(a.) Not to be persuaded or moved by entreaty or prayer; firm; determined; unyielding; unchangeable; inflexible; relentless; as, an inexorable prince or tyrant; an inexorable judge.
Example Sentences:
(1) This condition is a genodermatosis, seen chiefly around the shores of the Mediterranean, characterised by early pigment disturbances which progress virtually inexorably towards a diffuse epitheliomatosis which usually results in death before the age of 20 years.
(2) Or will it slip inexorably into the unchartered waters of default and economic catastrophe?
(3) At this stage, however, the allure of big money Super Pacs has been much stronger on the GOP side, although their ineffectiveness in slowing Trump’s inexorable rise has spawned grousing and finger pointing.
(4) Sceptics think Prokhorov will be one of half a dozen "approved" candidates used to soak up discontent with his soothing talk of inexorable change, while posing no real threat to Putin's supremacy.
(5) It appears that once a dose of asbestos sufficient to initiate the disease has been retained it is inexorably progressive.
(6) This was the logic that initially led the coalition to reject Heathrow expansion, so why is it now, indulged if not quite supported by the opposition, drifting inexorably towards a new runway in the south-east?
(7) And after all the waiting, the killing and the tears, the wheel of history turned inexorably, and all who watched knew it would never turn back.
(8) But imagine that the victim of an industrial accident with a paralyzed hand could achieve new levels of function by inducing axonal regrowth through a synthetic nerve guidance channel; or that a Parkinsonian patient's symptoms could be relieved by implanting in his brain neural tissue encased in a selectively permeable polymer envelope; or that the inexorable progression of the vascular complications of juvenile diabetes could be stopped, even reversed, by a membrane-protected xenograft of insulin-producing tissue.
(9) Throughout the inexorable evolution of the disease, the psychiatrist has to pay attention to the global situation: medical, social and legal.
(10) And some of the more massive trends heading into the future – the inexorables of population growth and global warming, emergent economies and regions with their own claims to truth and justice – would seem largely resistant to the glittering technical fixes that future-types of the past have put their faith in.
(11) And hurt a number of people.” There is a pause, during which one feels Franzen leaning inexorably, and rather endearingly, in a direction that can do him no good.
(12) Even the seemingly inexorable rise of digital media has not emerged unscathed from the downturn.
(13) Was justice itself falling prey to the menacing mood of rightwing fanaticism that has pervaded the country with the inexorable rise of neo-Nazi Golden Dawn?
(14) The left’s weakness has been its belief that there is an inexorable direction to history, that triumph is preordained All of which means that the party’s conference in Brighton in September must be a rigorous campaign launch rather than a carnival of celebration.
(15) It was Tesco's seeming ability to act with impunity that fuelled Simms' determination to write a book exposing how the inexorable rise of supermarkets is bad for everyone - from poorly paid workers in the field, to small, independent shops fast going out of business, to the over-exploited natural environment.
(16) We conclude that bone marrow transplantation can potentially save patients with advanced thalassemia from an otherwise inexorable progression to death from the complications of blood transfusions.
(17) While led by private investment, government often encouraged the process with schemes such as the popular home improvement grants of the 1960s and 70s, hoping to slow what seemed at the time the inexorable decline of the inner cities.
(18) To the dismay of inexperienced politicians in his left-dominated coalition, creditors have dug in their heels with cash reserves drying up inexorably as negotiations over a deal to unlock further bailout funds have gone to the wire.
(19) Nevertheless, perception is key and more and more South Africans view the ANC's glass as half-empty: a jaded organisation tarnished by corruption, delivering too little too slowly and in inexorable decline.
(20) One sees ageing as an inexorable process of decline, and old people as purely a burden, a drain on resources.
Severe
Definition:
(superl.) Serious in feeeling or manner; sedate; grave; austere; not light, lively, or cheerful.
(superl.) Very strict in judgment, discipline, or government; harsh; not mild or indulgent; rigorous; as, severe criticism; severe punishment.
(superl.) Rigidly methodical, or adherent to rule or principle; exactly conformed to a standard; not allowing or employing unneccessary ornament, amplification, etc.; strict; -- said of style, argument, etc.
(superl.) Sharp; afflictive; distressing; violent; extreme; as, severe pain, anguish, fortune; severe cold.
(superl.) Difficult to be endured; exact; critical; rigorous; as, a severe test.
Example Sentences:
(1) We used the polymerase chain reaction (PCR) to amplify the breakpoint area of alpha-thalassemia-1 of Southeast Asia type and several parts of the alpha-globin gene cluster to make a differential diagnosis between alpha-thalassemia-1 and Hb Bart's hydrops fetalis.
(2) The newborn with critical AS typically presents with severe cardiac failure and the infant with moderate failure, whereas children may be asymptomatic.
(3) The low affinity of several N1-alkylpyrroleethylamines suggests that the benzene portion of the alpha-methyltryptamines is necessary for significant affinity.
(4) The main clinical features pertaining to the concept of the "psycho-organic syndrome" (POS) were investigated in a sample of children who suffered from severe craniocerebral trauma.
(5) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(6) Collins said she asked Sullivan several questions, including who the women were.
(7) Single-case experimental designs are presented and discussed from several points of view: Historical antecedents, assessment of the dependent variable, internal and external validity and pre-experimental vs experimental single-case designs.
(8) During and after the infusion of 5HTP, none of the patients showed an increase in anxiety or depressive symptoms, despite the presence of severe side effects.
(9) Histological studies showed that the resulting pancreatitis was usually mild to moderate, being severe only in association with sepsis.
(10) An “out” vote would severely disrupt our lives, in an economic sense and a private sense.
(11) No consistent relationship could be found between the time interval from SAH to operation and the severity of vasospasm.
(12) Also we found that the lipid deposition in the glomeruli of patients with Alagille syndrome is related to an abnormal lipid metabolism, which is the consequence of severe cholestasis.
(13) Sixteen patients in whom schizophrenia was initially diagnosed and who were treated with fluphenazine enanthate or decanoate developed severe depression for a short period after the injection.
(14) Concentrations of several gastrointestinal hormonal peptides were measured in lymph from the cisterna chyli and in arterial plasma; in healthy, conscious pigs during ingestion of a meal.
(15) In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
(16) Based on several previous studies, which demonstrated that sorbitol accumulation in human red blood cells (RBCs) was a function of ambient glucose concentrations, either in vitro or in vivo, our investigations were conducted to determine if RBC sorbitol accumulation would correlate with sorbitol accumulation in lens and nerve tissue of diabetic rats; the effect of sorbinil in reducing sorbitol levels in lens and nerve tissue of diabetic rats would be reflected by changes in RBC sorbitol; and sorbinil would reduce RBC sorbitol in diabetic man.
(17) The severity and site of hypertrophy is important in determining the clinical picture and the natural history of hypertrophic cardiomyopathy (HCM).
(18) After a discussion of the therapeutic relationship, several coping strategies which have been used successfully by many women are described and therapeutic applications are offered.
(19) To clarify the functional roles of His40, Glu58, and His92, we analyzed the consequences of several amino acid substitutions (His40Ala, His40Lys, His40Asp, Glu58Ala, Glu58Gln, and His92Gln) on the kinetics of GpC transesterification.
(20) Moreover, in DCVC-treated cells the mitochondria could not be stained with rhodamine-123, indicating severe mitochondrial damage and loss of membrane potential.