(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Striation
Definition:
(n.) The quality or condition of being striated.
(n.) A stria; as, the striations on a shell.
Example Sentences:
(1) We show that over a limited range of high spatial frequencies this noise takes on a striated appearance, with the striations running perpendicular to the true fringe orientation.
(2) Cytoplasmic striations seen by light microscopy and trilamellar inclusions seen by electron microscopy were found in ballooned adrenocortical cells.
(3) In addition the bare central backbone showed transverse striations.
(4) These vacuoles contained one or several typical collagen fibrils and had either an electron-lucent matrix or contained an electron-dense material obscuring the fibrillar outlines and cross-striations.
(5) A new optical-electronic method has been developed to detect striation spacing of single muscle fibers.
(6) Fungiform papillae which had a round depression on the top were distributed sporadically among the filiform papillae, and contained columnar CTC with several plane striations running longitudinally along the lateral surface.
(7) Often juxtaposing sets of striations are not in correct register with respect to one another.
(8) In the Colobinae striations are oriented in a predominantly mesiodistal direction.
(9) Superficial corneal epithelial striations described as fibrillary lines have been documented as a common finding in normal and keratoconic eyes.
(10) A characteristic 67 nm transverse striation produced by the intermixing of tropocollagen and collagen types 1 and 3 is observed.
(11) These masses were classified into three broad categories: centrally necrotic masses with a large predominantly liquefactive center and higher density periphery (29); multilocular, septated masses with distinct linear bands or striations (21); and miscellaneous masses (9).
(12) These transition cells possessed apical granules of variable size as well as prominent basal striations.
(13) Amino acid composition, cross striation banding as observed using electron microscopy, cyanogen bromide peptide patterns in disc electrophoresis gels and resistance of the disulfide regions to pepsin digestion indicated a close similarity to previously described insoluble type III collagen, which was solubilized by limited pepsin digestion.
(14) Rabbits were trained to discriminate between vertical and horizontal striations.
(15) These structures were labelled with a selective antibody and showed regular periodic striation with repeats of approximately 40 nm.
(16) Sometimes, these seemed to be connected with the wall of the intracristal space by fine, electron-dense cross-striations.
(17) In the angiograms, the highly vascular region displays a certain striation which is due to the presence of muscle fiber bundles running between the pathologic vessels.
(18) However, in the clinical setting of acute cholecystitis, the presence of striations suggests gangrenous changes in the gallbladder.
(19) A- and I-band striation positions have been obtained, three-dimensionally reconstructed, and statistically analyzed from the volumes of resting isolated heart cells.
(20) Striation of the cuticle cells was normal, with wearing of their free borders (PL, SEM; fig.