(a.) Indulging in ease; avoiding labor and exertion; habitually idle; lazy; inactive; as, an indolent man.
(a.) Causing little or no pain or annoyance; as, an indolent tumor.
(1) The rate of indole production is increased about 4-fold when the aminoacrylate produced is converted to S-(hydroxyethyl)-L-cysteine by a coupled beta-replacement reaction with beta-mercaptoethanol.
(2) This derivative also allowed sensitive detection and measurement of indole-3-pyruvate in the picogram range using a gas chromatograph with an electron capture detector.
(3) In addition, it has excellent antibacterial activity against indole-positive Proteus strains against which conventional Cephalosporins are ineffective.
(4) These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes.
(5) Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal.
(6) Among the indoles tested only 6-chloromelatonin, melatonin and N-acetylserotonin had significant affinities to the [125I]iodomelatonin binding site.
(7) Using thin layer chromatography on fluorescent silica gel plates, 5 indoles were identified and 6 unknown substances isolated from the pineal incubate and from both extracts.
(8) It was also found that the levels of s-dTK in the progressive stage were much higher than those in the indolent stage.
(9) Cyclobutadipyrimidines (pyrimidine dimers) undergo splitting that is photosensitized by indole derivatives.
(10) This series of compounds includes [R-(R*,R*)]-4-[[2-[[3-(1H-indol-3-yl)-2-methyl-1-oxo-2- [[(tricyclo[18.104.22.168] dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]- 4-oxobutanoic acid (CI-988, 1, Figure 1), the first rationally designed non-peptide antagonist of a neuropeptide receptor.
(11) Eight of the nine (88.9%) Proteus vulgaris isolates gave a positive spot indole test; one (11.1%) gave a negative result.
(12) 15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and EO9 (3-hydroxymethyl-5-aziridinyl-1-methyl-2-(IH-indole-4,7-dione)prop-beta- en-alpha-ol).
(13) The fluorogenic beta-D-Glucuronidase test, together with an Indol-capillary test for rapid identification of E. coli, were proved with 60 toxinogenic, 335 nontoxinogenic wild-type strains, and 87 other gram-negative isolates from food.
(14) Enzymatic production of L-tryptophan from DL-serine and indole by a coupled reaction of tryptophan synthase and amino acid racemase was studied.
(15) It inhibited some Enterobacter and indole-positive Proteus, but it was less active against these later species than was cefamandole, cefuroxime, or cefoxitin.
(16) An hydroxyl group in the 5 position of the indole nucleus, sterically unencumbered by hydroxyls in neighboing positions, is essential.
(17) We now report a second case with similar features of chronic recurrent indolent inflammatory skin lesions, nondiagnostic skin biopsies, and failure to respond to antibiotics.
(18) In this study, the roots of Tabernaemontana heyneana Wall were examined and the isolation and identification of additional indole alkaloids and some pharmacological properties of coronaridine are described.
(19) In an effort to understand the mechanism by which dietary indoles inhibit chemically initiated tumorigenesis in experimental animals, we have investigated the potency of 3-substituted and 1,3-disubstituted indoles on the induction of intestinal and hepatic cytochrome P-448-dependent monooxygenases in the rat.
(20) Low nanogram levels of tyrosine, norepinephrine, 5-hydroxyindole-3-acetic acid, tryptophan, serotonin and 6-hydroxymelatonin, and picogram levels of 5-hydroxytryptophan, 5-hydroxytryptophol, 5-methoxyindole-3-acetic acid, indole 3-acetic acid, 5-methoxytryptophol and melatonin were indicated in most of the samples.
(a.) Slow; sluggish; backward.
(n.) One who lags; a loiterer.
(1) "Sticking your head in the sand might make you feel safer, but it's not going to protect you from the coming storm," Obama warned climate laggards then.
(2) Dentists can be divided into five adoption categories based upon their time of adoption of pit and fissure sealants: innovators, early adopters, early majority, late majority, and laggards.
(3) The unique value of Time Warner’s industry-leading businesses including its portfolio of networks and its film studio and television production business is only going to increase.” Claire Enders, founder of media research firm Enders Analysis, said: “Time Warner been a real laggard in stock market terms for a long time with a lot of great assets that can be plucked like a chicken.
(4) "In some ways, the more interesting announcement was the continuation of the iPhone 3GS, which is now available for free on contract with many carriers, and which now represents Apple's low-cost strategy for emerging markets and smartphone laggards.
(5) The percentage of total aberrations in root tips exposed to nimrod reached 54.39% at 250 ppm for 4 h, and 64.69% in root tips exposed to rubigan-4 at 250 ppm for 6 h. The types of numerical chromosomal aberrations produced by both fungicides included: binucleate cells, c-metaphases, sticky chromosomes, polyploid cells, and laggards.
(6) It omitted a target date for peaking emissions, which meant there was no clear way of getting to the 2C goal, and it did not propose any penalties for climate laggards.
(7) Some of these differences, between the leaders and the laggards, are likely to surface in the talks this week among the IMF's 188 member countries, as central banks fret about their "exit strategy" from the emergency policies they have used to try to stimulate demand since the Great Recession.
(8) DfID welcomed the NAO report and said it was prepared to take tough action on laggards.
(9) The EU today contains some of the world's best places for free expression, namely Finland, Netherlands, Denmark and Sweden, but also laggards, such as Italy, Hungary, Greece and Romania, who sit behind new and emerging global democracies.
(10) Perry said she was delighted that No 10 had decided to intervene on the issue and accused ISPs of being laggards in the debate.
(11) Leader to laggard summarises the history of the UK’s rail network.
(12) Microsporocytes from a population of F2 plants derived from these stocks displayed the following aberrations: varying frequencies of metaphase and anaphase laggards, 'stickiness' at anaphase I resulting in chromosome bridges from pole to pole, acentric fragments and a spontaneous translocation of the NOR on chromosome 6.
(13) Mouse L-cells were treated with bis-benzimidazole derivative (Hoechst 33258), caffeine and bleomycin in order to study genesis of laggards and micronuclei and formation of kinetochores as revealed by antikinetochore antibody staining.
(14) Andrew Goodwin, senior economic adviser to the Ernst & Young ITEM Club Manufacturing has gone from being the star performer of the recovery to being the laggard.
(15) "Being a laggard has never been very successful in terms of capturing the greater share of the value added for the economy … if you create a sustainable market, you will achieve cost savings and drive economic benefits in terms of tax income and job creation."
(16) This entails creating markets and incentives that reward those prepared to back the green economy and exclude the (largely US-based) industry laggards that spend so much of their time and money lobbying against climate action instead of innovating sustainable business products and services.
(17) "Let's lead the change, not be laggards at a game in which we can succeed."
(18) "Internet service providers with the exception of TalkTalk have been laggardly in this area.
(19) The relevant questions, then, are: how many laggards are out there, how badly do they trail the field and how much extra capital do they need to survive, say, a sovereign debt crisis?
(20) ... Dickens did much with Carlyle’s despairing insight into cash payment as the sole nexus between human beings The bloody dramas of political and economic laggards can seem remote from liberal-democratic Britain.