(n.) A furrow, channel, or long hollow, such as may be formed by cutting, molding, grinding, the wearing force of flowing water, or constant travel; a depressed way; a worn path; a rut.
(n.) Hence: The habitual course of life, work, or affairs; fixed routine.
(n.) A shaft or excavation.
(v. t.) To cut a groove or channel in; to form into channels or grooves; to furrow.
Example Sentences:
(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Tyre
Definition:
() Curdled milk.
(n. & v.) Attire. See 2d and 3d Tire.
(v. i.) To prey. See 4th Tire.
Example Sentences:
(1) Aedes aegypti and Toxorhynchites splendens were found only in discarded tyres.
(2) Protesters set fire to rubbish bins and tyres, creating pillars of black smoke among the apartment blocks and office buildings in central Tehran.
(3) Called a truck stand, it involves balancing on the front tyre with your hands in the air.
(4) Many leapt from the tyres they were swinging in to furrow their brows and howl in anger.
(5) When four leather strips were tied to the back tyre of the bicycle before laying the track, the one dog tested took the correct direction significantly more often than predicted by random choice.
(6) Amsterdam Uber drivers have been blocked in by taxi drivers and one reported having his tyres slashed.
(7) Within a month of his appointment, he had brokered a "four-figure" deal with local firm Kettering Tyres, and in a SL game against Bath City on January 24 1976, Kettering became the first British club to run out with a company's name emblazoned on their shirts.
(8) Switching to the faster soft tyre for runs in FP2, Hamilton again comfortably had the edge by 0.443sec over Ferrari’s Kimi Raikkonen.
(9) The heat is getting oppressive but we stay alert and try to move with the flow, sticking to the left as much as possible and keeping an eye out for potholes and drain covers whose grilles face the direction of travel – lying in wait to trap unwary bike tyres.
(10) They reportedly threw rocks and paint at the car before smashing a window and slashing one of its tyres.
(11) When her car broke down, she ended up out of work with other labourers on a pea-picking farm, selling her tyres to buy food.
(12) The Formula One tyre manufacturer, Pirelli, expressed concerns at the decision and has warned that any decrease in viewing figures would lead to difficulties.
(13) The group's senior UK executives have privately told MPs in the West Midlands for months that the pound's fluctuations were undermining a plant that has exported more than 300m tyres since it opened in 1927.
(14) In Brisbane during October 1988 one larva of the exotic dengue vector Aedes albopictus (Skuse) was collected by quarantine officers from a consignment of used vehicle tyres imported from Asia.
(15) "I was getting cards saying 'I hope you die in an ambulance on the way to hospital now you have closed this one… ' I had my car tyres slashed, 'Bitch' written on my windows, and 'Shut your effing mouth'."
(16) The eight Goodyear tyre factory workers held two managers hostage in a meeting room for 30 hours in a high-profile “bossnapping” incident in the northern town of Amiens in 2014.
(17) Vettel was fourth on the timesheet, 1.120sec down, with Rosberg fifth after making a mistake on his fast lap on the soft tyres.
(18) Emma Sheppard, with an accomplice, brought three police cars to a juddering halt on New Year’s Eve 2014 in Bristol by puncturing their tyres with the crude device made of plywood and nails.
(19) He singled out measures taken against China’s steel, solar panel, ceramics and tyre industries.
(20) They tied up Badus and Amisi's wife, put them inside a tyre and burned them alive.