(1) Moreover, one possible mechanism of intracellular insulin degradation is that cell surface IDE may be internalized with the insulin receptor complex and may degrade insulin during the intracellular process.
(2) These results demonstrate that the IDE is evolutionarily conserved and that its expression is tightly regulated during differentiation of Drosophila.
(3) A ventrally localized melanization inhibiting factor (MIF) has been suggested to play an important role in the establishment of the dorsal-ventral pigment pattern in Xenopus laevis [Fukuzawa and Ide:Dev.
(4) The addition of NADPH to the membranes was shown to result in the conversion of inactive protochlorophyll (ide) absorbing at about 630 nm into a form(s) with light-absorption maxima at about 640 and 652 nm, both of which disappear when chlorophyll (ide) is formed on illumination.
(5) When IDE particles are injected intravenously, the Kupffer cells of the hepatic sinusoids accumulate particles within 10 to 20 minutes, after which the clearance and excretion of IDE takes place.
(6) On the other hand the lingual IDE withdraw from the cell cycle before the corresponding labial cells.
(7) Immunoblotting experiments demonstrate that this inhibition is mediated by the reactivity of these mAbs with a 110 kDa protein, the known M(r) of IDE.
(8) A stereospecific high-performance liquid chromatographic method for the determination of (R,S)-flecainide acetate [(R,S)-N-(2-piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzam ide acetate] in human plasma and urine is described.
(9) A rapid, sensitive high-performance liquid chromatographic method has been developed for the determination of desmosine (DES) and isodesmosine (IDE), the specific cross-linking amino acids of elastin, in the tissue hydrolysates of rats.
(10) Two minutes after injection, intra- and extracellular IDE particles were found in the red pulp of the spleen.
(11) An insulin-degrading enzyme (IDE) was purified from the cytosol of human erythrocytes via the use of ammonium sulfate precipitation and chromatography on columns composed of DEAE-Sephadex, pentylagarose, hydroxylapatite, chromatofocusing resins, and Ultrogel AcA-34.
(12) Since some of these peptides have insulin-like properties, amino acid analysis of these products may enable us to identify not only the splitting position of insulin by IDE but also the site of the hormone for receptor binding.
(13) A fully automated readout unit for the BG-8 blood-grouping machine, printing Idee identification numbers with matching ABO grouping and rhesus (D) typing results is described.
(14) In vitro incubation experiments confirmed that human PMNs ingest IDE particles.
(15) The relaxant effect of cromakalim (BRL 34915), pinacidil and RP 49356 (N-methyl-2-(3-pyridyl)-tetrahydro-thiopyran-2-carbothioamide-1-ox ide) on the sustained contractions induced by 20 mM KCl were compared with the effects of nicorandil.
(16) [4R,(2E,5E)]-3-Hydroxy-2,4,6-trimethyl-2,5,7-octatriene-4-thiol ide, C11H14O2S, Mr = 210.30, hexagonal, P6(5), a = b = 9.8514 (6), c = 19.954 (1) A, V = 1677.1 A3, Z = 6, Dx = 1.249 g cm-3, lambda(Cu K alpha) = 1.5418 A, u = 23.07 cm-1, F(000) = 672, T = 298 K, R = 0.028 for 1021 unique reflections [Fo2 greater than 2 sigma(Fo2)].
(17) Row III IDE cells are also devoid of organelles related to secretory protein synthesis, although these IDE cells accumulated large pools of intracellular glycogen.
(18) Indirect studies based upon inhibitors, degradation products, and microinjected antibodies have suggested that the IDE can initiate cellular insulin degradation in mammalian cells.
(19) To further localize the site of IDE action, the fate of insulin after receptor binding was examined.
(20) In her book "Vårdandets Ide" the Finnish nurse, Katie Eriksson puts forward the thesis, that all kind af caring activities do have a common core.
Wide
Definition:
(superl.) Having considerable distance or extent between the sides; spacious across; much extended in a direction at right angles to that of length; not narrow; broad; as, wide cloth; a wide table; a wide highway; a wide bed; a wide hall or entry.
(superl.) Having a great extent every way; extended; spacious; broad; vast; extensive; as, a wide plain; the wide ocean; a wide difference.
(superl.) Of large scope; comprehensive; liberal; broad; as, wide views; a wide understanding.
