(a.) Indulging in ease; avoiding labor and exertion; habitually idle; lazy; inactive; as, an indolent man.
(a.) Causing little or no pain or annoyance; as, an indolent tumor.
Example Sentences:
(1) The rate of indole production is increased about 4-fold when the aminoacrylate produced is converted to S-(hydroxyethyl)-L-cysteine by a coupled beta-replacement reaction with beta-mercaptoethanol.
(2) This derivative also allowed sensitive detection and measurement of indole-3-pyruvate in the picogram range using a gas chromatograph with an electron capture detector.
(3) In addition, it has excellent antibacterial activity against indole-positive Proteus strains against which conventional Cephalosporins are ineffective.
(4) These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes.
(5) Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal.
(6) Among the indoles tested only 6-chloromelatonin, melatonin and N-acetylserotonin had significant affinities to the [125I]iodomelatonin binding site.
(7) Using thin layer chromatography on fluorescent silica gel plates, 5 indoles were identified and 6 unknown substances isolated from the pineal incubate and from both extracts.
(8) It was also found that the levels of s-dTK in the progressive stage were much higher than those in the indolent stage.
(9) Cyclobutadipyrimidines (pyrimidine dimers) undergo splitting that is photosensitized by indole derivatives.
(10) This series of compounds includes [R-(R*,R*)]-4-[[2-[[3-(1H-indol-3-yl)-2-methyl-1-oxo-2- [[(tricyclo[3.3.1.1] dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]- 4-oxobutanoic acid (CI-988, 1, Figure 1), the first rationally designed non-peptide antagonist of a neuropeptide receptor.
(11) Eight of the nine (88.9%) Proteus vulgaris isolates gave a positive spot indole test; one (11.1%) gave a negative result.
(12) 15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and EO9 (3-hydroxymethyl-5-aziridinyl-1-methyl-2-(IH-indole-4,7-dione)prop-beta- en-alpha-ol).
(13) The fluorogenic beta-D-Glucuronidase test, together with an Indol-capillary test for rapid identification of E. coli, were proved with 60 toxinogenic, 335 nontoxinogenic wild-type strains, and 87 other gram-negative isolates from food.
(14) Enzymatic production of L-tryptophan from DL-serine and indole by a coupled reaction of tryptophan synthase and amino acid racemase was studied.
(15) It inhibited some Enterobacter and indole-positive Proteus, but it was less active against these later species than was cefamandole, cefuroxime, or cefoxitin.
(16) An hydroxyl group in the 5 position of the indole nucleus, sterically unencumbered by hydroxyls in neighboing positions, is essential.
(17) We now report a second case with similar features of chronic recurrent indolent inflammatory skin lesions, nondiagnostic skin biopsies, and failure to respond to antibiotics.
(18) In this study, the roots of Tabernaemontana heyneana Wall were examined and the isolation and identification of additional indole alkaloids and some pharmacological properties of coronaridine are described.
(19) In an effort to understand the mechanism by which dietary indoles inhibit chemically initiated tumorigenesis in experimental animals, we have investigated the potency of 3-substituted and 1,3-disubstituted indoles on the induction of intestinal and hepatic cytochrome P-448-dependent monooxygenases in the rat.
(20) Low nanogram levels of tyrosine, norepinephrine, 5-hydroxyindole-3-acetic acid, tryptophan, serotonin and 6-hydroxymelatonin, and picogram levels of 5-hydroxytryptophan, 5-hydroxytryptophol, 5-methoxyindole-3-acetic acid, indole 3-acetic acid, 5-methoxytryptophol and melatonin were indicated in most of the samples.
Insolent
Definition:
(a.) Deviating from that which is customary; novel; strange; unusual.
(a.) Haughty and contemptuous or brutal in behavior or language; overbearing; domineering; grossly rude or disrespectful; saucy; as, an insolent master; an insolent servant.
(a.) Proceeding from or characterized by insolence; insulting; as, insolent words or behavior.
Example Sentences:
(1) 50 runners with exertion induced injuries of the lower extremity were provided with appropriate running shoe insoles.
(2) And a woman in front of me said: “They are calling for Fox.” I didn’t know which booth to go to, then suddenly there was a man in front of me, heaving with weaponry, standing with his legs apart yelling: “No, not there, here!” I apologised politely and said I’d been buried in my book and he said: “What do you expect me to do, stand here while you finish it?” – very loudly and with shocking insolence.
(3) Subjects used these insoles during dance class for 15 weeks.
(4) Based on clinical and biomechanical peculiarities of foot, in the institute have been developed insertable orthopaedic devices for mass-produced footwear for mentioned pathology: corrective device with unloading element and curative insole.
(5) Young people now may hardly know her, and it is hard today to conjure up the sexiness, the daring, the insolence of some women on screen in the 50s when the Production Code still prevailed.
(6) The author discusses the use of accommodative weight-dispersing insoles as an alternative to surgical excision for the treatment of such lesions.
(7) Controlled rigidity is provided by the incorporation of a spring steel shank between the sponge insole and the hard wearing plastic sole.
(8) I was told it was a contractual requirement, despite there being no mention of either the strike system or the obligation to sell insoles within the contract itself.
(9) Therefore running shoe insoles can eliminate peak forces by exactly placing supporting elements.
(10) Treat with orthotic insoles or look at upping your shoe size.
(11) This paper describes a study of the effectiveness of commercially available shock absorbing insoles when used in four different pairs of shoes during normal walking.
(12) Insoles will be available to turn any existing shoes into smartshoes.
(13) A new method was developed for the quality testing of shoes, insoles and sport shoes.
(14) The purposes of this study were: 1) to compare the impact forces in running using running shoes with conventional insoles to the impact forces using running shoes with four different viscoelastic insoles, 2) to discuss possible effects of the viscoelastic insoles on lower leg kinematics, and 3) to explain the force and kinematic results using a mechanical model.
(15) A full account is given of (a) Wilhelm Werneck's therapeutic coagulations (1835): rupturing of cataract by focussed light (sun, phosphorus); (b) Maximilian Adolf Langenbeck's "insolation" of corneal, pupillary and retinal lesions and of traumatic cataract (1859); (c) Vinzenz Czerny's coagulation experiments on the retina of various animals (1867, 1882).
(16) Vertical foot bearing pressure was decreased by an average of 18% by wearing shoes padded with a Professional Protective Technology insole and the decrease was greater in patients with higher foot pressure.
(17) About a third of dancers fitted with viscoelastic insoles and a tenth of placebo insert wearers found that the insoles made their shoes too tight to be comfortable.
(18) Without physical exercise and direct insolation death usually occurred later (on the average of 5-9 days) from acute renal and renal-hepatic failure.
(19) The mechanism of the static effects of the wedged insole for the medial osteoarthritic knee was studied in ten women.
(20) The most important finding was that an elastic polymer insole with good shock absorbency properties did not prevent stress reactions of bone during a 12-week period of vigorous physical training.