(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Rut
Definition:
(n.) Sexual desire or oestrus of deer, cattle, and various other mammals; heat; also, the period during which the oestrus exists.
(n.) Roaring, as of waves breaking upon the shore; rote. See Rote.
(v. i.) To have a strong sexual impulse at the reproductive period; -- said of deer, cattle, etc.
(v. t.) To cover in copulation.
(n.) A track worn by a wheel or by habitual passage of anything; a groove in which anything runs. Also used figuratively.
(v. t.) To make a rut or ruts in; -- chiefly used as a past participle or a participial adj.; as, a rutted road.
Example Sentences:
(1) Our results were compared with those obtained with other therapeutical options, and it was demonstrated that prostatectomy (both retropubic and RUT) are, clinically and urodynamically, the most effective procedure in the treatment of obstructive prostate hypertrophy.
(2) Labour is in danger of being left behind, of becoming stuck in an anti-pluralist rut.
(3) Here are our tips for breaking out of the rut: Find a mentor Is there a female leader in your organisation you admire?
(4) The higher producer strain T. reesei RUT C-30 exhibited a higher conidial level of CBH II than T. reesei QM 9414.
(5) Perhaps that was the break that Swansea so badly needed to get them out of their rut.
(6) The results provide direct evidence for a primary binding contact between Rho protein and the rut segment of cro RNA and demonstrate that this binding contact remains stable when the cro RNA is serving as a cofactor for ATP hydrolysis, an observation that is consistent with a mechanism in which Rho maintains contact with the rut region while it makes additional interactions with RNA that are coupled to ATP hydrolysis.
(7) The subsequent post-rut profiles of treated bucks were characterized by lower basal plasma LH concentrations, and reduced frequency and amplitude of plasma testosterone surges.
(8) The results provide evidence for altered plasticity of synaptic morphology in memory mutants dnc and rut and suggest a role of cAMP cascade in mediating activity-dependent synaptic plasticity.
(9) We have to stick together and keep believing we are good enough to get ourselves out of this rut that we’ve been in.
(10) Elevated concentrations of SUN in adult males killed in December were attributed to an increased catabolism of muscle protein caused by low dietary intake and high energy requirements during the rut.
(11) The extreme increase in size of certain muscles in the neck in connection with the rutting season (e.g.
(12) H. pylori positivity or negativity was defined as the concordance of two of the following tests: RUT, microbiologic culture, and histologic examination on bioptic samples.
(13) Acetylcholinesterase (ACE) activity was studied by the Karnovsky-Ruts method from the 5th to the 30th day in the brain of young rats born to chronically alcoholized animals receiving ethanol for 3 to 5 months prior to conception as well as during pregnancy and breast feeding.
(14) Park at the main overlook at Goosenecks and hike south and west along the old, increasingly rutted road for about a mile out to the tip of the mesa.
(15) In prostaglandin-treated animals, progesterone concentration was high at the time of the rut and remained so until late February 1990.
(16) The Guardian’s Michael Billington said it offered “a rutting rake’s modern progress” but it lacked the “subversiveness” of Molière’s original.
(17) We show, using a filter retention assay technique, that rho protein binds with about 10-fold lower affinity to variants of cro RNA lacking both parts of rut or to normal cro RNA having one or the other part of rut bound to a complementary DNA oligonucleotide than it binds to unmodified cro RNA.
(18) The predictivity value of combined RUT and nodular antritis, whether positive or negative, was 100%.
(19) Undeniably one of the best roads in a part of the world where rutted single-lane highways still link many major cities, it joins the international airport with Colombo, the political and commercial capital.
(20) For supporters, high-speed rail is the solution to California's future transportation needs, when the state's already jammed, rutted highways and busy airports won't be enough for a population expected to hit 46 million by 2035.