(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Router
Definition:
(n.) A plane made like a spokeshave, for working the inside edges of circular sashes.
(n.) A plane with a hooked tool protruding far below the sole, for smoothing the bottom of a cavity.
Example Sentences:
(1) HIV-1 was cultured from cool aerosols and vapors generated by a 30,000 RPM spinning router tip, an instrument similar to the Midas Rex and the Stryker oscillating bone saw.
(2) Nominum said over a single day in February more than 5.3m of the routers running the feature were used to generate attack traffic in Asia.
(3) The reason this is so scary is because virtually every bit of kit that runs the internet – the machine on which you compose your emails, the tablet or smartphone with which you browse the net, the routers that pass on the data packets that comprise your email or your web search, everything – is a computer.
(4) But it is not your internet connection, your router or your computer – the internet is staging a protest.
(5) Gramofon buyers will also become Fon members, able to access the company's network of hotspots – although as with Fon's existing routers, this means "sharing a bit of Wi-Fi at home" – allowing other Fon members within range to use their internet connection.
(6) A sensible way to combat such interference would be to switch my router off for a few hours or download one of the increasing range of software packages that lock you out of Facebook and Twitter – or, like Sean French, one half of the bestselling crime writing novelist duo Nicci French — build a writing shed just out of broadband range.
(7) The lawsuit challenges the “suspicionless seizure and searching of internet traffic” by the NSA in the US that it says is done by “tapping directly into the internet backbone inside the United States – the network of high-capacity cables, switches, and routers that today carry vast numbers of Americans’ communications with each other and with the rest of the world.” The NSA’s so-called “Upstream” surveillance scheme – first revealed by the Guardian and the Washington Post – is designed to capture communications with “non-US persons” to acquire foreign intelligence information.
(8) Freedom Hosting hosted sites on the The Onion Router (Tor) network, which anonymises and encrypts traffic, masking the identity of users.
(9) At the press of a button you should be able to hear whatever content you like around your house, and it shouldn’t be a significant technological process of how to set stuff up and how to use it.” There are significant hurdles to getting to the point where “it just works”, not least the wide variety of Wi-Fi home setups which often include cheap, poor Wi-Fi routers provided by internet service providers.
(10) Or how about Cisco, whose routers have been used to build China's Great Firewall , which keeps the majority of its citizens in wilful ignorance of the opinions of the world beyond its shores?
(11) He wrote that the exemption "was created to avoid a situation in which the copies made, for example, in a router as it passes data from one machine to another, were infringing and therefore became the focus of legal actions or problems."
(12) In another case you won't need any authentication at all to compromise the whole database [by sending malicious commands to the database].” • Wifi routers could be exploited for huge internet attacks in the UK - study
(13) The Cell site was set up at the company's expense to ensure the integrity of Huawei's products, which include routers used across the UK's fibre-optic cable network.
(14) It plugs into the router and drains power, but seems to make little difference.
(15) I lock my phone and my router cable in my safe so I'm completely free from any interruption and I can spend the entire day, weekend or week reading and writing.
(16) In a post on its European Public Policy blog on 27 April, Google stated that although it does gather wifi network names (SSIDs) and identifiers (Mac addresses) for devices like network routers, it does not gather "payload" data passed through those wifi networks.
(17) Meanwhile in a quarry in Carrara outside Rome, the decorative features of the Bel temple uprights are being etched by a CNC router-engraver.
(18) For example, the recent rise in productivity in the service sector has happened mainly because it is using more advanced inputs produced in the manufacturing sector – computers, fibre-optic cables, routers, GPS machines, more fuel-efficient cars, mechanised warehouses and so on.
(19) As many as 24m routers across the world can be used by cybercriminals to launch massive attacks on internet infrastructure, while simultaneously disrupting home connections and costing communications companies dearly.
(20) It also holds great promise for cybercriminals who can use our homes' routers, televisions, refrigerators and other Internet-connected devices to launch large and distributed attacks", said Michael Osterman, principal analyst at Osterman Research.