(n.) A young or inferior devil; a little, malignant spirit; a puny demon; a contemptible evil worker.
(n.) Something added to, or united with, another, to lengthen it out or repair it, -- as, an addition to a beehive; a feather inserted in a broken wing of a bird; a length of twisted hair in a fishing line.
(n.) To graft; to insert as a scion.
(n.) To graft with new feathers, as a wing; to splice a broken feather. Hence, Fig.: To repair; to extend; to increase; to strengthen to equip.
Example Sentences:
(1) Intramembrane particles (IMP) were quantitatively assessed in the perikaryal plasma membranes of infundibular neurons.
(2) The inhibition by TAD of IMP DH activity in ovarian carcinomas (N = 4) was 81%.
(3) Incubation of I diaphragms with isoproterenol did not significantly increase the concentrations of AMP, IMP or inorganic phosphate, activators of phosphorylase beta activity, nor was there a decrease in ATP and glucose 6-phosphate content, allosteric inhibitors of phosphorylase beta activity.
(4) Second, interconversion of adenine nucleotides to guanine nucleotides, is curtailed by the inhibition of IMP dehydrogenase by these same IMP analogues.
(5) Under optimal reaction conditions, HhaI and RsaI cleaved the DMTS-std duplex to 76-77% completion and the DMTS-imp duplex to 96-99% completion.
(6) The incorporation of inosine or hypoxanthine into the IMP and ITP has been proved.
(7) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(8) It was concluded that the IMP content of human skeletal muscle is very low at rest and after low-intensity exercise, but increases after moderate and high-intensity exercise.
(9) The synthetic "C" nucleoside, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), its selenium analogue selenazofurin, and the related inhibitor of inosine 5'-phosphate (IMP) dehydrogenase, mycophenolic acid, are effective inducers of the terminal differentiation of HL-60 promyelocytic leukemia cells.
(10) After 60 min recovery, exercise was performed for 8-10 min each at 20, 30, 40 and 50 W. Measurements of pulmonary oxygen uptake, heart rate, blood pressure, leg blood flow, and femoral arterial-venous differences of oxygen content and lactate were performed as well as determination of ATP, creatine phosphate (CP) inosine monophosphate (IMP) and lactate concentrations on biopsy material from the quadriceps muscle before and immediately after the intense exercise, and at 3, 10 and 60 min into recovery.
(11) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(12) Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP.
(13) Uptake of IMP was calculated from the arteriovenous difference of 14C-IMP across the lung and lung effluents and homogenates were analyzed for the presence of metabolites of IMP.
(14) During continuous isometric exercise with constant stimulation time, the amount of IMP was linearly and inversely related to the age of the animals; a higher IMP concentration was found in intermittent isometric and dynamic exercise.
(15) We evaluated the effect of high partial pressures of O2 on pulmonary uptake and metabolism of IMP.
(16) Thus, 123I-IMP and 99mTc-HM-PAO SPECTs seemed to be a useful tool in the diagnosis, deciding of whether the treatment was suspended or continued, and clarifying the pathophysiology in HSE.
(17) It was considered that the analysis of the lung release of 123I-IMP forms a new lung dysfunction index.
(18) The increased activity in cancer cells of inosine 5'-monophosphate dehydrogenase (IMP DH, EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, was suggested as a sensitive target for chemotherapy.
(19) To determine the biochemical mechanisms of cytotoxicity of these drugs, assay procedures have been developed for measurement of the levels of intermediates proximal to IMP in the pathway for de novo purine biosynthesis in mouse L1210 leukemia cells.
(20) Our review indicates that 123I-IMP SPECT may have an important future role in the early diagnosis and management of patients with acute infarctive stroke and AD.
Scion
Definition:
(n.) A shoot or sprout of a plant; a sucker.
(n.) A piece of a slender branch or twig cut for grafting.
(n.) Hence, a descendant; an heir; as, a scion of a royal stock.
