(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Slit
Definition:
() 3d. pers. sing. pres. of Slide.
(imp. & p. p.) of Slit
(n.) To cut lengthwise; to cut into long pieces or strips; as, to slit iron bars into nail rods; to slit leather into straps.
(n.) To cut or make a long fissure in or upon; as, to slit the ear or the nose.
(n.) To cut; to sever; to divide.
(n.) A long cut; a narrow opening; as, a slit in the ear.
Example Sentences:
(1) There was no evidence for ocular trauma, disease, or vascular malformation by slit-lamp examination and gonioscopy.
(2) In normal kidneys fixed by perfusion with tannic acid and glutaraldehyde, glomerular slit diaphragms have been reported to consist of highly ordered and isoporous substructures with a zipper-like configuration.
(3) Neutral dextran clearances for radii greater than 30 A were elevated during the PEAK period, and, concurrently, there was extensive intraglomerular microthrombosis, obliteration of foot processes, and disruption of filtration slit diaphragms.
(4) Neovascular responses were evaluated by daily slit-lamp observations and terminal whole-mount and histologic examinations of colloidal carbon-perfused vessels.
(5) Only 5 or 6 patients could be examined per hour with the 60D slit-lamp compared with 30-35 examined by reading retinal photographs.
(6) This flap is formed by a triangle-shaped excision combined with cranial and caudal slitting of the periosteum.
(7) Negative slit smears for AFB from the nodules repeatedly and the histology of one on the skin nodules clinched the diagnosis of multicentric reticulohistiocytosis.
(8) Incisional slit grafting utilizes larger numbers of smaller grafts than does traditional punch grafting.
(9) After amputation of the closed tip, a cap from a syringe was inserted via a slit made at the base into one prong of a pair of nasal cannulae.
(10) The use of a standard 35 mm camera with a spot metering system to take slit-lamp photographs is described.
(11) Light scatter from epithelial cells in a slit-scan flow system is modeled using the Fraunhofer condition of scalar diffraction theory.
(12) Depending on the slit width of the illumination source, a typical endothelial photomicrograph contains three or four distinct zones.
(13) By using a slit plate, scanographic arterial studies can be performed with a tomographic attachment of an X-ray unit that is normally used for routine radiographic examinations.
(14) The present study, however, qualitatively evaluates the unsharpness of redundant shadows of the mandibular ramus, especially with reference to the effects of first-slit width.
(15) Microcirculation is clearly visible and can be observed on the conjunctival mucosa by means of any microscope and notably with the slit lamp microscope of ophtalmologists.
(16) The dark, luxury air in the silent bedrooms of empty riverside apartments, their identical curving blocks clustered in threes and fours, grim and silent as gill slits, will be theirs.
(17) For the purpose of covering the demerits of the conventional sliding tube, a new slit sliding tube which is made up of three parts was devised by us.
(18) The optimal slit width in the ordinary roentgenokymographic device was found to equal 0.5+0.03 mm, and in the protected roentgenokymographic device the investigation of adults and children indicated 0.15+0.02 and 0.22+0.02 mm, respectively.
(19) Sequential photomicrographs of RBCs passing through interendothelial slits (IES) in walls of venous sinuses in rat spleen were obtained by video recording in vivo microscopic views.
(20) At both stages and with both dextran fractions the following results were obtained: (a) dextran was retained for up to 3 h (the longest interval studied) in the plasma at high concentration; (b) there was a sharp drop in the concentration of tracer between the inner, looser portions of the basement membrane (lamina rara interna) and its outer denser portions (lamina densa), (c) accumulation of dextran was seen in the mesangial areas with time; and (d) no accumulation of dextran was seen in the slits at any time.