(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Scratch
Definition:
(v. t.) To rub and tear or mark the surface of with something sharp or ragged; to scrape, roughen, or wound slightly by drawing something pointed or rough across, as the claws, the nails, a pin, or the like.
(v. t.) To write or draw hastily or awkwardly.
(v. t.) To cancel by drawing one or more lines through, as the name of a candidate upon a ballot, or of a horse in a list; hence, to erase; to efface; -- often with out.
(v. t.) To dig or excavate with the claws; as, some animals scratch holes, in which they burrow.
(v. i.) To use the claws or nails in tearing or in digging; to make scratches.
(v. i.) To score, not by skillful play but by some fortunate chance of the game.
(n.) A break in the surface of a thing made by scratching, or by rubbing with anything pointed or rough; a slight wound, mark, furrow, or incision.
(n.) A line across the prize ring; up to which boxers are brought when they join fight; hence, test, trial, or proof of courage; as, to bring to the scratch; to come up to the scratch.
(n.) Minute, but tender and troublesome, excoriations, covered with scabs, upon the heels of horses which have been used where it is very wet or muddy.
(n.) A kind of wig covering only a portion of the head.
(n.) A shot which scores by chance and not as intended by the player; a fluke.
(a.) Made, done, or happening by chance; arranged with little or no preparation; determined by circumstances; haphazard; as, a scratch team; a scratch crew for a boat race; a scratch shot in billiards.
Example Sentences:
(1) To test the hypothesis that EAA agonists are involved in transmission of nociceptive information in the spinal cord, we tested the effect of various opioid, sigma and phencyclidine compounds on the action of NMDA in the tail-flick, hot-plate and biting and scratching nociceptive tests.
(2) Some organization schemes concerning locomotor and scratching rhythmicity generators are considered, such as: two half-centres with reciprocal inhibitory connections and tonic excitatory influences on these half-centres: two half-centres with inhibitory-excitatory connections and tonic excitatory influences on one half-centre; ring structures consisting of more than two functional groups of neurons with excitatory and inhibitory connections between them.
(3) In an interview with the Guardian, James Hansen, the world's pre-eminent climate scientist, said any agreement likely to emerge from the negotiations would be so deeply flawed that it would be better to start again from scratch.
(4) The satisfaction derived from smoking depends not only on the pharmacological effects of nicotine but also the sensory stimulation from smoke inhalation, particularly the tracheal 'scratch'.
(5) The pathogenesis of the prolific mite population is unclear, but either a specific immunologic deficit or the inability to effectively eliminate the mites by scratching is a plausible possibility.
(6) Forty-three percent of dog bites, and 52% of cat bites-scratches were provoked, that is, happened while the victim was interacting with the animal.
(7) If the NHS was being created from scratch, primary and community care would be treated as one service.
(8) The timing of knee extensor activity within the hip cycle is different for each form of the scratch (Robertson et al., 1985); thus, the sign of the reset cannot be predicted from the timing of the stimulus relative to the knee extensor cycle.
(9) We report a patient with cat scratch disease who presented with multiple scattered nodular lesions on the legs.
(10) Application of APV to a midbody segment also reduced the magnitude of temporal summation in the scratch circuit in response to electrical stimuli delivered to the shell at 4- to 5-s intervals.
(11) Windshields, spectacles, contact lenses, lashes, an excessive tear meniscus, intraocular lens scratches, and posterior capsular opacification are possible causes that can be easily identified and treated.
(12) Ventral UVA pre-exposure did not appear to affect dorsal skin irritation as expressed by scratch marks.
(13) A rare vascular proliferation found as a skin lesion in patients suffering from the acquired immunodeficiency syndrome and sometimes referred to as epithelioid angiomatosis is believed to be a manifestation of infection by the cat scratch bacillus or a related organism.
(14) We have made Afghanistan stronger by building up from scratch strong security forces.
(15) Immunoperoxidase staining with an antiserum raised against the cat-scratch disease bacillus stained these organisms in all patients.
(16) licking, scratching, grooming, head and limb movements), a reaction termed immobility.
(17) These data suggest that hindlimb scratching induced by 5-HT agonists may not be centrally mediated but rather may be mediated by a neuronal 5-HT1A receptor localized outside the blood-brain barrier.
(18) In contrast, after weaning they showed a significant increment in the duration of face-washing, head-washing, fur licking and body-scratching.
(19) A strong correlation was found between reduction in scratching and improvement in skin status.
(20) But screens already demonstrated by GT can withstand scratches from concrete.