(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Tread
Definition:
(v. i.) To set the foot; to step.
(v. i.) To walk or go; especially, to walk with a stately or a cautious step.
(v. i.) To copulate; said of birds, esp. the males.
(v. t.) To step or walk on.
(v. t.) To beat or press with the feet; as, to tread a path; to tread land when too light; a well-trodden path.
(v. t.) To go through or accomplish by walking, dancing, or the like.
(v. t.) To crush under the foot; to trample in contempt or hatred; to subdue.
(v. t.) To copulate with; to feather; to cover; -- said of the male bird.
(n.) A step or stepping; pressure with the foot; a footstep; as, a nimble tread; a cautious tread.
(n.) Manner or style of stepping; action; gait; as, the horse has a good tread.
(n.) Way; track; path.
(n.) The act of copulation in birds.
(n.) The upper horizontal part of a step, on which the foot is placed.
(n.) The top of the banquette, on which soldiers stand to fire over the parapet.
(n.) The part of a wheel that bears upon the road or rail.
(n.) The part of a rail upon which car wheels bear.
(n.) The chalaza of a bird's egg; the treadle.
(n.) A bruise or abrasion produced on the foot or ankle of a horse that interferes. See Interfere, 3.
Example Sentences:
(1) Will it continue treading water, deciding cases in pretty much the same way as the law lords used to do - although using blunter language?
(2) He has to tread some of the same path as Joe Biden but without the posturing and aggression.
(3) I'm not in the least ambitious, never have been, and I don't tread on people.
(4) Dombey treads proudly towards his doom with the author's unheard warnings ringing in his ears.
(5) Admittedly, there has been a bit of sour grapes in the English response to the success of Dempsey et al, and no doubt we will be treading those grapes into wine and drinking ourselves into oblivion if Team USA get much further – they are, as today's typically excitable NY Daily News front page informs us, now just "four wins from glory" .
(6) Kristen Woolf, girl-centred practice and strategy director, The Girl Hub , London, UK, @girleffect Don't lose focus on girls: Very clearly men and boys have got to be a central component of the solution, but we need to tread carefully here not to lose the focus on equality and empowerment for girls and women.
(7) Incongruous and illusory depth cues, arising from 'interference patterns' produced by overlapping linear grids at the edges of escalator treads, may contribute to the disorientation experienced by some escalator users, which in turn may contribute to the causes of some of the many escalator accidents which occur.
(8) This assignment to Cairo had been relatively routine - an opportunity to get to know Egyptian politics a little better; but with only three weeks on the ground, hardly time to do anything other than tread water.
(9) UK schools are treading water when we know that matching the very best could boost the growth rate by one percentage point every year.
(10) A noninvasive criterion of occlusions of the lower limb arteries was elaborated from the results of transcutaneous measurement of oxygen tension (TmO2) during treading on a treadmill.
(11) 1982) suggested to require DA (head weaving, reciprocal forepaw treading).
(12) But the oxygen saturations on swimming were in all patients higher than after tread-wheel exercise.
(13) The changes at CDC, which is supposed to invest where other investors fear to tread, follow criticism of the organisation for focusing too much on profits and not enough on development.
(14) Now he’s remarried, with a young, new family, and treading the boards on Broadway.
(15) These figures illustrate how millions of people are treading water, struggling to keep afloat and afford the very basics.
(16) It was only when I was criticized for writing science fiction that I realized I was treading on sacred ground."
(17) That line is trickier to tread for working-class comics, into which category Bishop – with a Liverpool accent so rich it's got calories – falls.
(18) We tread a fine line and, because each picture is judged on its merits on the day, it is very difficult to have hard and fast rules.
(19) Where German officials have feared to tread, dramatists have rushed in.
(20) That doesn’t mean no one should ever criticise Israel, for fear of treading on Jewish sensitivities.