(superl.) Of a certain measure between the sides; measuring in a direction at right angles to that of length; as, a table three feet wide.
(superl.) Remote; distant; far.
(superl.) Far from truth, from propriety, from necessity, or the like.
(superl.) On one side or the other of the mark; too far side-wise from the mark, the wicket, the batsman, etc.
(superl.) Made, as a vowel, with a less tense, and more open and relaxed, condition of the mouth organs; -- opposed to primary as used by Mr. Bell, and to narrow as used by Mr. Sweet. The effect, as explained by Mr. Bell, is due to the relaxation or tension of the pharynx; as explained by Mr. Sweet and others, it is due to the action of the tongue. The wide of / (/ve) is / (/ll); of a (ate) is / (/nd), etc. See Guide to Pronunciation, / 13-15.
(adv.) To a distance; far; widely; to a great distance or extent; as, his fame was spread wide.
(adv.) So as to leave or have a great space between the sides; so as to form a large opening.
(adv.) So as to be or strike far from, or on one side of, an object or purpose; aside; astray.
(n.) That which is wide; wide space; width; extent.
(n.) That which goes wide, or to one side of the mark.
Example Sentences:
(1) In conclusion, the efficacy of free tissue transfer in the treatment of osteomyelitis is geared mainly at enabling the surgeon to perform a wide radical debridement of infected and nonviable soft tissue and bone.
(2) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(3) In this paper, we show representative experiments illustrating some characteristics of the procedure which may have wide application in clinical microbiology.
(4) Although antihistamines are widely used for symptomatic treatment of seasonal (allergic) rhinitis, the role of histamines in the pathogenesis of infectious rhinitis is not clear.
(5) When the data correlating DHT with protein synthesis using both labelling techniques were combined, the curves were parallel and a strong correlation was noted between DHT and protein synthesis over a wide range of values (P less than 0.001).
(6) It is my desperate hope that we close out of town.” In the book, God publishes his own 'It Getteth Better' video and clarifies his original writings on homosexuality: I remember dictating these lines to Moses; and afterward looking up to find him staring at me in wide-eyed astonishment, and saying, "Thou do knowest that when the Israelites read this, they're going to lose their fucking shit, right?"
(7) Migrant voters are almost as numerous as current Ukip supporters but they are widely overlooked and risk being increasingly disaffected by mainstream politics and the fierce rhetoric around immigration caused partly by the rise of Ukip,” said Robert Ford from Manchester University, the report’s co-author.
(8) Matthias Müller, VW’s chief executive, said: “In light of the wide range of challenges we are currently facing, we are satisfied overall with the start we have made to what will undoubtedly be a demanding fiscal year 2016.
(9) Breast conserving surgery in patients with small tumors combined with radiation therapy has gained wide popularity due to better cosmetic results without significant changes in survival.
(10) There are no oceans wide enough to stop us from dreaming.
(11) According to the national bank, four Russian banks were operating in Crimea as of the end of April, but only one of them, Rossiisky National Commercial Bank, was widely represented, with 116 branches in the region.
(12) It is widely seen as a counter to China’s economic might in Asia, and the world’s second largest economy is notably absent from the list of signatories.
(13) I wish to clarify that for the period 1998 to 2002 I was employed by Fifa to work on a wide range of matters relating to football,” Platini wrote.
(14) Label was found widely distributed among all the organs except the nervous system and its rate of disappearance from the tissues paralleled its disappearance from the circulation.
(15) Widely varying numbers of endocrine cells were identified in 12 out of 64 cases of uterine cancer in the course of histochemical and electron microscopic examination.
(16) These sera were derived from children with a wide range of tumor types.
(17) The results, together with the known geometry of the enzyme, indicate that active site probes in the dodecamer are widely separated and that energy transfer occurs from a single donor to two or three acceptors on adjacent subunits.
(18) We therefore conclude that widely spaced (and unknown) parts of the protein chain are required for the intersubunit interactions that eventually lead to functional assembly of the receptor.
(19) Plasma renin activities (PRA) and aldosterone concentrations increased in parallel over a wide range of plasma volume deficits produced in unanesthetized rats by extravascular administration of polyethylene glycol (PEG) solution.
(20) Second, the nurse must be aware of the wide range of feeling and attitudes on specific sexual issues that have proved troublesome to our society.