(1) The ligands bind at discrete sites in the minor groove of DNA, and analysis on DNA sequencing gels show pronounced protection at the ligand binding sites, as well as more generalized protection.
(2) Recent reports have indicated the usefulness of nuclear grooves (clefts or notches) as an additional criterion for the diagnosis of papillary thyroid carcinoma in fine needle aspirates; most of these studies were carried out on alcohol-fixed material stained with the Papanicolaou stain or with hematoxylin and eosin, which yield good nuclear details.
(3) Intermolecular contacts occur in both oligomers in the minor groove: in the B form through twisted guanine-guanine hydrogen bonding, and in the Z form through base-base stacking and the water network.
(4) The nogalose and aminoglucose sugars lie in the minor and major grooves, respectively, of the distorted B-DNA double helix.
(5) The AFB1 moiety is face-stacked in the major groove with its long axis approximately perpendicular to the helix axis.
(6) These results strongly indicate that metallobleomycin binds in the minor groove of B-DNA and that the 2-amino group of guanine adjacent to the 5' side of the cleaved pyrimidine base is one key element of the specific 5' G-C or G-T recognition by the bleomycin-metal complex.
(7) As a basis for the discussion a possible structure for the DNA complex of the phenylated neutral red is considered in which the extra phenyl ring at N-5 of the phenazinium system, protrudes into the large groove of the DNA helix while the tricyclic part of the ligand is inserted between the DNA base-pairs.
(8) A high intensity of the reactions was observed in certain cells of the neural groove in 24-hours' embryos and in the neural tube of 48-hours' embryos.
(9) Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured.
(10) In the absence of boxes or grooves, pins markedly enhanced both retention and resistance.
(11) Therefore in artificial knee replacement a lateral tilt of the patella sliding groove should not be propagated as 'physiological'.
(12) Many antitumor drugs, and many carcinogens, act by binding within the minor groove of double-helical DNA, interfering with both replication and transcription.
(13) This instrument, a modification of a corneal trephine, provides a neat, smooth groove of adjustable depth.
(14) and the fluid ejected from the ejaculatory groove region (about 0.2 ml.).
(15) 3) The significance of minor groove Mtase-DNA interactions to specificity is confirmed.
(16) (v) The bis-benzimidazole drug Hoechst-33258, which binds in the minor groove of B-DNA, exhibits very little fluorescence in the presence of the ps hairpins but a normal, enhanced emission with the aps oligonucleotides.
(17) We have studied the time-resolved and the steady-state fluorescence of the DNA groove binders 4',6-diamidino-2-phenylindole (DAPI) and Hoechst 33258 with the double stranded DNAs poly(dA-dU) and poly(dI-dC) and their halogenated analogs, poly(dA-I5dU) and poly(dI-Br5dC).
(18) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(19) All cases had true hypertelorism and a median nasal groove with absence of the nasal tip.
(20) Distamycin, Hoechst 33258, and DAPI were used as agents capable of AT-specific binding in the minor groove of DNA while producing no profound long-range distortion of DNA structure.
Gully
Definition:
(n.) A large knife.
(n.) A channel or hollow worn in the earth by a current of water; a short deep portion of a torrent's bed when dry.
(n.) A grooved iron rail or tram plate.
(v. t.) To wear into a gully or into gullies.
(v. i.) To flow noisily.
Example Sentences:
(1) Some fields had lightly furrowed brows, others deep gullies and humpbacked hills.
(2) From the third ball, though, he makes good his escape with a thick edge through the gully region for a single.
(3) Transporting heavy building materials across dirt streets riven with gullies and piled high with detritus is not easy, and theft of building materials is commonplace in Kibera.
(4) Nearly a decade ago, Nasa’s Mars Global Surveyor took pictures of what appeared to be water bursting through a gully wall and flowing around boulders and other rocky debris.
(5) Last week, the search turned to a gully near a rubbish dump in the neighbouring city of Cocula, but still no remains have been identified.
(6) Andy Wilson (@andywiz) England on course to bowl 14 or even 15 overs in the first hour June 20, 2014 11.38am BST 9th over: Sri Lanka 24-0 (Karunaratne 10, Silva 10) Karunaratne picks up four more with the squirtiest of squirty drives that zips away through gully.
(7) Accessible only on foot, the Needles section of the Canyonlands national park has pink and creamy turrets, chimneys, gullies, mysterious canyons and weird formations.
(8) They show people in white jump suits working at the bottom of the gully reportedly about 10m deep and reachable only with the help of ropes.
(9) Pools of ticks, Ixodes (Ceratixodes) uriae collected between 1975 and 1979 at Macquarie Island, yielded 33 strains of at least 4 different viruses: Nugget virus (Kemerovo group), 1 strain; Taggert virus (Sakhalin group) 9 strains; a previously undescribed flavivirus, related to Central European Tickborne encephalitis virus, for which the name "Gadgets Gully" is proposed, 9 strains; a virus serologically related to the Uukuniemi serogroup, family Bunyaviridae, for which the name "Precarious Point" is proposed, 10 strains.
(10) Facebook Twitter Pinterest Sheep graze next to a dried-out gully usually flowing with spring water, in the Palestinian village of al-Auja, near Jericho.
(11) The St. Agnes Community Health Centre was established in October 1974, in the rapidly growing area of Tea Tree Gully, South Australia.
(12) Updated at 11.33am BST 11.22am BST 32nd over: England 68-5 (Root 7, Ali 10) Moeen sees a wide one, and, keen to attack, cuts hard and high past gully for four.
(13) In the western city of Lanzhou, officially deemed by the World Health Organisation to have the worst air in China , officials have proposed digging great gullies into the surrounding mountains in the hope of trapping polluted air in a gigantic landscape gutter, like an atmospheric ha-ha.
(14) Broad's not bowled well today, but he tempts Sangakkara with slight width - and Sangakkara flashes, toe-ending to gully, where Bell dives low and left to snaffle an excellent catch.
(15) VVS Laxman played an injudicious shot off Lonwabo Tsotsobe, edging to gully, before Suresh Raina offered catching practice to Harris at first slip.
(16) The search for 43 student teachers who went missing in Mexico a month ago is now focusing on a gully on the edge of a municipal rubbish dump.
(17) The pier is plenty deep for diving, with access to a narrow gully beneath the drawbridge and a pristine, horse-shoe beach on the opposite side of the fort.
(18) Antibodies to a potentially harmful flavivirus, Gadget's Gully virus, were equally present (4%) in both avian and human sera.
(19) Around noon every day, automated pumps just above the pond are switched on and for the next few hours 400,000 gallons (1.8m litres) of water are sent cascading down a brick-lined gully into the lake.
(20) It was also a place of sandy gullies formed by sporadic streams in the rainy season, where nomads brought their camels.