(a.) Indulging in ease; avoiding labor and exertion; habitually idle; lazy; inactive; as, an indolent man.
(a.) Causing little or no pain or annoyance; as, an indolent tumor.
Example Sentences:
(1) The rate of indole production is increased about 4-fold when the aminoacrylate produced is converted to S-(hydroxyethyl)-L-cysteine by a coupled beta-replacement reaction with beta-mercaptoethanol.
(2) This derivative also allowed sensitive detection and measurement of indole-3-pyruvate in the picogram range using a gas chromatograph with an electron capture detector.
(3) In addition, it has excellent antibacterial activity against indole-positive Proteus strains against which conventional Cephalosporins are ineffective.
(4) These findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes.
(5) Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal.
(6) Among the indoles tested only 6-chloromelatonin, melatonin and N-acetylserotonin had significant affinities to the [125I]iodomelatonin binding site.
(7) Using thin layer chromatography on fluorescent silica gel plates, 5 indoles were identified and 6 unknown substances isolated from the pineal incubate and from both extracts.
(8) It was also found that the levels of s-dTK in the progressive stage were much higher than those in the indolent stage.
(9) Cyclobutadipyrimidines (pyrimidine dimers) undergo splitting that is photosensitized by indole derivatives.
(10) This series of compounds includes [R-(R*,R*)]-4-[[2-[[3-(1H-indol-3-yl)-2-methyl-1-oxo-2- [[(tricyclo[3.3.1.1] dec-2-yloxy)carbonyl]amino]propyl]amino]-1-phenylethyl]amino]- 4-oxobutanoic acid (CI-988, 1, Figure 1), the first rationally designed non-peptide antagonist of a neuropeptide receptor.
(11) Eight of the nine (88.9%) Proteus vulgaris isolates gave a positive spot indole test; one (11.1%) gave a negative result.
(12) 15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and EO9 (3-hydroxymethyl-5-aziridinyl-1-methyl-2-(IH-indole-4,7-dione)prop-beta- en-alpha-ol).
(13) The fluorogenic beta-D-Glucuronidase test, together with an Indol-capillary test for rapid identification of E. coli, were proved with 60 toxinogenic, 335 nontoxinogenic wild-type strains, and 87 other gram-negative isolates from food.
(14) Enzymatic production of L-tryptophan from DL-serine and indole by a coupled reaction of tryptophan synthase and amino acid racemase was studied.
(15) It inhibited some Enterobacter and indole-positive Proteus, but it was less active against these later species than was cefamandole, cefuroxime, or cefoxitin.
(16) An hydroxyl group in the 5 position of the indole nucleus, sterically unencumbered by hydroxyls in neighboing positions, is essential.
(17) We now report a second case with similar features of chronic recurrent indolent inflammatory skin lesions, nondiagnostic skin biopsies, and failure to respond to antibiotics.
(18) In this study, the roots of Tabernaemontana heyneana Wall were examined and the isolation and identification of additional indole alkaloids and some pharmacological properties of coronaridine are described.
(19) In an effort to understand the mechanism by which dietary indoles inhibit chemically initiated tumorigenesis in experimental animals, we have investigated the potency of 3-substituted and 1,3-disubstituted indoles on the induction of intestinal and hepatic cytochrome P-448-dependent monooxygenases in the rat.
(20) Low nanogram levels of tyrosine, norepinephrine, 5-hydroxyindole-3-acetic acid, tryptophan, serotonin and 6-hydroxymelatonin, and picogram levels of 5-hydroxytryptophan, 5-hydroxytryptophol, 5-methoxyindole-3-acetic acid, indole 3-acetic acid, 5-methoxytryptophol and melatonin were indicated in most of the samples.
Slow
Definition:
(v. i.) To go slower; -- often with up; as, the train slowed up before crossing the bridge.
(n.) A moth.
() imp. of Slee, to slay. Slew.
