(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Tongue
Definition:
(n.) an organ situated in the floor of the mouth of most vertebrates and connected with the hyoid arch.
(n.) The power of articulate utterance; speech.
(n.) Discourse; fluency of speech or expression.
(n.) Honorable discourse; eulogy.
(n.) A language; the whole sum of words used by a particular nation; as, the English tongue.
(n.) Speech; words or declarations only; -- opposed to thoughts or actions.
(n.) A people having a distinct language.
(n.) The lingual ribbon, or odontophore, of a mollusk.
(n.) The proboscis of a moth or a butterfly.
(n.) The lingua of an insect.
(n.) Any small sole.
(n.) That which is considered as resembing an animal's tongue, in position or form.
(n.) A projection, or slender appendage or fixture; as, the tongue of a buckle, or of a balance.
(n.) A projection on the side, as of a board, which fits into a groove.
(n.) A point, or long, narrow strip of land, projecting from the mainland into a sea or a lake.
(n.) The pole of a vehicle; especially, the pole of an ox cart, to the end of which the oxen are yoked.
(n.) The clapper of a bell.
(n.) A short piece of rope spliced into the upper part of standing backstays, etc.; also. the upper main piece of a mast composed of several pieces.
(n.) Same as Reed, n., 5.
(v. t.) To speak; to utter.
(v. t.) To chide; to scold.
(v. t.) To modulate or modify with the tongue, as notes, in playing the flute and some other wind instruments.
(v. t.) To join means of a tongue and grove; as, to tongue boards together.
(v. i.) To talk; to prate.
(v. i.) To use the tongue in forming the notes, as in playing the flute and some other wind instruments.
Example Sentences:
(1) The stabilized mandible allowed suspension of the tongue.
(2) Patients with cancer of floor of the mouth and oral tongue had higher odds ratios for alcohol drinking than subjects with cancers of other sites.
(3) Pekka Isosomppi Press counsellor, Finnish embassy, London • It may have been said tongue in cheek, but I must correct Michael Booth on one thing – his claim that no one talks about cricket in Denmark .
(4) The concentration dependences of response of frog tongue to D-fructose, D-glucose, and sucrose were almost the same, D-galactose, however, elicited a much larger response in comparison with the other sugars in the whole range of concentrations examined.
(5) A case of osteosarcoma of the tongue is reported, with microscopic findings.
(6) In the QHCl-sucrose condition components separated by the tongue's midline and those spatially mixed produced equal amounts of bitterness suppression.
(7) S. sanguis also adhered to human tongues better than the serum-requiring diphtheroid.
(8) On the basis of these studies, four of the neonates required a tongue-lip adhesion to stabilize the airway.
(9) With the aid of analysis of afferent impulse activity in the cat chorda tympani, it was shown that the effect of application of organic acids solutions of the same pH to the tongue could be represented as follows: propionic acid greater than lactic acid greater than pyruvic acid.
(10) Experimentally induced tongue contact with a variety of solid surfaces during lapping (an activity involving accumulation of a liquid bolus in the valleculae) induced neither increased jaw opening nor the additional EMG pattern.
(11) Application of 1 mM BT (pH 6.3) to the human tongue statistically potentiated the taste of 0.2 M NaCl and 0.2 M LiCl by 33.5% and 12.5% respectively.
(12) The first manifestation was often extranodular (9 patients tonsil, 8 parotid gland, 8 base of tongue, 7 nasopharynx).
(13) The 2014 MTV Video Music Awards didn’t achieve the same degree of controversy as last year’s celebration of tongues, twerking and teddy bears , but between a speech by a homeless teen, an ill-timed wardrobe malfunction, and Beyoncé’s spectacular, epic, show-stopping finale, there were nevertheless a few moments worth watching.
(14) We report the case of an 8-month-old female with an unusual duplication cyst in the anterior two-thirds of the tongue.
(15) It represents the seventh case to occur in the base of tongue and the second to be associated with pregnancy.
(16) CR-ir was also observed in nerve fibers surrounding neuronal cell bodies in autonomic ganglia, and in nerve endings in the lip, tongue, incisal papilla, soft palate, pharynx and epiglottis.
(17) We have examined the keratin proteins in normal human oral mucosa from 6 different regions including hard palate, buccal mucosa, tongue, gingiva and floor of the mouth.
(18) Queen's speech: the day ‘psychoactive drugs’ tripped off the royal tongue Read more The first Queen’s speech of the second term should be golden.
(19) Additional documented organ involvement included liver (two of 10), rectal (three of 10), renal (two of 10), gingiva (two of 10), and tongue (one of 10), although invasive biopsies were not performed in a majority of patients.
(20) Sheet preparations of the stratum granulosum from the epithelium of the ventral surface of mouse tongue permit examination of cell replacement of this maturation compartment of the tissue.