(n.) An instrument for driving nails, beating metals, and the like, consisting of a head, usually of steel or iron, fixed crosswise to a handle.
(n.) Something which in firm or action resembles the common hammer
(n.) That part of a clock which strikes upon the bell to indicate the hour.
(n.) The padded mallet of a piano, which strikes the wires, to produce the tones.
(n.) The malleus.
(n.) That part of a gunlock which strikes the percussion cap, or firing pin; the cock; formerly, however, a piece of steel covering the pan of a flintlock musket and struck by the flint of the cock to ignite the priming.
(n.) Also, a person of thing that smites or shatters; as, St. Augustine was the hammer of heresies.
(v. t.) To beat with a hammer; to beat with heavy blows; as, to hammer iron.
(v. t.) To form or forge with a hammer; to shape by beating.
(v. t.) To form in the mind; to shape by hard intellectual labor; -- usually with out.
(v. i.) To be busy forming anything; to labor hard as if shaping something with a hammer.
(v. i.) To strike repeated blows, literally or figuratively.
Example Sentences:
(1) Meeting after meeting during 2011 to try to hammer out agreements about the basic shape of the Egyptian constitution – meetings that always mysteriously collapsed.
(2) The result will be yet another humiliating hammering for Labour in a seat it could never win, but hey, never mind.
(3) The trust was a compromise hammered out in the wake of the Hutton report, when the corporation hoped to maintain the status quo by preserving the old BBC governors.
(4) Denni Karlsson and I are standing by a glacial river as it hammers through a rocky gorge.
(5) The preceding paper (Hammer, C.H., A. Nicholson, and M. M. Mayer, 1975, Proc.
(6) The neurological deficits presented in this case were due to pontine infarction, which was suspected to be produced by thrombosis from the aneurysm, and a hydrocephalus might have been caused by a "water-hammering" effect of the elongated basilar artery.
(7) You’d think Michael Foot himself was running, attending debates in a hammer and sickle-print donkey jacket, from the amount we’ve been talking about him.
(8) The ultrasonic root planing however showed a more discrete scalloped surface with very small tears and having a hammered appearance.
(9) It's hard to imagine a more masculine character than Thor, who is based on the god of thunder of Norse myth: he's the strapping, hammer-wielding son of Odin who, more often than not, sports a beard and likes nothing better than smacking frost giants.
(10) He's scored for the Hammers, Newcastle, Derby and Leicester.
(11) IPC Media's NME, which was overtaken by Future Publishing monthly Metal Hammer for the first time in the second half of last year, had an average weekly circulation of 40,948 in the first half of 2009, down 27.2% on the same period in 2008.
(12) On the weather map rain hammers down like a monsoon.
(13) Formative experiences included watching Hammer horror films aged six as his babysitter passed him cigarettes, and of course Top Of The Pops: "I remember being seven and watching Ian Dury & The Blockheads and Lena Lovich.
(14) In 1967 Baker's career took a different turn when he joined Hammer.
(15) However, the match would end 2-2 thanks to a last-gasp Leonardo Ulloa penalty awarded after Jeffrey Schlupp went down under pressure from Carroll – something which infuriated the Hammers striker.
(16) Fabregas hammers it down the middle, the ball sailing slightly to the left before bulging the net.
(17) Global stock markets have fallen sharply on fears that the proposed €110bn (£95bn) rescue package hammered out over the weekend for Greece will not be enough to solve its financial crisis, as well as concern that the problems could spread to other European countries.
(18) Work to hammer out the details would begin immediately, Ghani said on Friday.
(19) He urged the prime minister, David Cameron, and Osborne to join leaders in Brussels to hammer out a deal.
(20) The relationship between final hammer velocity and maximum amplitude of radiated piano sound was investigated.
Hammerhead
Definition:
(n.) A shark of the genus Sphyrna or Zygaena, having the eyes set on projections from the sides of the head, which gives it a hammer shape. The Sphyrna zygaena is found in the North Atlantic. Called also hammer fish, and balance fish.