(superl.) Moving a short space in a relatively long time; not swift; not quick in motion; not rapid; moderate; deliberate; as, a slow stream; a slow motion.
(superl.) Not happening in a short time; gradual; late.
(superl.) Not ready; not prompt or quick; dilatory; sluggish; as, slow of speech, and slow of tongue.
(superl.) Not hasty; not precipitate; acting with deliberation; tardy; inactive.
(superl.) Behind in time; indicating a time earlier than the true time; as, the clock or watch is slow.
(superl.) Not advancing or improving rapidly; as, the slow growth of arts and sciences.
(superl.) Heavy in wit; not alert, prompt, or spirited; wearisome; dull.
(adv.) Slowly.
(v. t.) To render slow; to slacken the speed of; to retard; to delay; as, to slow a steamer.
Example Sentences:
(1) Comparison of the S100 alpha-binding protein profiles in fast- and slow-twitch fibers of various species revealed few, if any, species- or fiber type-specific S100 binding proteins.
(2) In dogs, cibenzoline given i.v., had no effects on the slow response systems, probably because of sympathetic nervous system intervention since the class 4 effects of cibenzoline appeared after beta-adrenoceptor blockade.
(3) It is suggested that the rapid phase is due to clearance of peptides in the circulation which results in a fall to lower blood concentrations which are sustained by slow release of peptide from binding sites which act as a depot.
(4) Diphenoxylate-induced hypoxia was the major problem and was associated with slow or fast respirations, hypotonia or rigidity, cardiac arrest, and in 3 cases cerebral edema and death.
(5) The minimal change in gel fiber size caused by slow A release implies that fibrin fiber size is primarily a function of ionic environment and not of the sequence of peptide release.
(6) In electrophysiological studies with neurons of Lymnaea stagnalis, THA inhibited the slow outward K+ current and consequently increased the duration of the action potentials.
(7) It did the job of triggering growth, but it also fueled real-estate speculation, similar to what was going on in the mid-2000s here.” Slowing economic growth may be another concern.
(8) Distant ischemia was distinguished from peri-infarctional ischemia by the presence of transient thallium defects in, or slow thallium washout from myocardium not supplied by the infarct-related coronary artery.
(9) In the absence of haemodialysis, the decline in plasma concentrations of lisinopril and enalaprilat was extremely slow and plasma concentrations were generally high.
(10) Thus serum ionized calcium in untreated essential hypertensive patients may predict the blood pressure response to the slow calcium channel blocker verapamil.
(11) Our results suggest that during simulated ischemia the rate-dependent component of the increase in Ri contributes to the rate-dependence of the conduction slowing.
(12) Recovery after EEDQ administration showed that both receptor production rate and degradation rate constants of anterior pituitary D2 and striatal D1 receptors were slowed after chronic estradiol treatment, whereas recovery rates for striatal D2 dopamine receptors were unaffected.
(13) Variations in light chain composition, particularly fast and slow myosin light chain 1, appeared to occur independently of the variations in heavy chain composition, suggesting that some myosin molecules consist of mixtures of slow- and fast-type subunits.
(14) The toxins preferentially attenuate a slow phase of KCl-evoked glutamate release which may be associated with synaptic vesicle mobilization.
(15) Normal rat soleus myosin has a major slow and a minor fast component due to two populations of muscle fibers.
(16) A calcium dependent potassium conductance was probably involved in the slow phase, because it was sensitive to inorganic calcium blockers.
(17) Although a variety of new teaching strategies and materials are available in education today, medical education has been slow to move away from the traditional lecture format.
(18) The slow alpha-lipoprotein was distributed in the range of densities between low density and high density lipoproteins and was rich in apoprotein E. This abnormal lipoprotein of PBC was observed in those in Stages II and III but not in those in Stage I.
(19) From the third day to the fourth week after this treatment, there was some recovery of the SF rate, and the SCR tended to reappear with a marked slowing down of its habituation.
(20) And that's exciting, you've got no time to slow it down.