(a.) Differing in kind; having unlike qualities; possessed of different characteristics; dissimilar; -- opposed to homogeneous, and said of two or more connected objects, or of a conglomerate mass, considered in respect to the parts of which it is made up.
Example Sentences:
(1) Size analysis of the solubilized IgA IP employing sucrose density gradient ultracentrifugation, indicated that these were heterogeneous, with a size generally larger than 19 S.
(2) Over the past decade the use of monoclonal antibodies has greatly advanced our knowledge of the biological properties and heterogeneity that exist within human tumours, and in particular in lung cancer.
(3) The 0.1 M phosphate buffer eluant was electrophoretically heterogeneous and did not elicit the production of bactericidal antibodies in rabbits.
(4) HCECs display an unusual combination of cytokeratin IFs and neurofilaments, together with vimentin, and are heterogeneous with respect to their IF makeup.
(5) mycoides cluster' at a similarity level (S) of 66% and which remained undivided at up to 78% S. At higher similarity levels, these strains fell heterogeneously into mixed sub-phenons containing strains of both subspecies.
(6) Much information has accumulated on the isolation and characterization of a heterogeneous group of molecules that inhibit one or more of the bioactivities of interleukin 1.
(7) The combined results suggest that any possible heterogeneity in the L-CAM genes is not reflected in the size of either the mRNA or protein.
(8) The diagnosis of "autism" has been used to encompass a heterogeneous group of children who may differ in etiology, clinical manifestations, prognosis, and needed treatment.
(9) Osteogenesis imperfecta is the common term for a heterogeneous group of heritable disorders of connective tissue with lethal and nonlethal forms.
(10) High pressure liquid chromatography combined with radioimmunoassay showed marked heterogeneity of SPLI and SLI.
(11) The heterogeneity of obesity may be demonstrated by the shape of fat distribution and the prolactin response to insulin hypoglycaemia.
(12) The antibody-hapten profiles revealed that the DNCB-fed animalss contained predominatly IgG2 in their serum by the time of their initial bleedings, whereas sensitized animals still contained a considerable proportion of more acidic antibodies having marked charge heterogeneity.
(13) We detected no evidence for heterogeneity in this sample, but when we combined results with previously published lod scores, heterogeneity was statistically significant.
(14) The operational meaning of all the resulting theorems is that when any of them appear to be refuted experimentally, the presence of more than one parallel transport pathway (that is, of membrane heterogeneity transverse to the direction of transport) can be inferred and analyzed.
(15) Possible interpretations of this manifestation of biological heterogeneity are discussed.
(16) The heterogeneity of the muscarinic receptors was examined both in vivo and in radioligand binding experiments.
(17) This work shows that during 3MeDAB hepatocarcinogenesis, AFP gene activation occurs in heterogenous cell populations and according to different cellular patterns.
(18) The resistance to cephalosporins of 48 heterogeneous methicillin-resistant strains ("RH" mutants) of Staphylococcus pyogenes var.
(19) Results indicate that nystatin is distributed heterogeneously in the gastrointestinal tract.
(20) The major scrapie prion protein, designated PrP 27-30, exhibited both charge and size heterogeneity after purification from infected hamster brains.
Piebald
Definition:
(a.) Having spots and patches of black and white, or other colors; mottled; pied.
(a.) Fig.: Mixed.
Example Sentences:
(1) Male and female rats of the inbred Piebald Virol Glaxo ( PVG) and Sprague Dawley (SD) strains were infected with 20 metacercariae of Fasciola hepatica.
(2) Using DNA of a patient with piebaldism, mental retardation, and multiple congenital anomalies associated with a 46,XY,del(4) (q12q21.1) karyotype, we carried out quantitative Southern blot hybridization analyses of the KIT gene and the adjacent PDGFRA (platelet-derived growth factor receptor alpha subunit) genes.
(3) Seven piebald lethal (PLM) mice with histologically verified aganglionosis and seven normal littermates (NLM) were sacrificed.
(4) Effects of hypoxia and hypothermia on the poststimulus rebound contractile response (PSRR) were studied in the circular muscle coat of the large intestine of the piebald mouse model for Hirschsprung's disease.
(5) The authors describe peculiar tumors with brown-white piebald anterior surface, which had grown bilaterally from the corpora nigra (C.N.)
(6) Controls of Piebald Virol Glaxo, Wistar and DA rats were also employed.
(7) Two other frequent colours are white spotting, due to the piebald allele (sp), and the chinchilla allele (ch).
(8) The results indicate that the distended portion of the colon of piebald mice is capable of coordinated peristalsis and that accumulation of feces and megacolon are secondary to the terminal obstruction that results from absence of coordinated propulsive activity in the hypoganglionic terminal segment.
(9) It is concluded that cholinergic innervation is congenitally absent in the aganglionic rectum in piebald lethal mice.
(10) Significant histological and immunocytochemical differences were seen in the ganglionic segment of colon between piebald mice with early clinical onset of acute illness and piebald mice with late onset enterocolitis.
(11) Human piebaldism is an expression of neural crest component abnormality that is classically inherited dominantly and is probably heterogeneous genetically.
(12) Here, pigmented skin around the axilla was transplanted to hypomelanotic areas in two patients with piebaldism.
(13) Vitreous fluorophotometry was performed on pigmented male rats (Piebald strain) 2 weeks after induction of diabetes by streptozotocin.
(14) The experiments were conducted on bulls-analogs of the black-piebald and Simmental breed which differ from each other in the intensity of live weight gain (18-31%) as well as on lactating cows-analogs of the black-piebald breed which differ in the level of milk productivity (41-80%).
(15) In the muscles of bulls the activity of phosphoglucomutase, phosphohexoisomerase, aldolase and fructose-1,6-diphosphatase is considerably higher (except of the activity of phosphoglucomutase and phosphohexoisomerase in the muscles of pure-bred black-piebald animals for which difference is not statistically reliable) and the content of glycogen, glucose, fructose, lactic acid, free and phosphorylated pentoses of nonadenylic compounds is essentially lower than in the muscle tissue of heifers of analogous breed groups.
(16) Comparative study of achromic and normally pigmented skin of three piebald patients from two families is reported here.
(17) This same region also contains genes for two of the structurally related factors, for c-kit, a receptor for an as yet unidentified ligand, and for 'piebald trait', an inherited skin pigmentation disorder.
(18) The latency and duration of the PSRR were increased during hypothermia while the amplitude decreased in all ganglionated regions of large intestinal preparations from both piebald mice and their normal siblings.
(19) In the course of the investigation of piebald (black-white) cattle it is found that 17,62% animals produce the AA type beta-lactoglobulin, 49,52%--the AB type and 32,86%--the BB type.
(20) The similarities between piebaldism and the Waardenburg syndromes are discussed.