(n.) Freedom from that which pains, or harasses, as toil, care, grief, etc.
(n.) The quality or condition of being indolent; inaction, or want of exertion of body or mind, proceeding from love of ease or aversion to toil; habitual idleness; indisposition to labor; laziness; sloth; inactivity.
Example Sentences:
(1) The rate of indole production is increased about 4-fold when the aminoacrylate produced is converted to S-(hydroxyethyl)-L-cysteine by a coupled beta-replacement reaction with beta-mercaptoethanol.
(2) This derivative also allowed sensitive detection and measurement of indole-3-pyruvate in the picogram range using a gas chromatograph with an electron capture detector.
(3) In addition, it has excellent antibacterial activity against indole-positive Proteus strains against which conventional Cephalosporins are ineffective.
(4) These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes.
(5) Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal.
(6) Among the indoles tested only 6-chloromelatonin, melatonin and N-acetylserotonin had significant affinities to the [125I]iodomelatonin binding site.
(7) Using thin layer chromatography on fluorescent silica gel plates, 5 indoles were identified and 6 unknown substances isolated from the pineal incubate and from both extracts.
(8) It was also found that the levels of s-dTK in the progressive stage were much higher than those in the indolent stage.
(9) Cyclobutadipyrimidines (pyrimidine dimers) undergo splitting that is photosensitized by indole derivatives.
(10) This series of compounds includes [R-(R*,R*)]-4-[[2-[[3-(1H-indol-3-yl)-2-methyl-1-oxo-2- [[(tricyclo[3.3.1.1] dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]- 4-oxobutanoic acid (CI-988, 1, Figure 1), the first rationally designed non-peptide antagonist of a neuropeptide receptor.
(11) Eight of the nine (88.9%) Proteus vulgaris isolates gave a positive spot indole test; one (11.1%) gave a negative result.
(12) 15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and EO9 (3-hydroxymethyl-5-aziridinyl-1-methyl-2-(IH-indole-4,7-dione)prop-beta- en-alpha-ol).
(13) The fluorogenic beta-D-Glucuronidase test, together with an Indol-capillary test for rapid identification of E. coli, were proved with 60 toxinogenic, 335 nontoxinogenic wild-type strains, and 87 other gram-negative isolates from food.
(14) Enzymatic production of L-tryptophan from DL-serine and indole by a coupled reaction of tryptophan synthase and amino acid racemase was studied.
(15) It inhibited some Enterobacter and indole-positive Proteus, but it was less active against these later species than was cefamandole, cefuroxime, or cefoxitin.
(16) An hydroxyl group in the 5 position of the indole nucleus, sterically unencumbered by hydroxyls in neighboing positions, is essential.
(17) We now report a second case with similar features of chronic recurrent indolent inflammatory skin lesions, nondiagnostic skin biopsies, and failure to respond to antibiotics.
(18) In this study, the roots of Tabernaemontana heyneana Wall were examined and the isolation and identification of additional indole alkaloids and some pharmacological properties of coronaridine are described.
(19) In an effort to understand the mechanism by which dietary indoles inhibit chemically initiated tumorigenesis in experimental animals, we have investigated the potency of 3-substituted and 1,3-disubstituted indoles on the induction of intestinal and hepatic cytochrome P-448-dependent monooxygenases in the rat.
(20) Low nanogram levels of tyrosine, norepinephrine, 5-hydroxyindole-3-acetic acid, tryptophan, serotonin and 6-hydroxymelatonin, and picogram levels of 5-hydroxytryptophan, 5-hydroxytryptophol, 5-methoxyindole-3-acetic acid, indole 3-acetic acid, 5-methoxytryptophol and melatonin were indicated in most of the samples.
Woe
Definition:
(n.) A curse; a malediction.
(a.) Woeful; sorrowful.
(n.) Grief; sorrow; misery; heavy calamity.
Example Sentences:
(1) The disappointing weather at Easter left beaches deserted but some Britons, who were determined to enjoy the outdoors this time round, have already had their plans thwarted by the weather, taking to websites such as ukcampsite.co.uk to swap tales of woe, such as farmers calling to cancel bookings because sites were waterlogged.
(2) If I’m the bad guy because I’m not the guy they want me to be, then so be it.” Over the last year he resolved his promotional woes in court and has since signed with Jay Z’s Roc Nation Sports – along with Miguel Cotto the nascent sports agency’s highest-profile signing in boxing.
(3) While Chinese media have not spelt out Zhou's woes explicitly, the hints have grown more blatant by the month, with some identifying him via his family relationships.
(4) Asked if Aamer would talk publicly about his experiences, Crider said: “I think he will make up his own mind about it, and really, woe betide the person who tries to silence Shaker Aamer.” She added that it would be up to him “how much of his story and the terrible things he witnessed that he wants to tell”.
(5) Plummeting oil prices only added to economic woes in a country with the world’s fourth-largest oil reserves.
(6) To add to their woes, the cost of their dollar-denominated debt is rising; the US Federal Reserve said December’s rate hike is just the start of a “gradual” tightening cycle .
(7) It’s a seismic moment for the industry and particularly the big European manufacturers who have done a lot of work on diesel: technologically, they have they made the wrong bet.” Some analysts believe fears of brand damage in Europe are overstated but Bailey says: “In the US it’s very different: VW have killed their diesel market and it has left them in a very difficult position.” For British manufacturer Jaguar Land Rover, the timing of VW’s woes was ominous, as it unveiled two new diesels in America.
(8) The aluminium magnate's British-related woes do not stop there: a former business partner, Michael Cherney, is suing him for $4bn in the high court.
(9) We have to acknowledge that it's extremely hard to build a regular city from scratch.” Furthermore, some experts say that certified green buildings and pedestrian-friendly roads are a worthless patch for China’s environmental woes, not a solution.
(10) The woes of British industry were echoed right across Europe in November, as firms slashed production amid plunging demand from consumers in all the world's major markets.
(11) Clinton said her woes over her email server had been a “drip, drip, drip” that was impacting her.
(12) In an otherwise assured performance on Sunday’s Andrew Marr Show , Douglas Alexander – when urged to address Ed Miliband’s woes – resorted to the words of Harold Wilson.
(13) Buhari has presented himself as a born-again democrat who possesses the experience to steer the country through instability, currency woes and rampant corruption.
(14) Creative diplomacy is still much required in the Middle East, where it is hard to see how a dominantly military strategy against Islamic State can in itself, and even over time, bring a solution to the region’s woes.
(15) The unrest over rising petrol prices is only further adding to Nigeria's security woes: Jonathan already declared a state of emergency over the weekend in parts of the country hit by a growing Islamic insurgency that is fuelled in part by widespread poverty.
(16) But that may be the least of Ukip’s woes as it sups the bitter draught of victory.
(17) 7.31pm BST Nick Kyrgios's legs have gone to jelly and his heart is full of woe.
(18) It is not the cause of Spain's economic woes, but think of this: if everybody paid their dues, Spain's deficit would be zero.
(19) The result in some richer countries has been a political movement that blames globalisation for all woes and seeks somehow to wall off the economy from global trends rather than engage cooperatively with foreign nations.
(20) Probably... April 23, 2013 11.42am BST Analysts see little relief for Europe The continuing fall in Eurozone output this month ( see 9.19am ) led by Germany's shrinking private sector seconomy, shows that there's no improvement in Europe's woes.