narrow intercellular ridge is smooth, whereas the epithelial cells have small cytoplasmic knobs between the cilia.