(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Spline
Definition:
(n.) A rectangular piece fitting grooves like key seats in a hub and a shaft, so that while the one may slide endwise on the other, both must revolve together; a feather; also, sometimes, a groove to receive such a rectangular piece.
(n.) A long, flexble piece of wood sometimes used as a ruler.
Example Sentences:
(1) This paper addresses the latter assumption by applying a direct and flexible approach, cubic spline functions, to two widely used models: the logistic regression model for binary responses and the Cox proportional hazards regression model for survival time data.
(2) After filament images were straightened by spline-fitting, several transforms showed well-defined layer-lines arising from the helical structure of the filament.
(3) We have compared three interpolation methods (surface splines, spherical splines and tridimensional interpolation functions).
(4) The smoothing B-spline function was applied to 3, 10, 25, 50, 75, 90, and 97 percentile TW2 RUS, carpal and 20-bone scores.
(5) The four parameter logistic method, which is based on an approximation of the mass action law, performed better than the Spline method, a procedure which makes no a priori assumptions about the data.
(6) The first and second derivatives of progress curves are obtained from the cubic spline function.
(7) To improve the qualitative and quantitative analysis of surfaces of protein, two new methods are proposed: one that smoothes the MS surface of Connolly with B-spline smoothing functions to highlight the significant features of the surface, and one that computes the density of surface neighborhood to allow quantitative comparison.
(8) In the model, patellofemoral joint profiles projected on a horizontal plane have been expressed as spline functions.
(9) It was demonstrated that by using a least-squares surface-fitting technique, the SPG data on the surface can accurately be described by a single parametric biquintic spline function.
(10) Approximating the signal with a linear combination of cubic B-splines with equally spaced knots, according to the linear least-squares criterion gives the desired data reduction and an elegant way to perform an automatic analysis.
(11) The practical implementation of a rapid Catmull-Rom (cardinal) spline is described, and its advantages with respect to speed and ease of use are discussed.
(12) One of these is the procedure known as one of the best automatic smoothing and differentiating techniques: generalised cross validatory spline smoothing and differentiation (GCVC).
(13) Splines, were invented nearly 30 years ago and have been shown to have desirable properties.
(14) The spline technique is superior in accuracy to sampling at eight-times the Nyquist rate and is comparable to a Fourier-transform-based interpolation algorithm.
(15) Lines representing linear regression, log-linear regression or quadratic regression were inferior to those described by linear splines.
(16) Although spline functions are by no means unknown to demographers, no simple and direct explanation of their application exists.
(17) The spline technique was used to analyse these data as continuous variables, and showed that the 'super-obese' group of families was too small to be of any practical importance.
(18) Using penalized likelihood the three curves can be fitted as cubic splines by non-linear regression, and the extent of smoothing required can be expressed in terms of smoothing parameters or equivalent degrees of freedom.
(19) In general, the bilinear and bicubic spline methods of interpolation perform about equally.
(20) The folding pathway is defined by piecewise B-spline curves and the atoms are initially positioned with respect to the local Frenet trihedra determined by the equations of the curves.