Example Sentences:
(1) It was at this time that Milosevic forged a close friendship with Stambolic, scion of an elite communist family.
(2) State they’re in This was the season American MBNA credit-card scion Randy Lerner finally announced his Villa venture was over and he wanted to sell.
(3) Congress party strategists say that their campaign leader Rahul Gandhi 's relative youth – the scion of the Nehru-Gandhi dynasty is 43 – and their tradition of "pluralist secularism" will win over young people.
(4) Ineffectively led by the family scion Rahul, the party that won India its independence was comprehensively swept aside by Modi’s Bharatiya Janata party.
(5) Hall might be a scion of one of Britain's most important theatrical dynasties (his father is Peter, his half-sister Rebecca), but the cocky irreverence of his productions showed he had every intention of making his own mark.
(6) Two “prominent” Republicans told the New York Times that the scions of the respective affluent and well-connected white families will meet privately in Utah this week, not long before a Wall Street Journal reporter caught Bush at an airport gate for a flight headed to Salt Lake City, near where the Romney family keeps one of its largest houses .
(7) The judicial body confirmed establishing an indirect link with the elder Gaddafi scion, who is believed to be in southern Libya where he is attempting to reach either Niger or Mali.
(8) If it seems eccentric to compare Churchill, scion of the Dukes of Marlborough, with Davis, who was brought up in a council flat in south London, then factor in their shared attributes: unshakable self-confidence, a certain vanity, and a capacity to inspire affection and extreme irritation.
(9) Here, Visconti was doubly lucky; not only was he adapting a novel by Di Lampedusa, melancholic scion of a dwindled dynasty much like the one in The Leopard , but he himself – Luchino Visconti di Madrone, Count of Lonate Pozzolo – was himself such a figure, the playboy descendent of a powerful feudal family that had controlled Milan and Pisa before the Renaissance.
(10) It is particularly noteworthy that overrepresented in this list of political scions are southern Democrats , most of whom are also women.
(11) Unveiling his party's manifesto for elections beginning 7 April, Rahul Gandhi, the scion of the country's most famous political dynasty and the face of the Congress campaign for re-election , said $1tn (£600bn) would be spent on India's inadequate infrastructure and a universal pension scheme created if his party was returned to power.
(12) He mixed with an international circle of acquaintances, including politicians and scions of industry.
(13) John Gotti Junior, scion of the famous Gambino Mafia family, will walk into a Manhattan courtroom.
(14) But New England is overflowing with enough dynastic ambition right now to make even scions of the gilded age blush.
(15) He was born with, if not a silver spoon, then at least a silver-plated spoon in his mouth, being a scion on his father's side of the Kennedy earldom which used to own Culzean Castle in Scotland, and on his mother's side of a Scottish baronetcy.
(16) Money, connections and media attention can be a gift for a young scion seeking to outshine his or her famous parent, but they can also be a curse and some, like Jones, go to great lengths to avoid them.
(17) • Athinas Street, Mon-Sat 8am-6pm Nikos Hadjikyriakos-Ghika Gallery One of Greece’s most important 20th-century artists, Nikos Ghika was also a seriously minted scion of an aristocratic family (and a Rothschild by marriage) with exquisite taste in mid-century modern design.
(18) In controversial comments likely to cause a storm in India, Gandhi – considered a likely prime ministerial candidate and a scion of the country's leading political family – warned Timothy Roemer that although "there was evidence of some support for [Islamic terrorist group Laskar-e-Taiba] among certain elements in India's indigenous Muslim community, the bigger threat may be the growth of radicalised Hindu groups, which create religious tensions and political confrontations with the Muslim community ".
(19) The concept was exported to the US by Rorion Gracie, grandmaster of jiu jitsu , scion of one of the most famous fighting families in the world, and, as a 1989 article in Playboy put it, “the toughest man in the United States”.
(20) In the ensuing years – during which Hirsch was greeted by the American right as a prophet and a saviour, and by the left as a scion of the empire of evil – these ideas solidified.