(1) The results obtained to date are not sufficient to allow the mechanism of action of HUGI to be defined.
(2) Refresh the page and there's a non-technicolour snap of 1954 hat-trick hero Josef Hugi down there now.
(3) Negative results were obtained in the other tests, but these results serve to demonstrate that HUGI is an inhibitor well-differentiated from other glycoproteins or peptides with gastric antisecretory activity, such as urogastrone and GIP.
(4) HuGi were incubated with H3 32PO4, stimulated with PMA or cytokines, and EGF-R were immunoprecipitated; IL-1 and TNF, like PMA, caused a 2- to 5-fold increase in receptor phosphorylation.
(5) The gastric antisecretory activity of an inhibitor newly isolated from human urine (Human Urinary Gastric Inhibitor or HUGI) has been studied.
(6) Josef Hugi, the only Swiss player other than Xherdan Shaqiri to score a hat-trick at the World Cup finals.
(7) Competition experiments at 4 degrees C showed that the cytokines did not interact directly with EGF-R; Scatchard analysis of binding of [125I]EGF to HuGi after treatment with IL-1 and TNF revealed an increase in EGF-R Kd from 0.75 nM to 2.9 nM with no change in receptor number.
(8) HUGI was given intravenously and its activity determined in the following test systems: gastric secretion in the rat with pyloric ligation; gastric secretion in the dog with a Heidenhain pouch stimulated with pentagastrin, histamine and a protein meal; acid secretion by the isolated gastric mucosa of the rat; gastrointestinal motility; bile flow and gall-bladder tone and arterial and venous blood pressure and heart rate.
(9) Exposure of quiescent cultures of human gingival fibroblasts (HuGi) and porcine synovicocytes (PSF) to human recombinant interleukin 1 alpha or -beta (IL1 alpha and -beta) enhanced the rate of glycolysis as judged by increased lactate production.
(10) Half-maximal stimulation occurred at approximately 1 pM IL1; maximal stimulation (2.5-4.5-fold in HuGi, 3-7-fold in PSF) was obtained with approximately 80 pM IL1.
(11) Importantly, in HuGi made deficient in protein kinase C by prolonged incubation with PMA, addition of fresh PMA no longer affected EGF binding, while the response to IL-1 and TNF was intact.
(12) The effect of the human rIL-1 alpha and rTNF-alpha on the binding of 125I-labeled epidermal growth factor ([125I]EGF) to its receptor (EGF-R) has been studied in human gingival fibroblasts (HuGi).
(13) HUGI was found to have marked activity only in the pyloric-ligated rats and in the dogs with Heidenhain pouches stimulated by a protein meal.
(14) HuGi cells were pulse-labeled with [35S]methionine following exposure to IL1.
(15) The effect of IL-1 and TNF on EGF-R was compared with that of the tumor-promotor PMA which is known to "transmodulate" EGF-R affinity by activating protein kinase C which then phosphorylates EGF-R. PMA caused a greater inhibition of EGF binding to HuGi (80 to 85% inhibition; ED50 = 500 pM), and recovery of binding was much slower.
Vast
Definition:
(superl.) Waste; desert; desolate; lonely.
(superl.) Of great extent; very spacious or large; also, huge in bulk; immense; enormous; as, the vast ocean; vast mountains; the vast empire of Russia.
(superl.) Very great in numbers, quantity, or amount; as, a vast army; a vast sum of money.
(superl.) Very great in importance; as, a subject of vast concern.
(n.) A waste region; boundless space; immensity.
Example Sentences:
(1) It is a place that occupies two thirds of our planet but very little is known of vast swaths of it.
(2) In this phase the educational practices are vastly determined by individual activities which form the basis for later regulations by the state.
(3) The effects of brain injury can be catastrophic and long-term so the impact of more research would be vast, but affected numbers are too small so it loses out.
(4) Does anybody honestly believe the vast majority of migrants don’t want that too?
(5) The vast majority of small cells were probably displaced amacrine cells.
(6) I never had any doubt that the vast majority of people engaged in "business" are not the exploiters but the exploited.
(7) In response, detainees – the vast majority of them failed asylum seekers who have committed no crime – waved and shared messages of solidarity.
(8) Not because we are “chippy, moronic gits” (thank you, Twitter), but because we do not see the social benefit of a two-tier education system that provides a small minority with vastly more opportunities than the rest.
(9) It is important to pay attention to the outcome of this study in (postgraduate) education for general practitioners, as they treat the vast majority of urethritis patients.
(10) The drugs used in early studies - diuretics, vasodilators and reserpine - greatly improved mortality from malignant hypertension, apoplectic stroke and congestive heart failure, but had little or no effect in persons with milder degrees of elevated blood pressure, who constitute the vast majority of hypertensives.
(11) We report that specific human (dC-dA)n.(dG-dT)n blocks are polymorphic in length among individuals and therefore represent a vast new pool of potential genetic markers.
(12) The discovery of this vast tranche of documents has prompted historians to suggest that a major reappraisal of the end of Britain's empire will be required once these materials have been digested – a "hidden history" if ever there were one.
(13) The vast majority of the epithelial cells were secretory, and the rest were ciliated.
(14) Even the landscape is secretive: vast tracts of crown land and hidden valleys with nothing but a dead end road and lonely farmhouse, with a tractor and trailer pulled across the farmyard for protection.
(15) Lethal pulmonary embolism is associated with hypoxemia and hypocapnia in the vast majority of cases.
(16) The vast majority of members would rather have a quiet body, offering technical assistance here and there and convening an occasional summit.
(17) Europe was never going to be another America or Soviet Union, with one constitution imposing national homogeneity over vast distances, and with people and investment migrating ceaselessly in search of employment.
(18) In the southern state of Karnataka, corruption is blamed for uncontrolled mining in vast areas of protected forest.
(19) Mali: a guide to the conflict Read more In response, the Tuareg separatists attacked military and police points as far as Tenenkou in the south, to prove it still controlled vast swaths of the desert territory.
(20) The vast majority of the subjects had correctly been given the diagnosis of cerebrovascular disease.