(a.) Indulging in ease; avoiding labor and exertion; habitually idle; lazy; inactive; as, an indolent man.
(a.) Causing little or no pain or annoyance; as, an indolent tumor.
Example Sentences:
(1) The rate of indole production is increased about 4-fold when the aminoacrylate produced is converted to S-(hydroxyethyl)-L-cysteine by a coupled beta-replacement reaction with beta-mercaptoethanol.
(2) This derivative also allowed sensitive detection and measurement of indole-3-pyruvate in the picogram range using a gas chromatograph with an electron capture detector.
(3) In addition, it has excellent antibacterial activity against indole-positive Proteus strains against which conventional Cephalosporins are ineffective.
(4) These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes.
(5) Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal.
(6) Among the indoles tested only 6-chloromelatonin, melatonin and N-acetylserotonin had significant affinities to the [125I]iodomelatonin binding site.
(7) Using thin layer chromatography on fluorescent silica gel plates, 5 indoles were identified and 6 unknown substances isolated from the pineal incubate and from both extracts.
(8) It was also found that the levels of s-dTK in the progressive stage were much higher than those in the indolent stage.
(9) Cyclobutadipyrimidines (pyrimidine dimers) undergo splitting that is photosensitized by indole derivatives.
(10) This series of compounds includes [R-(R*,R*)]-4-[[2-[[3-(1H-indol-3-yl)-2-methyl-1-oxo-2- [[(tricyclo[3.3.1.1] dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]- 4-oxobutanoic acid (CI-988, 1, Figure 1), the first rationally designed non-peptide antagonist of a neuropeptide receptor.
(11) Eight of the nine (88.9%) Proteus vulgaris isolates gave a positive spot indole test; one (11.1%) gave a negative result.
(12) 15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and EO9 (3-hydroxymethyl-5-aziridinyl-1-methyl-2-(IH-indole-4,7-dione)prop-beta- en-alpha-ol).
(13) The fluorogenic beta-D-Glucuronidase test, together with an Indol-capillary test for rapid identification of E. coli, were proved with 60 toxinogenic, 335 nontoxinogenic wild-type strains, and 87 other gram-negative isolates from food.
(14) Enzymatic production of L-tryptophan from DL-serine and indole by a coupled reaction of tryptophan synthase and amino acid racemase was studied.
(15) It inhibited some Enterobacter and indole-positive Proteus, but it was less active against these later species than was cefamandole, cefuroxime, or cefoxitin.
(16) An hydroxyl group in the 5 position of the indole nucleus, sterically unencumbered by hydroxyls in neighboing positions, is essential.
(17) We now report a second case with similar features of chronic recurrent indolent inflammatory skin lesions, nondiagnostic skin biopsies, and failure to respond to antibiotics.
(18) In this study, the roots of Tabernaemontana heyneana Wall were examined and the isolation and identification of additional indole alkaloids and some pharmacological properties of coronaridine are described.
(19) In an effort to understand the mechanism by which dietary indoles inhibit chemically initiated tumorigenesis in experimental animals, we have investigated the potency of 3-substituted and 1,3-disubstituted indoles on the induction of intestinal and hepatic cytochrome P-448-dependent monooxygenases in the rat.
(20) Low nanogram levels of tyrosine, norepinephrine, 5-hydroxyindole-3-acetic acid, tryptophan, serotonin and 6-hydroxymelatonin, and picogram levels of 5-hydroxytryptophan, 5-hydroxytryptophol, 5-methoxyindole-3-acetic acid, indole 3-acetic acid, 5-methoxytryptophol and melatonin were indicated in most of the samples.
Lethargic
Definition:
(a.) Alt. of Lethargical
Example Sentences:
(1) Neurological examination revealed a lethargic man with good orientation to three spheres.
(2) These pigs also seemed more lethargic than controls and appeared sedated.
(3) On the other hand, the patient was noticed lethargic and showed parkinsonism i.e., rest tremor, cog-wheel rigidity, and hypokinesia.
(4) Physically, the patient appeared lethargic, and breathing sounds revealed diffuse rales and wheezing.
(5) Only miracidia classified as "active" or "slow" were capable of penetration, a capacity they retained for about 17 hours at 19 degrees C. Miracidia that were "lethargic" as a result of low temperature, old age or ultra-violet radiation lost their infective capacity.
(6) The colchicine-treated rats were lethargic and hypothermic as compared to controls.
(7) For the most part, however, this was a night when some familiar old failings could be detected in terms of England looking lethargic in possession.
(8) "People are now lethargic and listless because of starvation.
(9) Considered to be intoxicated from the acute effects of sniffing toluene or methylene chloride, the patient remained lethargic and ataxic despite removal from exposure and administration of supplemental oxygen.
(10) Upon presentation to the ED approximately 2.5 hr post-ingestion, the child was very lethargic and respirations were depressed.
(11) The child remained lethargic for several hours but otherwise had a normal neurological examination.
(12) The Gijon goalkeeper Ivan Cuellar was on fine form, particularly against Ronaldo, while Real’s approach play looked lethargic and too many passes went astray.
(13) A comfortable win was secured early here with Eddie Howe’s team, rightly lauded for their own achievements this season and previously unbeaten away this calendar year, made to look uncharacteristically timid, even lethargic at times, as Spurs swarmed all over them.
(14) Case 1: A 48-year-old woman, who complained of severe headache and vomiting on Feb. 10th, 1972, gradually became lethargic.
(15) Infected dogs were anorectic and lethargic and developed cutaneous lesions characteristic of Rocky Mountain spotted fever, including petechia, ecchymosis, edema, and necrosis.
(16) Lunch had an effect on mood, with subjects feeling more lethargic, feeble, clumsy, muzzy, dreamy, bored and mentally slow after the meal.
(17) Ataxia was not prominent in animals affected with transmissible mink encephalopathy; these animals gradually became more and more lethargic.
(18) On this day, though, the atmosphere became increasingly lethargic as the game wound down and Chelsea went out of the cup.
(19) This was one of their most convincing performances of the season, although it must be said that an uncharacteristically lethargic Everton contributed to their own downfall.
(20) These animals became lethargic, slouched and developed dyspnoea which became progressively more severe during the course of the study.