(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Track
Definition:
(n.) A mark left by something that has passed along; as, the track, or wake, of a ship; the track of a meteor; the track of a sled or a wheel.
(n.) A mark or impression left by the foot, either of man or beast; trace; vestige; footprint.
(n.) The entire lower surface of the foot; -- said of birds, etc.
(n.) A road; a beaten path.
(n.) Course; way; as, the track of a comet.
(n.) A path or course laid out for a race, for exercise, etc.
(n.) The permanent way; the rails.
(n.) A tract or area, as of land.
(v. t.) To follow the tracks or traces of; to pursue by following the marks of the feet; to trace; to trail; as, to track a deer in the snow.
(v. t.) To draw along continuously, as a vessel, by a line, men or animals on shore being the motive power; to tow.
Example Sentences:
(1) Lucy and Ed will combine coverage of hard and breaking news with a commitment to investigative journalism, which their track record so clearly demonstrates”.
(2) DATA Modern football data analysis has its origins in a video-based system that used computer vision algorithms to automatically track players.
(3) The company said it was on track to meet forecasts for annual profit of about £110m.
(4) Liu was a driving force behind the modernisation of China's rail system, a project that included building 10,000 miles of high-speed rail track by 2020 – with a budget of £170bn, one of the most expensive engineering feats in recent history.
(5) Tracks were almost exclusively written on tour, including this jolting number, with an additional four tracks recorded in the studio.
(6) Both microcomputer use and tracking patient care experience are technical skills similar to learning any medical procedure with which physicians are already familiar.
(7) Nevertheless, Richard Bacon MP, a member of the Public Accounts Committee, who has tirelessly tracked failings in NHS IT, said last night: "I think the chances that Lorenzo will be turned into a credible and popular product are vanishingly small.
(8) Gerhard Schröder , Merkel’s immediate predecessor, had pushed through parliament a radical reform agenda to get the country’s spluttering economy back on track.
(9) That would be the first step towards banning Russia’s track team from next year’s Olympics in Rio de Janeiro.
(10) Piedmont’s research, which was conducted among 3,000 filmgoers and weighted to the demographics of the cinemagoing public, is not the same as the Hollywood tracking system, which delivers predictions of box-office success.
(11) Only two of the 31 commandos escaped; the rest were tracked down and killed.
(12) Latencies were increased two- to threefold, and tracking was more variable.
(13) However, clemastine caused a decay in subjects' performance in both Experiments I and II, but only on the tracking task.
(14) Burns has a successful track record of opposing fees.
(15) The workforce has changed dramatically since 1900 – just 29,000 Americans today work in fishing and the number of job titles tracked by the Bureau of Labor Statistics has grown to almost 600 – everything from “animal trainers” to “wind turbine service technicians” (and there are even more sub categories).
(16) The fact that we’re tracking towards the hottest year on record should send chills through anyone who says they care about climate change – especially negotiators at the UN climate talks here in Lima,” said Samantha Smith, who heads WWF’s climate and energy initiative.
(17) Facebook Twitter Pinterest Beyoncé’s last album was an iTunes exclusive, with videos for every track.
(18) Cameras have been set up by the zoo to track his movements and footpaths in the area closed by the county council.
(19) Comparison of these tracks and the Hadar hominid foot fossils by Tuttle has led him to conclude that Australopithecus afarensis did not make the Tanzanian prints and that a more derived form of hominid is therefore indicated at Laetoli.
(20) A lot is being expected of rookie cornerbacks Desmond Trufant and Robert Alford, but defensive co-ordinator Mike Nolan has a good track record of keeping his units competitive.