(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Slot
Definition:
(n.) A broad, flat, wooden bar; a slat or sloat.
(n.) A bolt or bar for fastening a door.
(n.) A narrow depression, perforation, or aperture; esp., one for the reception of a piece fitting or sliding in it.
(v. t.) To shut with violence; to slam; as, to slot a door.
(n.) The track of a deer; hence, a track of any kind.
Example Sentences:
(1) • Gone Girl picked for opening slot at New York film festival • We predict how Venice, Toronto and Telluride will split the 2014 world premieres
(2) When Question Time was moved to an earlier 9pm slot in May during the MPs' expenses scandal, a panel including Martin Bell, Ben Bradshaw and William Hague had 3.7 million viewers and a 17% share.
(3) McCall and her ad director, Stuart Taylor, have also managed to offer 'page dominance' to all but the smallest potential advertisers, meaning that big ads will not be diluted down by having smaller slots alongside them.
(4) DNA is isolated from synchronized populations of G1 and S phase cells, it is slot-blotted at the same DNA concentration(s) for each population, and it is hybridized with 32P-labeled DNA probes that are specific to the regions of interest.
(5) The final episode of I Own Britain's Best Home drew 400,000 and 2% for Five in the same time slot.
(6) Experiments were performed to measure velocities in front of six slot hoods.
(7) The issue was first raised by BBC2 controller Janice Hadlow and brought to the attention of the then BBC Vision director Jana Bennett – number two to BBC director general Mark Thompson – after the sitcom, which was planned for a post-9pm watershed slot, was moved to pre-watershed.
(8) Leroy Sané, a substitute, slotted in seamlessly on his debut.
(9) Standard gels, 200 mm wide with 20 sample slots have also been used.
(10) Findley darts round him and slots him beneath the advancing Ricketts.
(11) 27 August, 8pm Will Self The nearest the book festival circuit has to a rock star has three slots.
(12) The gastric factors controlling abundance of mRNA encoding the important neuropeptide, gastrin releasing peptide (GRP) in rat stomach, were examined by Northern and slot blot analysis.
(13) A complete 0.018-inch slot straight-wire appliance was used to align the teeth, close lower spaces, and detail the occlusion.
(14) It seemed that a gust of wind had dislodged part of the screen’s moorings leaving the visiting Leicester party, who had to negotiate a new take-off slot for their post-match flight back to East Midlands, looking unimpressed when they ventured to the touchline.
(15) FISH results on primary tumors were concordant with slot blot results on amplification and with immunohistochemical detection of overexpression.
(16) Eggs of southern corn rootworm (Diabrotica undecimpunctata howardi Barber) were subjected to electromagnetic energy at 2.45 GHz in slotted waveguide applicators to determine ovicidal threshold levels.
(17) When incubated with alpha-32P-labeled ribonucleoside triphosphates in vitro, nuclei isolated from haploid or diploid cells transcribed rRNA, tRNA, and mRNAs in a strand-specific manner, as shown by slot blot hybridization of the in vitro synthesized RNA to cloned genes encoding 5.8S, 18S and 28S rRNAs, tRNATyr, and GAL7, URA3, TY1 and HIS3 mRNAs.
(18) Herein, we describe the procedures for preparation and labeling of DNA probes and the principles that regulate dot, slot and Southern blot hybridization.
(19) It was considerably — and predictably — up on the audience who used to watch Norton in his old 10pm slot on BBC2, when it was typically watched by between 1 million and 1.5 million viewers.
(20) BBC1 slipped to second place in the slot behind a repeat of Martin Clunes drama Doc Martin, with 3.6 million viewers and an 18% share between 9pm and 11pm.