(a.) Indulging in ease; avoiding labor and exertion; habitually idle; lazy; inactive; as, an indolent man.
(a.) Causing little or no pain or annoyance; as, an indolent tumor.
Example Sentences:
(1) The rate of indole production is increased about 4-fold when the aminoacrylate produced is converted to S-(hydroxyethyl)-L-cysteine by a coupled beta-replacement reaction with beta-mercaptoethanol.
(2) This derivative also allowed sensitive detection and measurement of indole-3-pyruvate in the picogram range using a gas chromatograph with an electron capture detector.
(3) In addition, it has excellent antibacterial activity against indole-positive Proteus strains against which conventional Cephalosporins are ineffective.
(4) These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes.
(5) Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal.
(6) Among the indoles tested only 6-chloromelatonin, melatonin and N-acetylserotonin had significant affinities to the [125I]iodomelatonin binding site.
(7) Using thin layer chromatography on fluorescent silica gel plates, 5 indoles were identified and 6 unknown substances isolated from the pineal incubate and from both extracts.
(8) It was also found that the levels of s-dTK in the progressive stage were much higher than those in the indolent stage.
(9) Cyclobutadipyrimidines (pyrimidine dimers) undergo splitting that is photosensitized by indole derivatives.
(10) This series of compounds includes [R-(R*,R*)]-4-[[2-[[3-(1H-indol-3-yl)-2-methyl-1-oxo-2- [[(tricyclo[3.3.1.1] dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]- 4-oxobutanoic acid (CI-988, 1, Figure 1), the first rationally designed non-peptide antagonist of a neuropeptide receptor.
(11) Eight of the nine (88.9%) Proteus vulgaris isolates gave a positive spot indole test; one (11.1%) gave a negative result.
(12) 15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and EO9 (3-hydroxymethyl-5-aziridinyl-1-methyl-2-(IH-indole-4,7-dione)prop-beta- en-alpha-ol).
(13) The fluorogenic beta-D-Glucuronidase test, together with an Indol-capillary test for rapid identification of E. coli, were proved with 60 toxinogenic, 335 nontoxinogenic wild-type strains, and 87 other gram-negative isolates from food.
(14) Enzymatic production of L-tryptophan from DL-serine and indole by a coupled reaction of tryptophan synthase and amino acid racemase was studied.
(15) It inhibited some Enterobacter and indole-positive Proteus, but it was less active against these later species than was cefamandole, cefuroxime, or cefoxitin.
(16) An hydroxyl group in the 5 position of the indole nucleus, sterically unencumbered by hydroxyls in neighboing positions, is essential.
(17) We now report a second case with similar features of chronic recurrent indolent inflammatory skin lesions, nondiagnostic skin biopsies, and failure to respond to antibiotics.
(18) In this study, the roots of Tabernaemontana heyneana Wall were examined and the isolation and identification of additional indole alkaloids and some pharmacological properties of coronaridine are described.
(19) In an effort to understand the mechanism by which dietary indoles inhibit chemically initiated tumorigenesis in experimental animals, we have investigated the potency of 3-substituted and 1,3-disubstituted indoles on the induction of intestinal and hepatic cytochrome P-448-dependent monooxygenases in the rat.
(20) Low nanogram levels of tyrosine, norepinephrine, 5-hydroxyindole-3-acetic acid, tryptophan, serotonin and 6-hydroxymelatonin, and picogram levels of 5-hydroxytryptophan, 5-hydroxytryptophol, 5-methoxyindole-3-acetic acid, indole 3-acetic acid, 5-methoxytryptophol and melatonin were indicated in most of the samples.
Lackadaisical
Definition:
(a.) Affectedly pensive; languidly sentimental.
Example Sentences:
(1) But this is fairly typical of the flat-footed and lackadaisical attitude that we’ve seen from the outset.
(2) In this week's small-screen news, Alan Carr abandons his planned sitcom about dog walkers, blaming himself for being too lackadaisical to make it happen ; London Live, the Evening Standard's new London TV station, has bought up the hit YouTube sitcom All About the Mackenzies ; and Peep Show's imminent demise has been confirmed by Channel 4 head of comedy Phil Clarke .
(3) The prime minister, who has often been criticised for a lackadaisical approach to government, showed that he had learnt from his political hero Harold Macmillan when he wielded the No 10 carving knife in a manner rarely seen in recent years.
(4) The lack of robust incentives or sanctions from funders fosters a lackadaisical attitude among scientists, who must also bear some of the responsibility for the slow adoption of open access.
(5) • Markets reacted lackadaisically but there were some warnings in the financial world that this could be bad.
(6) They used to be lackadaisical but they got involved and found out that if you become part of a movement, you can change things.
(7) Jeb Bush backs brother's NSA surveillance program to keep America safe Read more In a speech that was sharply skeptical of Iran, demonstratively supportive of Israel and disdainful of a White House foreign policy that he characterized as lackadaisical and foolish, Bush covered everything from the legacy in Iraq and Israeli prime minister Binyamin Netanyahu’s controversial visit to Washington to surveillance reform and relations with Cuba.
(8) Though AIDS was expected to arrive in Brazil, complacent, unconcerned officials responded in a lackadaisical manner through the veil of an abstract, inappropriate, and ideological Western-oriented model.
(9) A Conservative peer and former cabinet minister has attacked the UK media's "lackadaisical" response to the US whistleblower Edward Snowden and called on "defenders of liberty" to speak out against invasion of personal freedoms by the intelligence services.
(10) The "world team" played lackadaisical football, letting passes slide through and melting away whenever Kadyrov, stocky and heavy on his feet, had the ball.
(11) It means that far too many young people are lackadaisical in the way they present themselves for work.” He continued: “Youth unemployment in our country is far too high, and it is in everyone’s interest to make sure that young people receive the very best education and training to improve this situation.” Let’s all applaud the suggestion that youth unemployment is a problem the young people have brought on themselves, that employers are sweating plasma trying to find a single candidate who doesn’t turn up to the interview four days late, in pyjamas, with crayons stuffed up their nose.
(12) They moved to their own unpredictable beat, so much so that I would not have put money on them still being with us today, so laidback was their attitude, so lackadaisical their work rate, so uninterested were they in press or promotion.
(13) While the company has run afoul of US law for its lackadaisical approach to questions of real estate ownership, it has in Cuba an opportunity to start fresh with a government newly open to American businesses.
(14) "I am very surprised at the way in which the press in Britain has been so lackadaisical and not seen that there are issues here of huge importance.
(15) She told the Guardian the official investigation had been at best a “lackadaisical” effort and at worst a “huge fabrication”.
(16) We want the company hosting these threats to be less lackadaisical and able to respond faster.
(17) She sounds lackadaisical, but while she describes herself as "calm and laid-back", she also says she will "fight and fight and fight to keep acting in my life.
(18) From there they both won King’s Scholarships to Eton where Johnson’s famously lackadaisical approach – he failed to prepare his speech – led them to lose the house debating competition.