(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Trench
Definition:
(v. t.) To cut; to form or shape by cutting; to make by incision, hewing, or the like.
(v. t.) To fortify by cutting a ditch, and raising a rampart or breastwork with the earth thrown out of the ditch; to intrench.
(v. t.) To cut furrows or ditches in; as, to trench land for the purpose of draining it.
(v. t.) To dig or cultivate very deeply, usually by digging parallel contiguous trenches in succession, filling each from the next; as, to trench a garden for certain crops.
(v. i.) To encroach; to intrench.
(v. i.) To have direction; to aim or tend.
(v. t.) A long, narrow cut in the earth; a ditch; as, a trench for draining land.
(v. t.) An alley; a narrow path or walk cut through woods, shrubbery, or the like.
(v. t.) An excavation made during a siege, for the purpose of covering the troops as they advance toward the besieged place. The term includes the parallels and the approaches.
Example Sentences:
(1) Its boot always held a bivouac bag, a trenching tool of some sort and a towel and trunks, in case he passed somewhere interesting to sleep, dig, or swim.
(2) The RSC’s Erica Whyman stages a story inspired by a local man, the Royal Warwickshire Regiment’s Captain Bruce Bairnsfather, who was known as the cartoonist of the trenches and survived the war to work at the original Shakespeare Memorial theatre.
(3) Stephen Fisher, one of the archaeologists recording the site, says digging the trenches would also have been training for the men, who would soon have to do it for real, and the little slit trenches scattered across the site, just big enough for one man to cower in, might represent their first efforts.
(4) Upon segregation of the conidium from the phialide cell by conidial wall formation, 'trench-like' invaginations gradually appeared in the plasma membrane and a disorganized rodlet pattern was formed on the outer surface of the maturing conidial wall.
(5) The field was taped off while a mechanical digger clawed at the ground, making parallel trenches in the sandy earth.
(6) Scores of archaeologists working in a waterlogged trench through the wettest summer and coldest winter in living memory have recovered more than 10,000 objects from Roman London , including writing tablets, amber, a well with ritual deposits of pewter, coins and cow skulls, thousands of pieces of pottery, a unique piece of padded and stitched leather – and the largest collection of lucky charms in the shape of phalluses ever found on a single site.
(7) He sees HS2 as a "huge trench across the country where we can learn an awful lot about new sites.
(8) But his attitude gradually hardened, particularly after he reached the trenches.
(9) "It looks solid," said Jean Pascal Zanders, a Belgian expert who runs a blog on chemical weapons called The Trench .
(10) What they learn can be summed up in one word: trenches.
(11) The archaeologists had to wear slippers to preserve the site which, at the bottom of a two-metre trench, picked up much damp.
(12) A variety of cold exposure injuries were discussed, including frostnip, chilblains, trench foot, frostbite, and hypothermia.
(13) Alan Trench, an academic specialising in devolution and adviser to expert government commissions, said: "It's clear that Labour voters generally have concerns about how things are at the moment.
(14) But if trapped deep inside wreckage or an underwater trench, the effectiveness can be hindered.
(15) French troops wearing an early form of gas mask in the trenches during the second Battle of Ypres in 1915.
(16) Keeping within the string lines of your footprint, dig a trench about 15cm deep and lay the foundation stones flat and level.
(17) But according to Wayne Cocroft, an English Heritage expert on wartime archaeology, although 20 other trench training sites have been recorded across Britain, many have been damaged by later development, and both the scale and the state of preservation of the Gosport complex is exceptional.
(18) Working in a location to the southeast of Kathmandu, Paul Tapponnier, an earth scientist at the Earth Observatory of Singapore , and his team dug trenches across the fault and used charcoal to date when it had moved.
(19) There are no trenches, barbed wire fences or tank traps.
(20) Accessory glandular tissues were atrophied and debris filled the trenches of the papillae.