(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Trace
Definition:
(n.) One of two straps, chains, or ropes of a harness, extending from the collar or breastplate to a whiffletree attached to a vehicle or thing to be drawn; a tug.
(v. t.) A mark left by anything passing; a track; a path; a course; a footprint; a vestige; as, the trace of a carriage or sled; the trace of a deer; a sinuous trace.
(v. t.) A very small quantity of an element or compound in a given substance, especially when so small that the amount is not quantitatively determined in an analysis; -- hence, in stating an analysis, often contracted to tr.
(v. t.) A mark, impression, or visible appearance of anything left when the thing itself no longer exists; remains; token; vestige.
(v. t.) The intersection of a plane of projection, or an original plane, with a coordinate plane.
(v. t.) The ground plan of a work or works.
(v. t.) To mark out; to draw or delineate with marks; especially, to copy, as a drawing or engraving, by following the lines and marking them on a sheet superimposed, through which they appear; as, to trace a figure or an outline; a traced drawing.
(v. t.) To follow by some mark that has been left by a person or thing which has preceded; to follow by footsteps, tracks, or tokens.
(v. t.) Hence, to follow the trace or track of.
(v. t.) To copy; to imitate.
(v. t.) To walk over; to pass through; to traverse.
(v. i.) To walk; to go; to travel.
Example Sentences:
(1) Glyceryl p-aminobenzoate and amyl p-dimethyl-aminobenzoate were labeled on 1 and 3 sunscreens, respectively, but glyceryl p-aminobenzoate was not found in any of them and only traces of amyl p-dimethylaminobenzoate were found in 1 sunscreen.
(2) Throughout the entire cultivation cytidyl derivatives occurred in trace quantities.
(3) persisted and was more abnormal in 23% of the cases including specific tracings in 37%.
(4) Traces of the sulphoxide of butylmercapturic acid have been found in rat urine but not in rabbit urine.
(5) No 7 beta-hydroxysteroid dehydrogenase activity and only a trace of 7 alpha-hydroxysteroid dehydrogenase activity could be demonstrated when bile acid was deleted from the growth medium.
(6) Silicon, a relatively unknown trace element in nutritional research, has been uniquely localized in active calcification sites in young bone.
(7) Although various micronutrients (vitamins and trace elements) have also been found to have either a positive or negative association, findings were more clear-cut for the different food items contributing the micronutrients than for the specific micronutrients themselves.
(8) Methods used in tracing and improving cooperation of subjects are described.
(9) Her black persona unravelled this week when Ruthanne and Larry Dolezal, a couple named on her Montana birth certificate as her biological parents, told Spokane’s KREM 2 News that her ancestry was German and Czech, with traces of Native American.
(10) they are shown to inhibit in vitro the release of iron from acidified host cell cytosol, consisting mostly of hemoglobin, a process that could provide this trace element to the parasite.
(11) Thus, the carotid pulse tracing provides an accurate reproduction of the morphology of the pressure tracing recorded from the ascending aorta, and when calibrated by peripheral blood pressure measurement, it can be used to calculate LV pressure throughout ejection.
(12) Mutant C grew anaerobically in the light, whereas mutant G1 was light sensitive and produced only trace amounts of bacteriochlorophyll a (0.6 mumole per ml of protein).
(13) The effect was shown to be due to caldesmon and not to a trace contaminant by its full reversibility after addition of a monospecific caldesmon antibody.
(14) Of 15 organochlorine compounds analyzed, trace amounts mainly of p,p-DDE and polychlorinated biphenyls (PCBs) were detected, but could not be quantitated.
(15) Fifty physiologically characterized units were injected with horseradish peroxidase (HRP) or Lucifer yellow CH (LY) and their processes were traced to the crista.
(16) Polysomnography has revealed that this drug has several interesting qualities that benzodiazepines do not possess: stages 3-4 increase, stage 2 is unchanged or slightly reduced and no abnormal changes are detected on the EEG tracing.
(17) We find that the labelled cell has a myelinated axon, but that the axon loses its myelin within 50 microns of the soma and has not yet been traced further.
(18) He is likely to propose increased funding of plant disease experts, the stepping up of surveillance at ports of entry and a Europe-wide "plant passport" system to trace the origins of all plants coming into Britain.
(19) In addition, the postulated personality for PD may predispose to hard work, perspiration, and increased exposure to putative trace elements in the water supply.
(20) The voltage trace is then analysed with a piece of transparent paper, on which lines corresponding to solutions of the diffusion equation convert the time axis of the voltage trace into a concentration axis.