(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Sector
Definition:
(n.) A part of a circle comprehended between two radii and the included arc.
(n.) A mathematical instrument, consisting of two rulers connected at one end by a joint, each arm marked with several scales, as of equal parts, chords, sines, tangents, etc., one scale of each kind on each arm, and all on lines radiating from the common center of motion. The sector is used for plotting, etc., to any scale.
(n.) An astronomical instrument, the limb of which embraces a small portion only of a circle, used for measuring differences of declination too great for the compass of a micrometer. When it is used for measuring zenith distances of stars, it is called a zenith sector.
Example Sentences:
(1) Adding a layer of private pensions, it was thought, does not involve Government mechanisms and keeps the money in the private sector.
(2) Asthma is probably the commonest chronic disease in the United Kingdom, and its attendant morbidity extends outside the possible scope of the hospital sector.
(3) It comes as the museum is transforming itself in the wake of major cuts in its government funding and looking more towards private-sector funding, a move that has caused some unease about its future direction.
(4) of rats resulted in cell death and terminal degeneration in entorhinal, insular, and posterior cingulate cortices, and in the CA1, CA3 and dentate gyrus sectors of hippocampus.
(5) The Future Forum is a group of 57 health sector specialists chaired by the Professor Steve Field, the former chair of the Royal College of General Practitioners.
(6) The World Humanitarian Summit in May 2016 may be the most timely opportunity to make an honest appraisal of the effectiveness of the current system to deal with the sector’s “ new normal ” of finite resources and unlimited challenges.
(7) This is welcome news but it needs to be borne in mind that the manufacturing sector is still far from racing ahead and serious doubts remain about the strength of demand for manufactured goods over the medium term, particularly once stimulative measures start being withdrawn.
(8) "Medical professionals have perhaps been the least involved [of all sectors] in debates and discussions around abortion, and anti-choice groups have very effectively carried out a deliberate strategy of targeting and influencing health professionals.
(9) The FCx lesions themselves were shown to have no significant effect on DA utilisation in any CP sector.
(10) We present a comparison of the Canadian and American data on expenditures, identifying the sectors in which the experience of the two nations diverges most, and describing the processes of control.
(11) Alton Towers has a long record of safe operation and as we reopen, we are committed to ensuring that the public can again visit us with confidence.” A spokesman for the park said that said that X-Sector, the high-octane section of that park where the Smiler is based, would remain closed until further notice.
(12) And we will sell those assets that can be managed better by the private sector.
(13) "It will mean root-and-branch change for our banks if we are to deliver real change for Britain, if we are to rebuild our economy so it works for working people, and if we are to restore trust in a sector of our economy worth billions of pounds and hundreds of thousands of jobs to our country."
(14) Despite some high profile problems, the private sector share of community services has been expanding; its market share grew around 50% in the two years from 2010-11.
(15) Analysis of a transposable, element-induced o2 allele, o2-m20, revealed that sectors of endosperm cells contained the nuclear-localized O2 protein, indicating excision of the transposable element.
(16) After clinical examination and semen analysis, we studied 4100 patients by scrotal US with sector mechanical (7.5 MHz) probe with water bag and by transrectal US for prostatic vesicular region evaluation with 5-6.5 MHz linear probe (lately we used biplanar probe).
(17) We are going to see a sharp fall unless sellers hold the sector up by making aggressive offers.
(18) Thanks to the groundbreaking technology and heavy investment of a new breed of entertainment retailers offering access services, we are witnessing a revolution in the entertainment industry, benefitting consumers, creators and content owners alike.” ERA acts as a forum for the physical and digital retail sectors of music, and represents over 90% of the of the UK’s entertainment retail market.
(19) Burham's claim to be the continuity candidate, coupled with his past reputation as a Blairite, suggests a centrist leadership that would stay on course in terms of private sector involvement in public services, a crackdown on benefit claimants and a tougher stance on criminals.
(20) Generally, patients with anterior sector conditions showed improved performance with band-pass filters (not with ND filters).