(a.) Characterized by integrity or fairness and straight/forwardness in conduct, thought, speech, etc.; upright; just; equitable; trustworthy; truthful; sincere; free from fraud, guile, or duplicity; not false; -- said of persons and acts, and of things to which a moral quality is imputed; as, an honest judge or merchant; an honest statement; an honest bargain; an honest business; an honest book; an honest confession.
(a.) Open; frank; as, an honest countenance.
(a.) Chaste; faithful; virtuous.
(a.) To adorn; to grace; to honor; to make becoming, appropriate, or honorable.
Example Sentences:
(1) We have not yet been honest about the implications, and some damaging myths have arisen.
(2) Does anybody honestly believe the vast majority of migrants don’t want that too?
(3) We didn’t take anyone’s votes for granted and we have run a very strong positive campaign.” Asked if she expected Ukip to run have Labour so close, she said: “To be honest with you I have been through more or less every scenario.
(4) The military is not being honest about the number of men on strike: most of us are refusing to eat.
(5) The World Humanitarian Summit in May 2016 may be the most timely opportunity to make an honest appraisal of the effectiveness of the current system to deal with the sector’s “ new normal ” of finite resources and unlimited challenges.
(6) How, in the name of all that is decent and honest in this world did we let this happen?
(7) We are prepared to be honest with people and say that we will all need to chip in a little more.” The party’s health spokesman, Norman Lamb, said: “The NHS was once the envy of the world and this pledge is the first step in restoring it to where it should be.
(8) The Sun editor also said his newspaper was wrong to use the word "tran" in a headline to describe a transexual, saying that he felt that "I don't know this is our greatest moment, to be honest".
(9) I have always struggled with the quality of my own work but despite my misgivings about the photos I am taking I can't honestly say they would have been any better two years ago.
(10) She described Luke as being “open, honest and assertive” during the interview.
(11) The physician embarking on the long-term management of burned children must have a very strong and honest relationship with the patient and family or guardians and must use all available resources, including physical and occupational therapists, social workers, and others, over the course of the effort.
(12) First, they were asked to complete them honestly, reporting accurately on their behaviour patterns.
(13) Including these incentive or responsibility payments in fixed pay is also more honest in accounting terms.
(14) Right now I think the discussion is not honest and practical, it is hysterical and political.” In contrast to the IOC, which did not contact McLaren, he said the International Paralympic Committee had been in close touch as it decides on whether to ban the Russian team.
(15) "I'm just trying to be objective and honest," he says.
(16) Camila Batmanghelidjh is one of the most kind-hearted, honest and reliable people I know, and would do anything not only for her young people but for young people in general.
(17) Another – the problem they failed to solve at the last election – is how you write an honest manifesto of your liberalism when you know and the voters know that, if you do get to see power again, it will be shared with someone else.
(18) While this is something that gives substance to the familiar cry of “Never again,” it will be up to the countries in the western Balkans, and in particular Bosnia and Herzegovina, to engage in an honest reckoning with the past, rather than narratives based on chauvinism or denial.
(19) I honestly think so many Americans are scrambling so fast just to keep up that: a) they're not aware of what they're missing; b) they don't have time to agitate."
(20) Green party leader Natalie Bennett came unstuck by trying to be honest | Letters: Sara Parkin, Brian Wilson and Tim Daniel Read more Having announced the idea of a universal £72-a-week income in January, the party has struggled to say how it would raise the billions of pounds needed to implement the policy and faced questions about whether it would harm the poorest people.
Malice
Definition:
(n.) Enmity of heart; malevolence; ill will; a spirit delighting in harm or misfortune to another; a disposition to injure another; a malignant design of evil.
(n.) Any wicked or mischievous intention of the mind; a depraved inclination to mischief; an intention to vex, annoy, or injure another person, or to do a wrongful act without just cause or cause or excuse; a wanton disregard of the rights or safety of others; willfulness.
(v. t.) To regard with extreme ill will.
Example Sentences:
(1) After addition of triiodothyronine, malic enzyme mRNA accumulated with sigmoidal kinetics, approaching a new steady state at 36-48 h after adding hormone.
(2) In addition to detecting three major antigenic variants of malic enzyme within this group, both antisera readily reacted with Streptococcus faecalis malic enzyme.
(3) The oxidative enzymes of the pentose phosphate pathway, ATP-citrate lyase, 'malic' enzyme and fatty acid synthetase also decrease markedly.
(4) Hormone therapy also caused an increase in the rate of incorporation of [3H]leucine into soluble proteins and in malic enzyme activity.
(5) Moreover, the transcriptional rate, mRNA concentration and induction of malic enzyme were increased by triiodothyronine treatment at a similar rate in both the young and old rats, but the absolute increments were lower in the old animals.
(6) The TRH treatment suppressed mitochondrial cytochrome c reductase and glucose-6-phosphatase activities, whereas cyclo(His-Pro) reduced cytochrome c reductase and malic enzyme activities.
(7) Activities of glucose-6-phosphate dehydrogenase and malic dehydrogenase of the mycelial form were higher than those of the yeast form.
(8) These observations suggest that in the rat neostriatum there are some neurons especially able to catabolize pyruvate via cytosolic malic isoenzyme.
(9) Thus a long-lived event in thyroid hormone stimulation of malic enzyme synthesis occurred prior to transcription of a specific messenger RNA (mRNA), presumably malic enzyme mRNA.
(10) In the Ob 17 preadipocyte cell line, during adipose differentiation, T3 amplified the progressive expression of two enzymes of the lipogenic pathway, ATP-citrate lyase (ATP-CL) and malic enzyme (ME) as previously described for fatty acid synthase (FAS) and fatty acid synthesis, and in the same time-period of development.
(11) The nucleotide sequence of the mRNA for malic enzyme ((S)-malate NADP+ oxidoreductase (oxaloacetate-decarboxylating, EC 1.1.1.40) from rat liver was determined from three overlapping cDNA clones.
(12) The specific nuclear binding of triiodothyronine (T3) (NBT3) and the activity of malic enzyme (ME), glucose-6-phosphate-dehydrogenase (G6PD), and 6-phosphogluconate-dehydrogenase (6PGD) were studied in the human fibroblast cell (MRC-5).
(13) 2-Hydroxyisobutyric acid, ethyl-2-hydroxybutyrate, malic acid, 1-butanol, benzyl alcohol and L-leucine did not act as substrates for the enzymes.
(14) Malic enzyme and glucose-6-phosphate dehydrogenase were highly active in the adipose tissue of mammals but were inactive in the adipose tissue of birds.
(15) Distribution of kinase activity in centrifugal fractions of both liver and heart mitochondrial sonicates was parallel to that of the two inner membrane marker enzymes succinic dehydrogenase and cytochrome oxidase and quite different from that of the matrix enzyme malic dehydrogenase.
(16) Glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and malic enzyme are enzymes involved in NADPH synthesis.
(17) The antigenic enzymes, the precipitates of which are only stained by specific staining, are: aldolase, malic enzyme, acid phosphatase, peroxydase and cholinesterase.
(18) The coupling enzymes, fumarase (fumarate to L-malate) and malic enzyme (L-malate to pyruvate and NADPH), are adsorbed to nitrocellulose prior to blotting.
(19) The latter region apparently includes the malic dehydrogenase-1 gene.
(20) Some reactions, such as malic enzyme and glutamate dehydrogenase, may be inhibited or deleted with little or no adverse effect on the calculated cell growth rate.