What's the difference between hard and pard?

Hard


Definition:

  • (superl.) Not easily penetrated, cut, or separated into parts; not yielding to pressure; firm; solid; compact; -- applied to material bodies, and opposed to soft; as, hard wood; hard flesh; a hard apple.
  • (superl.) Difficult, mentally or judicially; not easily apprehended, decided, or resolved; as a hard problem.
  • (superl.) Difficult to accomplish; full of obstacles; laborious; fatiguing; arduous; as, a hard task; a disease hard to cure.
  • (superl.) Difficult to resist or control; powerful.
  • (superl.) Difficult to bear or endure; not easy to put up with or consent to; hence, severe; rigorous; oppressive; distressing; unjust; grasping; as, a hard lot; hard times; hard fare; a hard winter; hard conditions or terms.
  • (superl.) Difficult to please or influence; stern; unyielding; obdurate; unsympathetic; unfeeling; cruel; as, a hard master; a hard heart; hard words; a hard character.
  • (superl.) Not easy or agreeable to the taste; stiff; rigid; ungraceful; repelling; as, a hard style.
  • (superl.) Rough; acid; sour, as liquors; as, hard cider.
  • (superl.) Abrupt or explosive in utterance; not aspirated, sibilated, or pronounced with a gradual change of the organs from one position to another; -- said of certain consonants, as c in came, and g in go, as distinguished from the same letters in center, general, etc.
  • (superl.) Wanting softness or smoothness of utterance; harsh; as, a hard tone.
  • (superl.) Rigid in the drawing or distribution of the figures; formal; lacking grace of composition.
  • (superl.) Having disagreeable and abrupt contrasts in the coloring or light and shade.
  • (adv.) With pressure; with urgency; hence, diligently; earnestly.
  • (adv.) With difficulty; as, the vehicle moves hard.
  • (adv.) Uneasily; vexatiously; slowly.
  • (adv.) So as to raise difficulties.
  • (adv.) With tension or strain of the powers; violently; with force; tempestuously; vehemently; vigorously; energetically; as, to press, to blow, to rain hard; hence, rapidly; as, to run hard.
  • (adv.) Close or near.
  • (v. t.) To harden; to make hard.
  • (n.) A ford or passage across a river or swamp.

Example Sentences:

  • (1) Lucy and Ed will combine coverage of hard and breaking news with a commitment to investigative journalism, which their track record so clearly demonstrates”.
  • (2) Sierra Leone is one of the three West Africa nations hit hard by an Ebola epidemic this year.
  • (3) Topical and systemic antibiotic therapy is common in dermatology, yet it is hard to find a rationale for a particular route in some diseases.
  • (4) Given Australia’s number one position as the worst carbon emitter per capita among major western nations it seems hardly surprising that islanders from Fiji, Samoa, Vanuatu and other small island developing states have been turning to Australia with growing exasperation demanding the country demonstrate an appropriate response and responsibility.
  • (5) They had learned through hard experience what Frederick Douglass once taught -- that freedom is not given, it must be won, through struggle and discipline, persistence and faith.
  • (6) In 60 rhesus monkeys with experimental renovascular malignant arterial hypertension (25 one-kidney and 35 two-kidney model animals), we studied the so-called 'hard exudates' or white retinal deposits in detail (by ophthalmoscopy, and stereoscopic color fundus photography and fluorescein fundus angiography, on long-term follow-up).
  • (7) It is a moment to be grateful for what remains of Labour's hard left: an amendment to scrap the cap was at least tabled by John McDonnell and Jeremy Corbyn but stood no chance.
  • (8) She stopped working only when the pain made it hard for her to get to work.
  • (9) He was reclusive, I know that, and he was often given a hard time for it.
  • (10) This defeat, though, is hardly a good calling card for the main job.
  • (11) Since this test is easily performed and hardly stresses the patient, it should routinely be the initial one for the diagnosis of renal osteopathy.
  • (12) Never become so enamored of your own smarts that you stop signing up for life’s hard classes.
  • (13) But I don't wish to be too hard on the judge for not taking that view.
  • (14) Our campaign has been going for some time and each step in our progress has been hard won, by campaigners paid and volunteer alike.
  • (15) I am rooting hard for you.” Ronald Reagan simply told his former vice-president Bush: “Don’t let the turkeys get you down.” By 10.30am Michelle Obama and Melania Trump will join the outgoing and incoming presidents in a presidential limousine to drive to the Capitol.
  • (16) All the same, it's hard to approach the school, which charges nearly £28,000 for boarders and nearly £19,000 for day girls and is sometimes called "the girls' Eton", without a few prejudices.
  • (17) Governmental officials as well as medical scientists in Taiwan have worked hard in recent years to develop and to implement various measures, such as prenatal diagnosis and neonatal screening, to lower the incidence of hereditary diseases and mental retardation in the population.
  • (18) Cooper, who was briefly a social worker in Los Angeles, also suggests working hard to build a rapport with colleagues in hotdesking situations.
  • (19) Critics of wind power peddle the same old myths about investment in new energy sources adding to families' fuel bills , preferring to pick a fight with people concerned about the environment, than stand up to vested interests in the energy industry, for the hard-pressed families and pensioners being ripped off by the energy giants.
  • (20) The spirit is great here, the players work very hard, we kept the belief when we were in third place and now we are here.

