(superl.) Not easily penetrated, cut, or separated into parts; not yielding to pressure; firm; solid; compact; -- applied to material bodies, and opposed to soft; as, hard wood; hard flesh; a hard apple.
(superl.) Difficult, mentally or judicially; not easily apprehended, decided, or resolved; as a hard problem.
(superl.) Difficult to accomplish; full of obstacles; laborious; fatiguing; arduous; as, a hard task; a disease hard to cure.
(superl.) Difficult to resist or control; powerful.
(superl.) Difficult to bear or endure; not easy to put up with or consent to; hence, severe; rigorous; oppressive; distressing; unjust; grasping; as, a hard lot; hard times; hard fare; a hard winter; hard conditions or terms.
(superl.) Difficult to please or influence; stern; unyielding; obdurate; unsympathetic; unfeeling; cruel; as, a hard master; a hard heart; hard words; a hard character.
(superl.) Not easy or agreeable to the taste; stiff; rigid; ungraceful; repelling; as, a hard style.
(superl.) Rough; acid; sour, as liquors; as, hard cider.
(superl.) Abrupt or explosive in utterance; not aspirated, sibilated, or pronounced with a gradual change of the organs from one position to another; -- said of certain consonants, as c in came, and g in go, as distinguished from the same letters in center, general, etc.
(superl.) Wanting softness or smoothness of utterance; harsh; as, a hard tone.
(superl.) Rigid in the drawing or distribution of the figures; formal; lacking grace of composition.
(superl.) Having disagreeable and abrupt contrasts in the coloring or light and shade.
(adv.) With pressure; with urgency; hence, diligently; earnestly.
(adv.) With difficulty; as, the vehicle moves hard.
(adv.) Uneasily; vexatiously; slowly.
(adv.) So as to raise difficulties.
(adv.) With tension or strain of the powers; violently; with force; tempestuously; vehemently; vigorously; energetically; as, to press, to blow, to rain hard; hence, rapidly; as, to run hard.
(adv.) Close or near.
(v. t.) To harden; to make hard.
(n.) A ford or passage across a river or swamp.
Example Sentences:
(1) Lucy and Ed will combine coverage of hard and breaking news with a commitment to investigative journalism, which their track record so clearly demonstrates”.
(2) Sierra Leone is one of the three West Africa nations hit hard by an Ebola epidemic this year.
(3) Topical and systemic antibiotic therapy is common in dermatology, yet it is hard to find a rationale for a particular route in some diseases.
(4) Given Australia’s number one position as the worst carbon emitter per capita among major western nations it seems hardly surprising that islanders from Fiji, Samoa, Vanuatu and other small island developing states have been turning to Australia with growing exasperation demanding the country demonstrate an appropriate response and responsibility.
(5) They had learned through hard experience what Frederick Douglass once taught -- that freedom is not given, it must be won, through struggle and discipline, persistence and faith.
(6) In 60 rhesus monkeys with experimental renovascular malignant arterial hypertension (25 one-kidney and 35 two-kidney model animals), we studied the so-called 'hard exudates' or white retinal deposits in detail (by ophthalmoscopy, and stereoscopic color fundus photography and fluorescein fundus angiography, on long-term follow-up).
(7) It is a moment to be grateful for what remains of Labour's hard left: an amendment to scrap the cap was at least tabled by John McDonnell and Jeremy Corbyn but stood no chance.
(8) She stopped working only when the pain made it hard for her to get to work.
(9) He was reclusive, I know that, and he was often given a hard time for it.
(10) This defeat, though, is hardly a good calling card for the main job.
(11) Since this test is easily performed and hardly stresses the patient, it should routinely be the initial one for the diagnosis of renal osteopathy.
(12) Never become so enamored of your own smarts that you stop signing up for life’s hard classes.
(13) But I don't wish to be too hard on the judge for not taking that view.
(14) Our campaign has been going for some time and each step in our progress has been hard won, by campaigners paid and volunteer alike.
(15) I am rooting hard for you.” Ronald Reagan simply told his former vice-president Bush: “Don’t let the turkeys get you down.” By 10.30am Michelle Obama and Melania Trump will join the outgoing and incoming presidents in a presidential limousine to drive to the Capitol.
(16) All the same, it's hard to approach the school, which charges nearly £28,000 for boarders and nearly £19,000 for day girls and is sometimes called "the girls' Eton", without a few prejudices.
