(n.) Blame; cause of blame; fault; crime; offense.
(n.) Deficiency; want; need; destitution; failure; as, a lack of sufficient food.
(v. t.) To blame; to find fault with.
(v. t.) To be without or destitute of; to want; to need.
(v. i.) To be wanting; often, impersonally, with of, meaning, to be less than, short, not quite, etc.
(v. i.) To be in want.
(interj.) Exclamation of regret or surprise.
Example Sentences:
(1) Here we have asked whether protection from blood-borne antigens afforded by the blood-brain barrier is related to the lack of MHC expression.
(2) tRNA from mutant IB13 lacks 5-methylaminomethyl-2-thio-uridine in vivo due to a permanently nonfunctional methyltransferase.
(3) BL6 mouse melanoma cells lack detectable H-2Kb and had low levels of expression of H-2Db Ag.
(4) Treatment termination due to lack of efficacy or combined insufficient therapeutic response and toxicity proved to be influenced by the initial disease activity and by the rank order of prescription.
(5) In the past, the interpretation of the medical findings was hampered by a lack of knowledge of normal anatomy and genital flora in the nonabused prepubertal child.
(6) A diplomatic source said the killing appeared particularly unusual because of Farooq lack of recent political activity: "He was lying low in the past two years.
(7) The present study examined whether the lack of chronic hemodynamic effects of ANP in control rats was due to changes in vascular reactivity to the peptide.
(8) Since it was established, it has stoked controversy about contemporary art, though in recent years it has been more notable for its lack of sensationalism.
(9) Inadequate treatment, caused by a lack of drugs and poorly trained medical attendants, is also a major problem.
(10) Because of the small number of patients reported in the world literature and lack of controlled studies, the treatment of small cell carcinoma of the larynx remains controversial; this retrospective analysis suggests that combination chemotherapy plus radiation offers the best chance for cure.
(11) I would immediately look askance at anyone who lacks the last and possesses the first.
(12) The detection of these antibodies is difficult owing to the lack of standardization and of specificity of the laboratory tests.
(13) Core enzyme, lacking omega subunit, catalyzed this reaction at a rate less than 1% that of holoenzyme.
(14) But not only did it post a larger loss than expected, Amazon also projected 7% to 18% revenue growth over the busiest shopping period of the year, a far cry from the 20%-plus pace that had convinced investors to overlook its persistent lack of profit in the past.
(15) Urine specimens from patient REE also contained a light chain fragment that lacked the first (amino-terminal) 85 residues of the native light chain but otherwise was identical in sequence to the light chain REE.
(16) Thus the failure to raise anti-Id with internal image characteristics may provide an explanation for the lack of anti-gp120 activity reported in anti-Id antisera raised to multiple anti-CD4 antibodies.
(17) His walkout reportedly meant his fellow foreign affairs select committee members could not vote since they lacked a quorum.
(18) In South Africa, health risks associated with exposure to toxic waste sites need to be viewed in the context of current community health concerns, competing causes of disease and ill-health, and the relative lack of knowledge about environmental contamination and associated health effects.
(19) The functional capacity to present antigens to T cells was lacking in normal resting B cells, but was acquired following LK treatment.
(20) These findings indicate an association between HLA-B7 and ankylosing spondylitis in American blacks and suggest that these patients who lack B27 but possess B7 represent a subgroup of patients with this disease.
Loss
Definition:
(v. t.) The act of losing; failure; destruction; privation; as, the loss of property; loss of money by gaming; loss of health or reputation.
(v. t.) The state of losing or having lost; the privation, defect, misfortune, harm, etc., which ensues from losing.
(v. t.) That which is lost or from which one has parted; waste; -- opposed to gain or increase; as, the loss of liquor by leakage was considerable.
(v. t.) The state of being lost or destroyed; especially, the wreck or foundering of a ship or other vessel.
(v. t.) Failure to gain or win; as, loss of a race or battle.
(v. t.) Failure to use advantageously; as, loss of time.
(v. t.) Killed, wounded, and captured persons, or captured property.
(v. t.) Destruction or diminution of value, if brought about in a manner provided for in the insurance contract (as destruction by fire or wreck, damage by water or smoke), or the death or injury of an insured person; also, the sum paid or payable therefor; as, the losses of the company this year amount to a million of dollars.
Example Sentences:
(1) Tryptic digestion of the membranes caused complete disappearance of the binding activity, but heat-treatment for 5 min at 70 degrees C caused only 40% loss of activity.
(2) These studies, in addition to demonstrating that the placenta contains TRH deamidase activity, suggest that losses of fetal TRH through the placenta are not large.
(3) Our results indicate that increasing the delay for more than 8 days following irradiation and TCD syngeneic BMT leads to a rapid loss of the ability to achieve alloengraftment by non-TCD allogeneic bone marrow.
(4) Even with hepatic lipase, phospholipid hydrolysis could not deplete VLDL and IDL of sufficient phospholipid molecules to account for the loss of surface phospholipid that accompanies triacylglycerol hydrolysis and decreasing core volume as LDL is formed (or for conversion of HDL2 to HDL3).
(5) Histological studies of nerves 2 years following irradiation demonstrated loss of axons and myelin, with a corresponding increase in endoneurial, perineurial, and epineurial connective tissue.
(6) The stages of mourning involve cognitive learning of the reality of the loss; behaviours associated with mourning, such as searching, embody unlearning by extinction; finally, physiological concomitants of grief may influence unlearning by direct effects on neurotransmitters or neurohormones, such as cortisol, ACTH, or norepinephrine.
(7) Moreover, in DCVC-treated cells the mitochondria could not be stained with rhodamine-123, indicating severe mitochondrial damage and loss of membrane potential.
(8) Adenosine diphosphate (ADP) afforded significant protection only at the very highest concentration (5.0 mM); inorganic pyrophosphate (PPi) did not protect against loss of latency at any concentration.
(9) The west Africa Ebola epidemic “Few global events match epidemics and pandemics in potential to disrupt human security and inflict loss of life and economic and social damage,” he said.
(10) Thus, it appears that neuronal loss may account for up to roughly half of the striatal D2 receptor loss during aging.
(11) Hearing loss at 8 kHz would shorten the I-V interval, while a loss at 4 kHz would be expected to lengthen the interval.
(12) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(13) With prolonged ischemia, it is only transient and is followed by a gradual loss of the adenylyl cyclase activity.
(14) A murine keratinocyte cell line that is resistant to the growth-inhibitory effects of transforming growth factor beta 1 (TGF beta 1) was examined for differential gene expression patterns that may be related to the mechanism of the loss of TGF beta 1 responsiveness.
(15) Periodontal disease activity is defined clinically by progressive loss of probing attachment and radiographically by progressive loss of alveolar bone.
(16) But not only did it post a larger loss than expected, Amazon also projected 7% to 18% revenue growth over the busiest shopping period of the year, a far cry from the 20%-plus pace that had convinced investors to overlook its persistent lack of profit in the past.
(17) The findings confirm and quantitate the severe atrophy of the neostriatum, in addition to demonstrating a severe loss of cerebral cortex and subcortical white matter in HD.
(18) We could do with similar action to cut out botnets and spam, but there aren't any big-money lobbyists coming to Mandelson pleading loss of business through those.
(19) The triad of epigastric pain unrelieved by antacids, bilious vomiting, and weight loss, particularly after a gastric operation should make one suspect this syndrome.
(20) The temporary loss of a family member through deployment brings unique stresses to a family in three different stages: predeployment, survival, and reunion.