(n.) Freedom from that which pains, or harasses, as toil, care, grief, etc.
(n.) The quality or condition of being indolent; inaction, or want of exertion of body or mind, proceeding from love of ease or aversion to toil; habitual idleness; indisposition to labor; laziness; sloth; inactivity.
Example Sentences:
(1) The rate of indole production is increased about 4-fold when the aminoacrylate produced is converted to S-(hydroxyethyl)-L-cysteine by a coupled beta-replacement reaction with beta-mercaptoethanol.
(2) This derivative also allowed sensitive detection and measurement of indole-3-pyruvate in the picogram range using a gas chromatograph with an electron capture detector.
(3) In addition, it has excellent antibacterial activity against indole-positive Proteus strains against which conventional Cephalosporins are ineffective.
(4) These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes.
(5) Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal.
(6) Among the indoles tested only 6-chloromelatonin, melatonin and N-acetylserotonin had significant affinities to the [125I]iodomelatonin binding site.
(7) Using thin layer chromatography on fluorescent silica gel plates, 5 indoles were identified and 6 unknown substances isolated from the pineal incubate and from both extracts.
(8) It was also found that the levels of s-dTK in the progressive stage were much higher than those in the indolent stage.
(9) Cyclobutadipyrimidines (pyrimidine dimers) undergo splitting that is photosensitized by indole derivatives.
(10) This series of compounds includes [R-(R*,R*)]-4-[[2-[[3-(1H-indol-3-yl)-2-methyl-1-oxo-2- [[(tricyclo[3.3.1.1] dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]- 4-oxobutanoic acid (CI-988, 1, Figure 1), the first rationally designed non-peptide antagonist of a neuropeptide receptor.
(11) Eight of the nine (88.9%) Proteus vulgaris isolates gave a positive spot indole test; one (11.1%) gave a negative result.
(12) 15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and EO9 (3-hydroxymethyl-5-aziridinyl-1-methyl-2-(IH-indole-4,7-dione)prop-beta- en-alpha-ol).
(13) The fluorogenic beta-D-Glucuronidase test, together with an Indol-capillary test for rapid identification of E. coli, were proved with 60 toxinogenic, 335 nontoxinogenic wild-type strains, and 87 other gram-negative isolates from food.
(14) Enzymatic production of L-tryptophan from DL-serine and indole by a coupled reaction of tryptophan synthase and amino acid racemase was studied.
(15) It inhibited some Enterobacter and indole-positive Proteus, but it was less active against these later species than was cefamandole, cefuroxime, or cefoxitin.
(16) An hydroxyl group in the 5 position of the indole nucleus, sterically unencumbered by hydroxyls in neighboing positions, is essential.
(17) We now report a second case with similar features of chronic recurrent indolent inflammatory skin lesions, nondiagnostic skin biopsies, and failure to respond to antibiotics.
(18) In this study, the roots of Tabernaemontana heyneana Wall were examined and the isolation and identification of additional indole alkaloids and some pharmacological properties of coronaridine are described.
(19) In an effort to understand the mechanism by which dietary indoles inhibit chemically initiated tumorigenesis in experimental animals, we have investigated the potency of 3-substituted and 1,3-disubstituted indoles on the induction of intestinal and hepatic cytochrome P-448-dependent monooxygenases in the rat.
(20) Low nanogram levels of tyrosine, norepinephrine, 5-hydroxyindole-3-acetic acid, tryptophan, serotonin and 6-hydroxymelatonin, and picogram levels of 5-hydroxytryptophan, 5-hydroxytryptophol, 5-methoxyindole-3-acetic acid, indole 3-acetic acid, 5-methoxytryptophol and melatonin were indicated in most of the samples.
Torpor
Definition:
(n.) Loss of motion, or of the motion; a state of inactivity with partial or total insensibility; numbness.
(n.) Dullness; sluggishness; inactivity; as, a torpor of the mental faculties.
Example Sentences:
(1) After arousal from torpor, within 2 h dendrites completely restored their structure.
(2) Bats have maximum life spans a minimum of 3 times those of nonflying eutherians--a trend resulting from neither low basal metabolic rate, the ability to enter torpor, nor large relative brain size.
(3) Three years of frustration at the torpor he found at the centre of the party spills out.
(4) Experiments with temperature and torpor and castration did not alter the annual did not alter the rhythm...
(5) Dietary lipids strongly influence the pattern of torpor and the body lipid composition of mammalian hibernators.
(6) Testosterone and 5 alpha-dihydrotestosterone administration totally inhibited daily torpor in hamsters which were exposed to short days.
(7) At 10 wk of age, group-housed glutamate-obese mice exhibited nocturnal and early diurnal torpor, i.e., they thermoregulated at a lower than normal body temperature.
(8) Estradiol inhibited torpor to a greater extent in intact and ovariectomized female hamsters hibernating in long days than those in short days, suggesting an effect of photoperiod on responsiveness to estradiol.
(9) Selective feeding and incorporation of high amounts of unsaturated fatty acids into tissues and cell membranes may be an important preparation for hibernation of E. amoenus which lowers its body temperature during torpor to about 0 degrees C.
(10) Like many mammalian heterotherms, the big brown bat, Eptesicus fuscus, breathes intermittently during torpor.
(11) Just as Everton’s bid to snap out of their torpor was gaining momentum, however, it was curtailed by a third United goal that killed the contest.
(12) Water independence is achieved through efficient renal function while low rates of energy usage and torpor are further effective in reducing overall water requirements.
(13) The object of the present study was to investigate whether these diet-induced physiological and biochemical changes also occur in species that show shallow, daily torpor.
(14) Nevertheless, decreased testosterone secretion alone is not a sufficient condition for induction of daily torpor, since torpor was rarely observed in hamsters exposed to long days, even after castration.
(15) Hormone levels were generally lower in hibernators sampled during bouts of torpor than during bouts of spontaneous arousal from torpor.
(16) It is concluded that there is an inverse temperature effect that minimizes fuel usage during torpor.
(17) In addition, carbohydrate levels are significantly lower, whereas fatty acid and ketone levels are significantly higher during torpor.
(18) After the last (terminal) arousal from torpor, T levels were moderately elevated for 4 wk and maximal for the next 6 wk before they returned to basal values.
(19) The durations of the intervals of torpor and euthermia during mammalian hibernation were found to be dependent on body mass.
(20) Castration influenced certain aspects of the daily torpor display.