(n.) A fresh-water fish; the stone-roller.
(n.) An African fruit bat (Hypsignathus monstrosus); -- so called from its large blunt nozzle.
Example Sentences:
(1) Six additional divalent ions were tested for their ability to support hammerhead cleavage.
(2) However, a segment of approximately one-third of the PLMVd sequence has the elements required to form in the RNAs of both polarities the hammerhead structures proposed to act in the in vitro self-cleavage of avocado sunblotch viroid (ASBVd) and some satellite RNAs.
(3) When injected into the nucleus of frog oocytes, the ribozyme tRNA gene (ribtDNA) produces 'hammerhead' ribozymes which cleave the 5' sequences of U7snRNA, its target substrate, with high efficiency in vitro.
(4) All combinations of mutant substrate and mutant ribozyme were less active than the corresponding single mutations, suggesting that the hammerhead contains few, if any, replaceable tertiary interactions as are found in tRNA.
(5) Nine different hammerhead RNA self-cleaving domains consistent with the consensus secondary structure proposed by Keese and Symons (1987) were prepared and tested for cleavage.
(6) To investigate the binding properties of Mg2+ to the hammerhead ribozyme, cleavage rates and CD spectra for substrates containing inosine or guanosine at the cleavage site were measured.
(7) The hammerhead domains consist of a 34 nucleotide ribozyme bound to a complementary 13 nucleotide non-cleavable DNA substrate.
(8) Also, inversion of configuration at phosphorus is confirmed for a two-stranded hammerhead.
(9) Based on comparisons with self-cleaving plant viral satellite RNAs, hammerhead-shaped active structures, each containing one self-cleavage site, were proposed for the plus and minus ASBV RNAs and the newt RNA, but the stability of these hammerheads has been questioned.
(10) Here, we show that the purified full-length dimeric plus RNA, when incubated under our standard self-cleavage conditions, also self-cleaved by a double-hammerhead structure.
(11) The hammerhead ribozyme, as engineered by J. Haseloff and W. L. Gerlach [(1988) Nature (London) 334, 585-591], is an RNA molecule containing two regions of conserved nucleotides, a double helix, called helix II, which connects the two conserved regions, and flanking arms of variable sequence, which hybridize the ribozyme to its specific target.
(12) Insertion, deletion and base substitution mutations were carried out on a 58 base RNA containing the sequence of the single-hammerhead structure of the plus RNA of the virusoid of lucerne transient streak virus, and the effects on self-cleavage assessed.
(13) Analysis of the cleavage products of several of these hammerhead analogues confirms the involvement in the reaction of the 2'-OH adjacent to the cleavage site in the substrate, and demonstrates that some 2'-OH groups in the catalytic region strongly affect activity.
(14) The oligoribonucleotides were used as substrates in the study of the mechanism of cleavage of an RNA hammerhead domain having the phosphorothioate group at the cleavage site.
(15) These catalytic RNAs, or ribozymes, form a stem-loop secondary structure called a 'hammerhead' in which the catalytic (ribozyme) and substrate sequences are brought close together.
(16) Two sequence variants contained nucleotide changes in the double hammerhead-like self-cleaving structure identified in ASBV RNA.
(17) We have designed a hammerhead-type RNA system which consists of three RNA fragments for normal and modified complexes which contain a non-cleavable substrate with 2'-O-methylcytidine and a guanosine-to-inosine replaced enzyme.
(18) Although related to the hammerhead structure, sequences flanking the plus strand termini showed differences from the consensus and may be folded into a different structure containing a pseudo-knot.
(19) We have constructed and characterised in vitro a number of hammerhead ribozymes designed to cleave individual RNAs encoded by these genes.
(20) Substitutions of DNA for RNA in the various stems of a hammerhead ribozyme have been analyzed in vitro for kinetic efficiency.