(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Plough
Definition:
(n. & v.) See Plow.
(n.) A well-known implement, drawn by horses, mules, oxen, or other power, for turning up the soil to prepare it for bearing crops; also used to furrow or break up the soil for other purposes; as, the subsoil plow; the draining plow.
(n.) Fig.: Agriculture; husbandry.
(n.) A carucate of land; a plowland.
(n.) A joiner's plane for making grooves; a grooving plane.
(n.) An implement for trimming or shaving off the edges of books.
(n.) Same as Charles's Wain.
(v. t.) To turn up, break up, or trench, with a plow; to till with, or as with, a plow; as, to plow the ground; to plow a field.
(v. t.) To furrow; to make furrows, grooves, or ridges in; to run through, as in sailing.
(v. t.) To trim, or shave off the edges of, as a book or paper, with a plow. See Plow, n., 5.
(n.) To cut a groove in, as in a plank, or the edge of a board; especially, a rectangular groove to receive the end of a shelf or tread, the edge of a panel, a tongue, etc.
(v. i.) To labor with, or as with, a plow; to till or turn up the soil with a plow; to prepare the soil or bed for anything.
Example Sentences:
(1) Committing to ploughing a lone furrow without international agreement will damage our economy for little or no environmental benefit.
(2) Yet out-of-touch ministers have ploughed on regardless and claimed this is a 'triumph'.
(3) He would much rather money be ploughed into renewable energy sources.
(4) Child benefit is to be withdrawn from families as soon as one parent hits earnings of £44,000, but any tapering would be costly and require ploughing money back via child tax credits.
(5) The year before that, a video of a huge truck bomb ploughing into Salerno base in Khost province upended Nato reports of a relatively minor attack in which no one was killed.
(6) Facebook Twitter Pinterest A farm worker ploughing a field in Blackwater.
(7) He said the government would also plough money into the expansion of solar heating systems.
(8) The retailer said annual profits were likely to be poorer than expected as it had ploughed millions of pounds into a multimedia advertising campaign and taken on hundreds more vans to back a new delivery service before Black Friday, which falls on 27 November this year, but could not be sure how shoppers would respond.
(9) PMQs ploughs on regardless, in part because both sides know the weekly exchanges shape backbench morale, in part because one side will always think it gains an advantage over the other at such sessions, and in part because too many MPs are afraid of radical parliamentary change.
(10) Molemo "Jub Jub" Maarohanye, pictured right, and his friend, Themba Tshabalala, are accused of killing four schoolboys after racing two Mini Coopers in the streets of Soweto only to lose control and plough into a group of children.
(11) This month the concessions are being worked at a breakneck pace, with giant tractors and heavy machinery clearing trees, draining swamps and ploughing the land in time to catch the next growing season.
(12) The housing crisis tells you a lot about British society: springing from a pathological middle class obsession with home ownership, the spike in houses prices is seen as earned, not incidental: most people now expect to make a profit on housing, and the fact people like the Blairs plough cash in as an investment should be a warning sign.
(13) Some £60m was ploughed into refurbishments in 2013 with plans to invest the same amount in the new financial year.
(14) The article also reported that "since leaving No 10, Brown has received more than £2m in fees and expenses — although this has all been ploughed back into his public and charitable activities".
(15) The latter are grown in fields on which oil-based fertilisers have been sprayed and which are ploughed by tractors that burn diesel.
(16) The committee is planning to plough the money saved into CCTV cameras for the park and will try again next year to raise the money for a display.
(17) After Unprofor approval,” says Van der Wind, “the fuel was delivered in Bratunac [the Bosnian Serb HQ outside Srebrenica] after the arrival of a logistical convoy.” The UN petrol was used, he says, to fuel transport of men and boys to the killing fields, and bulldozers to plough the 8,000 corpses into mass graves.
(18) Half will be ploughed back into frontline public services, leaving £6bn to fund a smaller tax-take from NI than under a fourth-term Labour government.
(19) Kevyn Orr will be gone in five and a half months, and so I’m able to, I think, deliver results on the lights, deliver results on EMS response times, deliver results on the blight, getting a little bit better at the snow-ploughing, and we’re just going to keep building on that.” Other notable moments: Detroit was slammed by heavy winter storms, making it the snowiest winter on record since 1880.
(20) All the profits from sales are ploughed back into providing skills training and setting up new retail outlets.