(1) The first concerns precursor cells that give rise to lambda-bearing NP-specific antibodies with heteroclitic fine specificity.
(2) The data suggest that the humoral response to different epitopes of a protein antigen during the maturation of the immune response is a stochastic process leading to transient humoral immunodominance, enhancing Ab populations and heterocliticity, depending upon individual characteristics, either in outbred or inbred populations.
(3) The goal of these experiments has been to capitalize on the functionally distinct responses of heteroclitic CTL to cross-reactive Ag to explore the role of Ag in regulating CTL proliferation and lytic function.
(4) It is predicted that a combination of solid-phase competition assay with high epitope density and direct binding assay with low epitope density would result in optimal detection of heteroclitic antibodies and small differences in antibody affinity for cross-reactive antigens.
(5) By contrast, the heteroclitic Abs to eGH developed by hypopituitary patients therapeutically injected with human growth hormone failed to react with any eGH-derived fragment.
(6) m ABs 8 to 14 and 16 to 20 demonstrated heteroclitic behavior, that is, they bound CTT IIIa better than the immunogen CTT III.
(7) One assay method failed to detect heteroclitic activity of 1 antibody which was clearly evident in the other 3 assays.
(8) Moreover, some anti-BP mAbs and anti-Cop 1 mAbs reacted in a heteroclitic manner and favored the cross-reactive antigen over the immunogen.
(9) However, immunization with the heterologous peptide resulted in a response strictly directed to rat CII and the immunogen while immunization with the autologous peptide elicited T cells which reacted in a heteroclitic fashion, with a stronger response to the heterologous peptide than to the autologous peptide, and did respond to rat CII but not to mouse CII.
(10) Polypeptides (Lys-Ser-Glu)n induced cross-reacting or heteroclitic antibodies.
(11) Monoclonal and anti-dinitrophenyl and anti-trinitrophenyl IgE antibodies were used to measure heterocliticity using competitive inhibition assays with homologous and heterologous haptens.
(12) To our knowledge, this is the first description of a T cell clone that is specific for a class I antigen and cross-reacts heteroclitically with a class II antigen.
(13) A number of antibodies showed heteroclitic binding to particular insulin variants.
(14) Med., 146 (1977) 1323-1331), by comparing the encephalitogenic guinea pig sequence to a less potent analog, had also previously observed what now would be termed a heteroclitic phenomenon at the T cell level in Lewis rats.
(15) In this report, we employ a competition assay to confirm that this alloresponse involves a groove-binding peptide, demonstrate that this peptide derives from or depends on fetal calf serum and exploit a panel of antigen-presenting cell lines--each displaying an Ak complex with a different position 69 substitution--to establish that the alloresponse is not just a heteroclitic response to ribonuclease, itself.
(16) The results indicated temporal and individual variations in the titers of each class of Ab as well as the existence of enhancer and heteroclitic Ab.
(17) Products of both genes had an exotic (heteroclitic) fine-specificity.
(18) Although most of the animals showed cross-reacting Ab, two out of 12 mice, chronically injected, developed heteroclitic Ab.
(19) Heterocliticity towards non-human GH was also detected.
(20) Some of the antibodies could be inhibited to a greater degree with the cross-reacting haptens than with the haptens homologous to the immunizing antigen, therefore these antibodies were heteroclitic.
Inanimate
Definition:
(v. t.) To animate.
(a.) Not animate; destitute of life or spirit; lifeless; dead; inactive; dull; as, stones and earth are inanimate substances.
Example Sentences:
(1) The local inanimate environment, including mess hut, sleeping huts and sleeping bags used on expeditions, was searched for contamination by S. aureus but none was detected.
(2) The rats also had the opportunity to make noncontingent target biting responses on an inanimate target.
(3) The subjects' fears reflected the trauma, they feared inanimate objects, and there were hardly any paranoid ideations.
(4) In standardized tests of huddling behavior, 5-, 10-, 15-, and 20-day-old rat pups spent substantial and equivalent amounts of time with an immobile rat or a heated, fur-covered tube, which suggests that the conspecific and inanimate stimuli were equally attractive to the pups.
(5) The animals learned to discriminate between pictures of faces or inanimate objects, to select the odd face from a group, to inspect a face then select the matching face from a pair of faces after a variable delay, to discriminate between novel and familiar faces, and to identify specific faces.
(6) They are even absorbed by inanimate elements, or by ordinary objects of everyday life.
(7) The chloramphenicol-treated cells, as well as cells of a transposon-generated mutant strain deficient in peripheral EPS formation, remained adhesive to a hydrophobic inanimate surface during the initial 5 h of starvation, whereas nontreated wild-type cells had progressively decreased adhesion capacity.
(8) The use of this technique results in high titers of virus on cover slips, which are inanimate objects requiring minimal manipulation.
(9) Results for inanimate objects agree within 1 percent with comparable measurements by water displacement.
(10) It is highly unlikely that the essence of the process lies in its computational logic and hence it can never be produced by inanimate machines.
(11) The ventilation system, air conditioning plant, air and inanimate sources in the operating theatre were investigated.
(12) The ecosystem encloses all living organisms as well as the inanimate environment (e.g.
(13) Germans are applauded in the language we use to describe well-functioning inanimate objects, such as Mercedes cars, or Miele dishwashers.
(14) In inanimate sources, P4 was predominant in water and sewage effluent.
(15) The usefulness of S. marcescens biotyping was shown by relating several isolates recovered from patients and their inanimate environment and by pointing out the possible existence of infections or colonizations by two unrelated biotypes.
(16) I’ve always been fascinated by how these inanimate objects harness this explosion.
(17) Visual fixation time was compared for events in which an inanimate object moved independently and events in which a human being was the agent.
(18) Texts were carried out on strains derived from the respiratory tract, strains from infection at other sites, and strains from the inanimate hospital environment which were believed not to have been responsible for infection ('environmental' strains).
(19) Infant observation indicated that there is an individual variation in development characterized by orientedness either toward the animate or toward the inanimate world.
(20) Similar to the modern sculptor of inanimate art forms, plastic surgeons have utilized new materials and devised new techniques to achieve aesthetic improvement of the face, trunk, and extremities.