(a.) Indulging in ease; avoiding labor and exertion; habitually idle; lazy; inactive; as, an indolent man.
(a.) Causing little or no pain or annoyance; as, an indolent tumor.
Example Sentences:
(1) The rate of indole production is increased about 4-fold when the aminoacrylate produced is converted to S-(hydroxyethyl)-L-cysteine by a coupled beta-replacement reaction with beta-mercaptoethanol.
(2) This derivative also allowed sensitive detection and measurement of indole-3-pyruvate in the picogram range using a gas chromatograph with an electron capture detector.
(3) In addition, it has excellent antibacterial activity against indole-positive Proteus strains against which conventional Cephalosporins are ineffective.
(4) These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes.
(5) Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal.
(6) Among the indoles tested only 6-chloromelatonin, melatonin and N-acetylserotonin had significant affinities to the [125I]iodomelatonin binding site.
(7) Using thin layer chromatography on fluorescent silica gel plates, 5 indoles were identified and 6 unknown substances isolated from the pineal incubate and from both extracts.
(8) It was also found that the levels of s-dTK in the progressive stage were much higher than those in the indolent stage.
(9) Cyclobutadipyrimidines (pyrimidine dimers) undergo splitting that is photosensitized by indole derivatives.
(10) This series of compounds includes [R-(R*,R*)]-4-[[2-[[3-(1H-indol-3-yl)-2-methyl-1-oxo-2- [[(tricyclo[3.3.1.1] dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]- 4-oxobutanoic acid (CI-988, 1, Figure 1), the first rationally designed non-peptide antagonist of a neuropeptide receptor.
(11) Eight of the nine (88.9%) Proteus vulgaris isolates gave a positive spot indole test; one (11.1%) gave a negative result.
(12) 15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and EO9 (3-hydroxymethyl-5-aziridinyl-1-methyl-2-(IH-indole-4,7-dione)prop-beta- en-alpha-ol).
(13) The fluorogenic beta-D-Glucuronidase test, together with an Indol-capillary test for rapid identification of E. coli, were proved with 60 toxinogenic, 335 nontoxinogenic wild-type strains, and 87 other gram-negative isolates from food.
(14) Enzymatic production of L-tryptophan from DL-serine and indole by a coupled reaction of tryptophan synthase and amino acid racemase was studied.
(15) It inhibited some Enterobacter and indole-positive Proteus, but it was less active against these later species than was cefamandole, cefuroxime, or cefoxitin.
(16) An hydroxyl group in the 5 position of the indole nucleus, sterically unencumbered by hydroxyls in neighboing positions, is essential.
(17) We now report a second case with similar features of chronic recurrent indolent inflammatory skin lesions, nondiagnostic skin biopsies, and failure to respond to antibiotics.
(18) In this study, the roots of Tabernaemontana heyneana Wall were examined and the isolation and identification of additional indole alkaloids and some pharmacological properties of coronaridine are described.
(19) In an effort to understand the mechanism by which dietary indoles inhibit chemically initiated tumorigenesis in experimental animals, we have investigated the potency of 3-substituted and 1,3-disubstituted indoles on the induction of intestinal and hepatic cytochrome P-448-dependent monooxygenases in the rat.
(20) Low nanogram levels of tyrosine, norepinephrine, 5-hydroxyindole-3-acetic acid, tryptophan, serotonin and 6-hydroxymelatonin, and picogram levels of 5-hydroxytryptophan, 5-hydroxytryptophol, 5-methoxyindole-3-acetic acid, indole 3-acetic acid, 5-methoxytryptophol and melatonin were indicated in most of the samples.
Lassitude
Definition:
(n.) A condition of the body, or mind, when its voluntary functions are performed with difficulty, and only by a strong exertion of the will; languor; debility; weariness.
Example Sentences:
(1) Adverse effects are mostly those related to hormone withdrawal, namely, impotence, infertility, and lassitude.
(2) Consecutive man-of-the-match performances against Greece and Ivory Coast helped Colombia brush aside the lassitude that swamped the country’s World Cup preparations after injury to their talismanic striker Falcao .
(3) The emancipation of children, the anxieties sometimes caused by the age of the parents, the lack of interest which society has in the 50 years old woman, but which it very readily takes in the old woman, conjugal lassitude, the lack of comprehension of those around her, very often bring such women to the doctor, who should know not only how to palliate the oestrogen deficiency, and the organic disorders, but also show evidence of a certain psychological understanding.
(4) Twenty workers promptly developed symptoms (e.g., nausea, vomiting, abdominal discomfort, diarrhea, giddiness, lassitude, headache, cough, shortness of breath) that typically lasted a few hours but persisted 1-2 days in 7 cases.
(5) A 46-year-old man, presenting with headache, nausea, and lassitude, was diagnosed as having diabetes mellitus and hyponatremia, and admitted to Tohoku University Hospital.
(6) 24 out of 30 employees at the X-ray department in Molde were shown to have health problems related to their work, including symptoms relating to the eyes, the upper and lower respiratory tract, and headache and lassitude.
(7) Abdominal or rectal pain and lassitude were the other main symptoms.
(8) A Senate leadership aide at the time, stunned by what she considered White House lassitude, explained why even people inclined to help Obama would vote against the measure: Obama had decreed Guantánamo be closed without presenting lawmakers with a specific plan they could defend to skeptical constituents.
(9) To fall back into the lassitude of the last 12 years, to talk, to discuss, to debate but never act; to declare our will but not enforce it; to combine strong language with weak intentions, a worse outcome than never speaking at all.
(10) HVA levels correlated positively with social interest and total positive scores on the Nurses Observation Scale for Inpatient Evaluation (NOSIE-30) and negatively with lassitude and slowness of movements on the Comprehensive Psychopathological Rating Scale (CPRS).
(11) Lethal doses of enterotoxin of Clostridium welchii (perfringens) type A injected intravenously into young fowls caused immediate lassitude, with partial recovery, followed by death seven to 35 h after inoculation.
(12) We found clinical symptoms of fever, chills, headache, abdominal pain, disturbances in bowel function, nausea, vomiting, anorexia, and lassitude in the first two weeks more frequently when compared with the 3rd, 4th, 5th weeks of illness (p less than 0.001).
(13) She was admitted to our hospital for her gradual onset of fatigue, lassitude.
(14) Side effects including dizziness, headache, abdominal discomfort, nausea, vomiting, diarrhoea, lassitude, arthralgia, sleepiness, cramps and hot sensation were the complaints from 80% of adults and 40% of children.
(15) We only observed, for one or two days, lassitude, headache, drowsiness, nausea, epigastric pain or arthralgia-myalgia, always of weak or moderate intensity and for 1 or 2 days.
(16) A 46-year-old man experienced weakness, lassitude, and vague, aching abdominal pain in the right upper quadrant.
(17) By the end of the study, a statistically significant improvement in three subjective parameters, ie, lassitude, the ability to concentrate in school, and mood was reported by the girls who ingested iron compared with the controls.
(18) A 17-year old-male presented with a 6-week history of weight loss, lassitude and calf pains.
(19) Anorexia, lassitude and severe diarrhoea were seen in 14 of the infected sheep after 21-26 days.
(20) The concurrence of hypertension combined with hypokalemia and revealing subjective symptoms such as paresthesia, muscular weakness and lassitude can suggest this infrequent diagnosis.