Pard


Definition:

  • (n.) A leopard; a panther.

Example Sentences:

  • (1) Comparison of wild type and the mutant parD promoter sequences indicated that three short repeats are likely involved in the negative regulation of this promoter.
  • (2) In contrast to CcdB, the Kid protein of the ParD system induces RecA-dependent cleavage of the cI repressor of bacteriophage lambda very inefficiently or not at all.
  • (3) The rate of admissions to psychiatric hospitals of patients with primary alcohol-related diagnoses (PARD) has increased from 1971 to 1983 and they now account for 19.7% of all admissions.
  • (4) Since the parDE operon requires the presence of the parCBA operon for efficient stabilization under certain growth conditions, the potential role of multimer resolution in plasmid stabilization was tested by substituting the ColE1 cer site for the parCBA operon.
  • (5) The system, which we have called ParD, maps inside the 1.45-kb PstI-EcoRI fragment that is adjacent to the origin of replication of the plasmid.
  • (6) And then I read another article recently that I am coming and watch over your shoulder Pards.
  • (7) Both of these promoters are repressed by their own gene products in the same manner in all three bacteria tested, with ParA functioning as the primary repressor of p-parCBA and ParD functioning as the repressor of p-parD.
  • (8) The ParD protein appears to bind to one inverted repeat sequence, located between the -35 and -10 boxes of p-parD.
  • (9) In vitro mutagenesis with hydroxylamine of a ParD- miniderivative of R1, pAB174, yielded mutants that were less stable in the cell than pAB174.
  • (10) The deletion analysis further allowed a redefinition of the minimal functional region as 790 bp in length, consisting of the parD gene (243 bp) and its promoter as well as sequences downstream of parD.
  • (11) When I speak with Pards tomorrow he may see some other position that he wants to look better of or get a better player for that area.
  • (12) Determination of the 5' ends of ParD transcripts, revealed that the genes coding for these proteins are transcribed from a single promoter.
  • (13) While the cer site did function to resolve plasmid multimers, it was not sufficient to restore stabilization activity to the parDE operon under growth conditions that require the parCBA operon for plasmid stability.
  • (14) The phenotype of a recently-described mutant (OV6), conditionally defective in chromosome partitioning and septal positioning, was originally thought to be due to a new gene (parD) mapping at 88.4 min.
  • (15) Transcriptional fusions were used to show that parA, parB, and parC are combined in an operon, while parD constitutes a separate transcription unit.
  • (16) The stability determined by the systems ParD of plasmid R1 and Ccd of plasmid F is due to the concerted action of two proteins, a cytotoxin and an antagonist of this function.
  • (17) In this paper we report that CcdA and Kis proteins, the antagonists of the Ccd and ParD systems respectively, share significant sequence homologies at both ends.
  • (18) The proteins P10 and P12 have been shown to be gene products of a new stability system, ParD, of plasmid R1.
  • (19) We have now shown that, in addition to the parD mutation, OV6 carries a gyrAam mutation and that this mutation is probably responsible for the gross phenotype of the mutant.
  • (20) Two divergently arranged promoters located in the intercistronic region between parC and parD mediate transcription of these genes.

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