(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Sheave
Definition:
(v.) A wheel having a groove in the rim for a rope to work in, and set in a block, mast, or the like; the wheel of a pulley.
(v. t.) To gather and bind into a sheaf or sheaves; hence, to collect.
Example Sentences:
(1) Ultrastructurally, clusters of intermediate filaments, twisted sheaves of filaments resembling tonofilaments, intermediate junctions, and intracellular canaliculi were found in these cells.
(2) Nineteen years ago I’d collected sheaves of estate agents’ details and piled them into Yes, No, Maybe.
(3) The art critic John Ruskin claimed to have burned sheaves of them in 1858, but 10 years ago an expert at the Tate Gallery came to the conclusion that this never happened.
(4) From the end of the first month to the sixth month small sheaves of smooth-muscle cells were observed in the cicatricial tissue.
(5) When you rush big projects in sensitive places, you increase the potential for a disaster – it regularly leads to massive environmental damage and an expensive clean-up that could have been prevented if there had been detailed scientific consideration and community engagement,” Sheaves said.
(6) Most days at midday, Uber’s nondescript office in London’s King’s Cross opens its doors and dozens of men clutching sheaves of driving licences and insurance documents pour in.
(7) Almost all asbestos fibers detected in the tap water possessed the form of thick or sheaved fibers with lengths ranging from ca.
(8) Still employed in the early 1990s, the classic label sported a blue-and-white striped milk jug beside two cherry-red mugs, resting on sheaves of wheat, against an luminous yellow arc of - well, obviously, an incandescent light bulb.
(9) "If we paint the phases of a riot, the crowd bustling with uplifted fists and the noisy onslaught of the cavalry are translated upon the canvas in sheaves of lines corresponding to the conflicting forces, following the general law of violence of the picture.
(10) Prof Marcus Sheaves, head of marine biology at James Cook University, said the lack of a considered process around the wetlands plan was “a serious concern”.
(11) Sheaves questioned the lack of a plan for “detailed integrated assessment of all components of the proposal and their implications, despite the sensitive nature of location of the proposed dredge-spoil dumping, and the public concern over the proposal”.
(12) Benign prostatic epithelium showed vimentin intermediate filaments distinctively distributed in the basal regions and as paranuclear sheaves along the long axis of the cell.
(13) Sheaves of complexly organized fibrillar components appear in the neuronal perikaryon; and ribosomes, Golgi elements, and microtubules are conspicuously numerous.
(14) Sheaves said coastal wetlands were crucial to the health of the Great Barrier Reef , as they prevented certain sediments and pollutants from flowing onto the coral.
(15) The differentiation of their processes was observed to involve a series of complex events related to retraction of the thick apical processes from the tips of which sheaves of filiform processes emerged, growth in the number and the thickness of the filiform processes, resorption of some of these filiform processes, cyclic changes in the appearance, resorption and reappearance of excrescences on the filiform processes, and changes in size and shape of the growth cones.
(16) Most myofibroblasts contained only sheaves of myofilaments along the margins of the cells, but some cells contained larger bundles of myofilaments and very closely resembled smooth muscle cells.
(17) Crystals may be arranged in sheaves or bundles and pass from one cell to another disrupting the continuity of membranes of both cells and nuclei.
(18) The public probably don’t see it but she has sheaves of handwritten notes.” The historical role of the PAC has been to dig into misspending by Whitehall, such as the tagging scandal that saw G4S and Serco charging for dead offenders (“Shocking complacency”, said Hodge).
(19) Many differentiated tumor cells contained organelles, such as vesicle-crowned lamellae (synaptic ribbons) and microtubular sheaves, as consistent with adult hamster pineocytes.
(20) One of the most famous bonfires in British art history, the destruction in 1858 of sheaves of erotic paintings by JMW Turner, by the horrified critic John Ruskin, never happened.