(1) Further analysis with two other synthetic peptides (212Cys to 222Glu and Cys X 221Ile to 236Glu) indicated that the dodecapeptide Ile-Glu-Phe-Gln-Lys-Asn-Asn-Arg-Leu-Leu-Glu mimicked either the whole or a major part of the neutralization epitope.
(2) In contrast, strains carrying the substitutions Ile-30----Phe, Gly-33----Leu, Gly-58----Leu, and Lys-34----Val and the Lys-34----Val, Glu-37----Gln double substitution were found to possess a coupled phenotype similar to that of the wild type.
(3) The commercially available chromogenic p-nitroanilide substrates Pro-Phe-Arg-NH-Np (S2302 or chromozym PK), Glp-Pro-Arg-NH-Np (S2366), Ile-Glu-(piperidyl)-Gly-Arg-NH-Np (S2337), and Ile-Glu-Gly-Arg-NH-Np (S2222) were tested for their suitability as substrates in these assays.
(4) We have named them bombolitin I (Ile-Lys-Ile-Thr-Thr-Met-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin II (Ser-Lys-Ile-Thr-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin III (Ile-Lys-Ile-Met-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin IV (Ile-Asn-Ile-Lys-Asp-Ile-Leu-Ala-Lys-Leu-Val-Lys-Val-Leu-Gly-His-Val-NH2 ), and bombolitin V (Ile-Asn-Val-Leu-Gly-Ile-Leu-Gly-Leu-Leu-Gly-Lys-Ala-Leu-Ser-His-Leu-NH2 ).
(5) Ile-tRNA synthetase shows little inactivation in either process.
(6) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(7) The minimal length for an effective substrate has been characterised as an octapeptide sequence derived from the amino terminal portion of angiotensinogen (residues 6----13): His-Pro-Phe-His-Leu-Val-Ile-His (Leu-Val is the scissile bond).
(8) The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid sequence of human growth hormone, was studied.
(9) The structures of two crystal forms of Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe have been determined.
(10) The alpha His58(E7) to Gly and Val62(E11) to Ala substitutions caused 80- and 3-fold increases, respectively, in k'CO for T-state alpha subunits, and the alpha Val62(E11) to Ile mutation caused a 3-fold decrease.
(11) Resonances from several amino acids including His 16, Gly 24, Ile 48, and Met 61 experience strong ring-current shifts due to their placement near the heme.
(12) The terminal sequences are: NH2-Ile-Val-Gly-Gly-Ile-Asp.....Gly-Lys-Tyr-Pro-Tyr-Gln-Val-Ser-Leu-Arg-COOH.
(13) Peptide mapping and amino acid sequence analyses have revealed that Val-406 of IgG1 carrying allotype a is substituted for Ile in the case of allotype j. X-ray crystallographic data indicate that Met-398 is in close spatial proximity to Val (Ile)-406.
(14) Site-directed mutation of codon 203 and transient expression of these cDNA in COS-7 cells indicated that Phe, Ile, Leu, and Val permit transmembrane expression, whereas Ser, Thr, Tyr, Asn, Gly, Ala, Asp and Lys enable phosphatidylinositol-glycan attachment.
(15) The N-terminal amino acid sequence of this sialidase, Ala-Asp-X-Ile-Phe-Val-Arg-Glu-Thr-Arg-Ile-Pro-, was determined.
(16) Supplementation of the low protein diet with a synthetic mixture of branched-chain AA (Val, Leu and Ile) normalized the plasma levels of these AA.
(17) They correspond to the sequence from Leu-149 to Ile-162.
(18) The N5 atom of flavin interacts with the amide NH of Ile 59 in A.
(19) Chymotrypsin cleavage of this peptide resulted in a single-labeled fragment with the sequence: Glu-Val-Ala-Asn-(Pyridoxal-P-Lys)-Val-Gly-Gly-Ile-Tyr.
(20) Both sarcosine-isoleucine-angiotensin II ([Sar, Ile]-ANG II) and atropine blocked, and nadolol increased, the effect of EFS and exogenous angiotensin II on serotonin production.
Rile
Definition:
(v. t.) To render turbid or muddy; to stir up; to roil.
(v. t.) To stir up in feelings; to make angry; to vex.
Example Sentences:
(1) In fact, it soon became clear that if there was anything designed to get Tony really riled, it was talk of God.
(2) We are Protestant Christians, so by sending monks to chant sutras they were trying to get us riled up,” a member of one Zhejiang church told Radio Free Asia , a US-funded news website.
(3) Gui Minhai: the strange disappearance of a publisher who riled China's elite Read more Five Hong Kong booksellers – Gui Minhai, Lee Bo, Lui Bo, Cheung Ji-ping and Lam Wing-kei – who specialised in books criticising China’s Communist party elite have vanished since October.
(4) Francesco Totti has escaped with a spell on the naughty step for goading Lazio fans in the wake of Sunday's Rome derby, but has been fined €10,000 for each thumb he pointed down in a bid to rile them up.
(5) Golly; so riled is Abrams that he has committed a Hollywood solecism – you never tell anyone not to come.
(6) How Spurs craved someone similarly streetwise 7 Tottenham Hotspur Hugo Lloris Wrongfooted by deflections for both Chelsea goals, with the reality he did well to deny Cahill and Fàbregas scant consolation 6 Kyle Walker Eager to push on down the flank but exposed by Hazard’s slippery running and not tight enough to Costa at Chelsea’s second 5 Chelsea old guard triumph but Spurs academy talent point to future | David Hytner Read more Eric Dier Riled by Costa from the moment they clashed five minutes in.
(7) How it must rile politicians that, while only 18% of the public believe them to tell the truth , and just 34% of us believe business leaders, trade union officials are trusted by 41%.
(8) The benefits system is due for review again in 2013, with the prospect of another round of strikes if the government riles performers and technicians.
(9) George Osborne has riled his Liberal Democrat colleagues by trying to take the credit for the increase (so far) in the starting point for income tax from £6,475 to £10,000, a notably popular policy that has lifted about 2 million people out of income tax altogether.
(10) He made his points firmly, but was careful to avoid sounding riled.
(11) For socialists, taxation has a moral element and the suspicion the wealthy were “getting away with it” riled my father in a way it did not a pragmatic one-nation Tory like me.
(12) Instead, what often counts in politics is the spectacle of people being riled by this or that example of clumsy tinkering, particularly if any proposed change has some symbolic resonance.
(13) The couple's definition of success has riled some readers, revolving, as it does, around the bald data of income and education levels.
(14) But it never dared to, for fear that Hamdan's risqué music would rile Mubarak-era authorities.
(15) Varoufakis, the academic-turned-politician who has riled his eurozone counterparts, said he would not remain finance minister on Monday if Greece voted yes.
(16) But just try not to retaliate too aggressively or get too riled … Like I've said before: On the whole people are 'good', lets concentrate on that."
(17) Her presence at the parade – while an obvious indication of the political reconciliation she is attempting to achieve – is sure to rile supporters and critics, many of whom question her political integrity and increasing closeness with a group that quashed dissent for nearly 50 years and has been accused of committing genocide against ethnic Rohingya Muslims.
(18) Hayward, who riled Barack Obama by saying the amount of crude tipped into the Gulf of Mexico since the 20 April explosion was relatively "tiny" and that he "wanted his life back", even though 11 people died in the explosion, will be replaced by Bob Dudley , a BP veteran who is currently overseeing the clean-up of the oil spill.
(19) And she believes the distinctive paint job is a provocative gesture that has riled neighbours.
(20) Pellegrini, riled by Mourinho's dash across his box, hardly offered a vote of confidence in his later mumbled assessment.