(17) Governmental officials as well as medical scientists in Taiwan have worked hard in recent years to develop and to implement various measures, such as prenatal diagnosis and neonatal screening, to lower the incidence of hereditary diseases and mental retardation in the population.
(18) Cooper, who was briefly a social worker in Los Angeles, also suggests working hard to build a rapport with colleagues in hotdesking situations.
(19) Critics of wind power peddle the same old myths about investment in new energy sources adding to families' fuel bills , preferring to pick a fight with people concerned about the environment, than stand up to vested interests in the energy industry, for the hard-pressed families and pensioners being ripped off by the energy giants.
(20) The spirit is great here, the players work very hard, we kept the belief when we were in third place and now we are here.
Resistant
Definition:
(a.) Making resistance; resisting.
(n.) One who, or that which, resists.
Example Sentences:
(1) Direct fetal digitalization led to a reduction in umbilical artery resistance, a decline in the abdominal circumference from 20.3 to 17.8 cm, and resolution of the ascites within 72 h. Despite this dramatic response to therapy, fetal death occurred on day 5 of treatment.
(2) It is supposed that delta-sleep peptide along with other oligopeptides is one of the factors determining individual animal resistance to emotional stress, which is supported by significant delta-sleep peptide increase in hypothalamus in stable rats.
(3) Fifty-six percent of Lac+ transconjugants were resistant to the S. cremoris M12R lytic phage.
(4) After stimulation with lipopolysaccharide and calcium ionophore A23187, culture supernatants of clones c18A and c29A showed cytotoxic activity against human melanoma A375 Met-Mix and other cell lines which were resistant to the tumor necrosis factor, lymphotoxin and interleukin 1.
(5) Injection of resistant mice with Salmonella typhimurium did not result in the induction of a population of macrophages that expressed I-A continuously.
(6) Results indicated a .85 probability that Directive Guidance would be followed by Cooperation; a .67 probability that Permissiveness would lead to Noncooperation; and a .97 likelihood that Coerciveness would lead to either Noncooperation or Resistance.
(7) The C3bi receptor on these cells, CR3, is resistant to elastase.
(8) The vascular endothelium is capable of regulating tissue perfusion by the release of endothelium-derived relaxing factor to modulate vasomotor tone of the resistance vasculature.
(9) One thing seems to be noteworthy in their opinion: the bacterial resistance of the germs isolated from the urine is bigger than the one of the germs isolated from the respiratory apparatus.
(10) Acquired drug resistance to INH, RMP, and EMB can be demonstrated in M. kansasii, and SMX in combination with other agents chosen on the basis of MIC determinations are effective in the treatment of disease caused by RMP-resistant M. kansasii.
(11) We conclude that chloramphenicol resistance encoded by Tn1696 is due to a permeability barrier and hypothesize that the gene from P. aeruginosa may share a common ancestral origin with these genes from other gram-negative organisms.
(12) These authors, therefore, conclude that this modified surgical approach is a viable alternative to the previously described procedures for resistant metatarsus adductus.
(13) The penicillin-resistant Enterococcus hirae R40 has a typical profile of membrane-bound penicillin-binding proteins (PBPs) except that the 71 kDa PBP5 of low penicillin affinity represents about 50% of all the PBPs present.
(14) Cop rats, however, possess a single 'suppressor' gene which confers complete resistance to mammary cancer.
(15) Both development of EDTA-resistant fibrinogen binding and fibrinogen association with the cytoskeleton were time dependent and reached maxima 45 to 60 minutes after fibrinogen binding to stimulated platelets.
(16) An inverse relationship between the pumping capacity of the heart and vascular resistance was confirmed at different stages of examination and treatment of the patients.
(17) This mobilization procedure allowed transfer and expression of pJT1 Ag+ resistance in E. coli C600.
(18) One rat strain (TAS) is susceptible to the anticoagulant and lethal effects of warfarin and the other two strains are homozygous for warfarin resistance genes from either wild Welsh (HW) or Scottish (HS) rats.
(19) Resistant mutants can be isolated only at concentrations of 1 M allylalcohol in the medium.
(20) A murine keratinocyte cell line that is resistant to the growth-inhibitory effects of transforming growth factor beta 1 (TGF beta 1) was examined for differential gene expression patterns that may be related to the mechanism of the loss of TGF beta 1 responsiveness.