(adv.) In a heavy manner; with great weight; as, to bear heavily on a thing; to be heavily loaded.
(adv.) As if burdened with a great weight; slowly and laboriously; with difficulty; hence, in a slow, difficult, or suffering manner; sorrowfully.
Example Sentences:
(1) Yesterday's flight may not quite have been one small step for man, but the hyperbole and the sense of history weighed heavily on those involved.
(2) However, self-efficacy (defined as confidence in being able to resist the urge to drink heavily) assessed at intake of treatment, was strongly associated with the level of consumption on drinking occasions at follow-up.
(3) 5 heavily pretreated patients with chronic lymphocytic leukaemia or non-Hodgkin lymphoma resistant to alkylating agents were treated with low-dose cytosine arabinoside (ARA-C).
(4) As it was, Labour limped in seven points and nearly two million votes behind the Conservatives because older cohorts of the electorate leant heavily to the Tories and grandpa and grandma turned up at the polling stations in the largest numbers.
(5) Modeling in epidemiological investigations depends heavily on work in experimental radiobiology.
(6) The Nigerian government has been heavily criticised for failing to protect civilians in an increasingly violent conflict that left about 10,000 dead last year.
(7) But in Annie Hall the mortality that weighs most heavily is the mortality of his love affair.
(8) [U-14C]Glucose failed to label choline-containing lipids in T. foetus but did so in T. vaginalis, with phosphatidylethanolamine again being heavily labeled.
(9) The practice of community nursing was heavily emphasized, and it was endeavored to strike a balance between hospital experience and work in communities themselves.
(10) The R&D team at Unilever, the British-Dutch behemoth that makes 40% of the ice creams we eat in the UK – Magnum, Ben & Jerry's, Cornetto and Carte D'Or among them – has invested heavily to create products that are both healthier and creamier.
(11) "There were around 50 attackers, heavily armed in three vehicles, and they were flying the Shebab flag," Maisori added, speaking from the town, where several buildings including hotels, restaurants, banks and government offices were razed to the ground.
(12) Paradigm relies heavily on social science research and analysis to help companies identify and address the specific barriers and unconscious biases that might be affecting their diversity efforts: things like anonymizing resumes so that employers can’t tell a candidate’s gender or ethnicity, or modifying a salary negotiation process that places women and minorities at a disadvantage.
(13) These occurred in the more heavily pretreated members of the cohort.
(14) PCB residues occurred only in snakes collected near a heavily-traveled highway.
(15) Ultrastructural examination of lepromatous nerves, on the other hand, showed the predominance of macrophages with large nucleus, heavily bacillated Schwann cells, and a few lymphocytes.
(16) Basic foodstuffs, such as flour, sugar and edible oils, are heavily subsidised.
(17) Light and electron microscopic analysis showed a high concentration of this enzyme in stellate cells, particularly heavily distributed under the organ capsule and scattered in the parenchyma, where they form a widespread three-dimensional network.
(18) Whereas granulosa cells in developing follicles were either unstained or lightly stained, the heavily luteinized granulosa cells of the preovulatory stimulated follicle were strongly positive for immunoreactive renin and angiotensin II.
(19) Self-reported abuse in the 6 months before interview had similar psychosocial correlates in both samples (heavily drinking friends, a positive attitude to heavy drinking, etc.).
(20) A thirty-seven year old male patient with heavily pretreated metastatic testicular carcinoma received escalating doses of recombinant human erythropoietin (EPO) before and throughout chemotherapy.
Overloaded
Definition:
(imp. & p. p.) of Overload
Example Sentences:
(1) By means of rapid planar Hill type antimony-bismuth thermophiles the initial heat liberated by papillary muscles was measured synchronously with developed tension for control (C), pressure-overload (GOP), and hypothyrotic (PTU) rat myocardium (chronic experiments) and after application of 10(-6) M isoproterenol or 200 10(-6) M UDCG-115.
(2) In iron-overloaded patients with primary haemochromatosis, there was inappropriately high uptake of iron by the biopsy specimens.
(3) The patient presented urgently for Caesarean section, with fluid overload and worsening thrombocytopaenia.
(4) Al hepatocytes overload appeared only in nuclei and not in nuclei and not in lysosomes, contrarily to chronic intoxications.
(5) Fluid overload, which could have been caused by the hyperosmolar properties of dextran, worsened progressively as fluids were drawn from the interstitial space and urine output was reduced.
(6) There were no significant differences between the mean levels of peak blood pressures (systolic, diastolic and mean), degree of fluid overload, and fractional sodium excretion in the 2 groups.
(7) Persisting diastolic dysfunction with a substantial rise in left ventricular filling pressure can be observed during dynamic exercise in postoperative patients with preoperative severe pressure overload hypertrophy.
(8) The 8 men and 3 women were clinically stable, were known to be compliant, and had no clinical evidence of aluminum overload; they were not receiving vitamin D supplements; and they had been on dialysis for an average of 65.6 months (range: 13-188 months).
(9) Wilson disease is due to a genetically determined impairment of copper excretion from liver into bile resulting in copper overload of the organism.
(10) There was no change in the sarcolemmal Mg2+ -ATPase of the left or right ventricle for the whole duration (3 to 9 months) of left ventricular pressure overload.
(11) These experimental results demonstrate that aluminium interferes with iron absorption and iron transfer, and suggest that these mechanisms may be responsible for maintaining and even increasing the anaemia observed in aluminium overload.
(12) When a high dose of the complex was administered, an overloading with hemosiderin of macrophages and hepatocytes was noticed.
(13) The subsequent accumulation of Na+ in the cell Na(+)-Ca2+ exchange, which can ultimately result in intracellular Ca2+ overload, contractile dysfunction and damage.
(14) If overloaded, these areas are subject to "cervical cratering," a common prelude to implant failure.
(15) The rationale for the inclusion of Mg in cardioplegic solutions therefore lies not in its cardioplegic properties, but in its ability to influence other cellular events such as the loss of Mg and K and perhaps to counter the detrimental effects of ischemia by antagonizing calcium (Ca) overload.
(16) Cardiac hypertrophy due to a chronic hemodynamic overload is accompanied by isoformic changes of two proteins of the thick filament of the sarcomere, myosin, and creatine phosphokinase.
(17) Age, gender and laboratory markers of iron overload did not differentiate patients with cardiac dysfunction (group 1) from those without cardiac dysfunction (group 2).
(18) Severe overloading can increase microdamage alarmingly, its repair by BMUs too, and can cause woven bone formation, anarchic resorption and a regional acceleratory phenomenon.
(19) Thus, it appears that the increased expression of the regulatory MLC2 gene in SHR atrial cells is a predetermined event, which, most likely, participates in functional adaptation of the myocardium in response to pressure overload and subsequent hypertrophy.
(20) To help resolve the issue of contractile function in volume overload hypertrophy, we examined ventricular function in a recently described model of severe chronic experimental mitral regurgitation.