(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Rebate
Definition:
(v. t.) To beat to obtuseness; to deprive of keenness; to blunt; to turn back the point of, as a lance used for exercise.
(v. t.) To deduct from; to make a discount from, as interest due, or customs duties.
(v. i.) To abate; to withdraw.
(n.) Diminution.
(n.) Deduction; abatement; as, a rebate of interest for immediate payment; a rebate of importation duties.
(n.) A rectangular longitudinal recess or groove, cut in the corner or edge of any body; a rabbet. See Rabbet.
(n.) A piece of wood hafted into a long stick, and serving to beat out mortar.
(n.) An iron tool sharpened something like a chisel, and used for dressing and polishing wood.
(n.) A kind of hard freestone used in making pavements.
(v. t.) To cut a rebate in. See Rabbet, v.
Example Sentences:
(1) UK negotiatiors, though, fought back hard -- thus Cameron's fighting talk in his press conference ( see 12.46pm ) 12.49pm BST Open Europe tweets Cameron's tough talk on the rebate: Open Europe (@OpenEurope) Cameron: in Feb we reached a clear deal rebate would remain unchanged, since then some have tried to question this agreement June 28, 2013 Open Europe (@OpenEurope) Cameron: I defeated these attempts to change the rebate, it will remain unchanged for this long term budget June 28, 2013 12.46pm BST David Cameron press conference underway In Brussels, David Cameron is holding his press conference now.
(2) Senior government sources have confirmed the budget razor gang has the fuel tax credit (formerly known as the diesel fuel rebate) “firmly in its sights” – a scheme that rebates miners and farmers and others for the off-road use of diesel.
(3) Established methods of drug product management, such as formularies and MACs, were most commonly reported by HMOs; however, nearly half reported using new approaches, including contracts with manufacturers, incentives, such as discounts and rebates based on use, and exclusive or preferred status.
(4) If there had been no rebate, the UK would have paid more to the common budget than the other countries.
(5) We will retain the UK rebate, but it must be bearable for the other net contributors."
(6) He also launched a strong attack on Labour, which brokered an above-inflation increase and placed the British EU rebate on the table when it led the last budget negotiations during the 2005 UK presidency of the EU.
(7) Although it will include some $150bn in tax relief for people on low and middle incomes, the Obama administration's emphasis on spending marks a shift from the approach of George Bush, who tried to stimulate the economy over the summer simply by sending out millions of tax rebate cheques.
(8) The deputy prime minister and leader of the Nationals, Warren Truss, said: “Nothing that comes out of Paris will affect or have any impact on the diesel fuel rebate.” George Christensen, a Liberal National party MP based in regional Queensland, said signing the proposed communique would be “madness”.
(9) Banks and insurance companies regulated by the Bank of England are receiving a £8m rebate on the fees they pay to fund the banking watchdog – partly as a result of a fine imposed on Royal Bank of Scotland .
(10) As Guardian Australia reported, the government was also seriously considering changes to the rebate paid to farmers and miners for the off-road use of diesel, but after fierce lobbying from both sectorsit is understood to have dropped the idea.
(11) Brussels has never liked the UK’s rebate and it seems unlikely an independent Scotland would be allowed to keep a share of it.
(12) It would approach EU negotiations on the basis of "continuity of effect", meaning that it would expect the provisions that apply to the UK (ie, euro opt-out, the rebate) to continue to apply.
(13) The people who are the super-super-rich buying their houses for £140m, this is not necessarily going to affect them because they have got their tax rebates and their amazing accountants.
(14) Cameron showed he would fight hard to retain the rebate when he was asked on Wednesday by the Tory MP David Nuttall to give a commitment that he would not agree to further reductions.
(15) Following Money's intervention, HomeServe rang Rayner, explained why his premium had risen, and gave him a £100 rebate.
(16) All he is doing is simply counting the rebate that was due anyway, a rebate that was never in doubt, trying to fool people into thinking the bill has been halved.
(17) It has emerged that ministers are considering how to persuade most of the country's 27m homeowners to take part in the flagship scheme - which could lead to incentives such as a rebate on council tax or stamp duty.
(18) Lawyers acting on behalf of three jobseekers including Cait Reilly – the unemployed graduate forced to work unpaid in Poundland – are hoping to overturn a controversial law introduced by the DWP in March which allowed the department to ignore court judgments awarding more than £100m in benefits rebates to a quarter of a million jobseekers.
(19) The changes to rebates for short consultations were part of the government’s “plan B” for Medicare , after Abbott and Dutton conceded in December that the budget policy to introduce a co-payment would not pass the Senate.
(20) This could begin as early as daycare, with accredited agencies being funded to provide children aged one to four with specialty education about water familiarisation and general water safety – including teaching toddlers how to ‘swim to the side to stay alive’.” Hart called on the government to offer swimming lesson rebates to help reduce the financial burden, which can reach up to $300 per term .